apelin receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8XQF

RESOLUTION

3.1 Å

REFERENCE

10.1038/S41467-024-55555-6

PUBLICATION DATE

Jan. 22, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

66 interactions (Click to see)

LIGANDS

apelin-13 (Human) - Agonist pubchem gtoplig chembl_ligand uniprot uniprot uniprot

PHYSIOLOGICAL LIGANDS

apelin receptor early endogenous ligand (Mouse), apelin receptor early endogenous ligand (Human), apelin-13 (Human), apelin-17 (Human), Elabela/Toddler-11 (Human), Elabela/Toddler-21 (Human), apelin-36 (Mouse), [Pyr1]apelin-13 (Human), apelin-36 (Human), Elabela/Toddler-32 (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 246 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 246 6x33 G.H5 L 353 G.H5.25
Van-der-waals ICL2 P 134 - G.H5 N 347 G.H5.19
Ionic ICL3 K 234 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 K 234 - G.H5 D 341 G.H5.13
Hydrophobic TM5 F 232 5x69 G.H5 F 354 G.H5.26
Polar TM2 S 63 2x38 G.H5 D 350 G.H5.22
Hydrophobic TM2 S 63 2x38 G.H5 D 350 G.H5.22
Van-der-waals TM2 S 63 2x38 G.H5 D 350 G.H5.22
Hydrophobic TM6 E 238 6x25 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 E 238 6x25 G.h4s6 D 315 G.h4s6.09
Polar TM2 R 62 2x37 G.H5 K 349 G.H5.21
Hydrophobic TM2 R 62 2x37 G.H5 K 349 G.H5.21
Van-der-waals TM2 R 62 2x37 G.H5 K 349 G.H5.21
Polar H8 R 315 8x49 G.H5 K 349 G.H5.21
Hydrophobic H8 R 315 8x49 G.H5 K 349 G.H5.21
Van-der-waals H8 R 315 8x49 G.H5 K 349 G.H5.21
Ionic TM6 R 236 6x23 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 236 6x23 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 R 127 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM5 I 228 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 I 228 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM4 L 142 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 L 142 4x38 G.HN E 28 G.HN.52
Hydrophobic TM3 I 131 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 I 131 3x54 G.H5 N 347 G.H5.19
Hydrophobic ICL2 V 135 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 V 135 - G.S3 L 194 G.S3.01
Hydrophobic TM3 I 131 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 131 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM5 H 231 5x68 G.H5 I 344 G.H5.16
Polar H8 P 314 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 P 314 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 P 314 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM6 I 250 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM5 I 228 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM6 E 238 6x25 G.h4s6 K 314 G.h4s6.08
Van-der-waals TM6 E 238 6x25 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM7 F 312 7x56 G.H5 L 353 G.H5.25
Polar TM3 A 130 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 130 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 130 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 134 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 134 - G.H5 I 343 G.H5.15
Hydrophobic TM7 F 312 7x56 G.H5 F 354 G.H5.26
Van-der-waals TM7 F 312 7x56 G.H5 F 354 G.H5.26
Polar H8 R 315 8x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 131 3x54 G.H5 I 344 G.H5.16
Hydrophobic H8 D 313 8x47 G.H5 F 354 G.H5.26
Van-der-waals H8 D 313 8x47 G.H5 F 354 G.H5.26
Aromatic TM6 R 245 6x32 G.H5 F 354 G.H5.26
Ionic TM5 H 231 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 H 231 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 H 231 5x68 G.H5 D 341 G.H5.13
Aromatic TM5 F 232 5x69 G.H5 K 345 G.H5.17
Hydrophobic TM5 F 232 5x69 G.H5 K 345 G.H5.17
Van-der-waals TM5 F 232 5x69 G.H5 K 345 G.H5.17
Hydrophobic TM6 I 249 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM2 A 64 2x39 G.H5 C 351 G.H5.23
Ionic TM2 R 62 2x37 G.H5 D 350 G.H5.22
Polar TM2 R 62 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 R 62 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 R 62 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM4 L 142 4x38 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 L 142 4x38 G.hns1 R 32 G.hns1.03
Hydrophobic H8 R 315 8x49 G.H5 F 354 G.H5.26
Hydrophobic TM7 F 312 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 F 312 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM6 L 246 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 L 246 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 134 - G.H5 I 344 G.H5.16
Hydrophobic TM5 F 232 5x69 G.H5 L 348 G.H5.20
Hydrophobic H8 D 313 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 D 313 8x47 G.H5 G 352 G.H5.24
Polar TM5 H 231 5x68 G.H5 K 345 G.H5.17
Van-der-waals TM5 H 231 5x68 G.H5 K 345 G.H5.17
Polar TM3 R 127 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 127 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 127 3x50 G.H5 C 351 G.H5.23