MC2 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

Aug. 6, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

Apo (no ligand) -

PHYSIOLOGICAL LIGANDS

ACTH (Human), ACTH (Mouse)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Polar TM6 K 216 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 216 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 216 6x32 G.H5 L 394 G.H5.26
Hydrophobic ICL2 L 136 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 136 - G.S1 H 41 G.S1.02
Hydrophobic TM3 T 131 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 A 135 - G.H5 Q 384 G.H5.16
Hydrophobic ICL2 R 137 - G.S3 V 217 G.S3.01
Polar TM4 T 143 4x38 G.hns1 R 38 G.hns1.02
Hydrophobic TM5 I 207 5x72 G.h4s6 Y 358 G.h4s6.20
Polar TM3 T 131 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 T 131 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 136 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 136 - G.H5 F 376 G.H5.08
Polar ICL2 H 139 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 H 139 - G.hns1 R 38 G.hns1.02
Hydrophobic TM5 M 196 5x61 G.H5 Y 391 G.H5.23
Hydrophobic TM5 A 200 5x65 G.H5 L 393 G.H5.25
Van-der-waals TM5 A 200 5x65 G.H5 L 393 G.H5.25
Hydrophobic TM5 A 200 5x65 G.H5 L 394 G.H5.26
Van-der-waals TM5 A 200 5x65 G.H5 L 394 G.H5.26
Hydrophobic ICL2 L 136 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 136 - G.H5 I 383 G.H5.15
Ionic TM5 H 203 5x68 G.H5 D 381 G.H5.13
Polar TM5 H 203 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 H 203 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 H 203 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM6 G 217 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 G 217 6x33 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 136 - G.S3 V 217 G.S3.01
Hydrophobic TM5 H 203 5x68 G.H5 L 394 G.H5.26
Polar TM4 T 143 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM4 T 143 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 T 143 4x38 G.HN Q 35 G.HN.52
Aromatic TM3 R 128 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 128 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 128 3x50 G.H5 Y 391 G.H5.23
Polar ICL2 S 140 - G.HN Q 35 G.HN.52
Hydrophobic TM5 L 199 5x64 G.H5 L 388 G.H5.20
Van-der-waals TM5 L 199 5x64 G.H5 L 388 G.H5.20
Hydrophobic H8 P 281 8x48 G.H5 Q 390 G.H5.22
Hydrophobic TM5 I 207 5x72 G.H5 L 394 G.H5.26
Polar TM5 H 203 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 203 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 203 5x68 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 S 140 - G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 S 140 - G.hns1 A 39 G.hns1.03
Hydrophobic TM6 L 221 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM5 L 199 5x64 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 A 135 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 A 135 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 H 139 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 H 139 - G.S1 H 41 G.S1.02
Polar TM3 I 132 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 132 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 132 3x54 G.H5 Q 384 G.H5.16
Ionic TM7 R 279 7x56 G.H5 E 392 G.H5.24
Polar TM7 R 279 7x56 G.H5 E 392 G.H5.24
Hydrophobic TM7 R 279 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 R 279 7x56 G.H5 E 392 G.H5.24
Hydrophobic TM3 I 132 3x54 G.H5 H 387 G.H5.19
Van-der-waals TM3 I 132 3x54 G.H5 H 387 G.H5.19
Polar TM6 K 216 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 216 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM3 I 132 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 132 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM3 I 132 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM5 A 200 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM6 N 214 6x30 G.H5 L 394 G.H5.26
Van-der-waals TM6 N 214 6x30 G.H5 L 394 G.H5.26
Polar TM6 N 214 6x30 G.H5 L 393 G.H5.25
Van-der-waals TM6 N 214 6x30 G.H5 L 393 G.H5.25
Hydrophobic TM5 M 196 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 M 196 5x61 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 136 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 L 136 - G.H5 R 380 G.H5.12
Hydrophobic TM5 H 203 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 H 203 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM6 T 220 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM6 T 220 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 220 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM5 I 207 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 207 5x72 G.H5 R 385 G.H5.17