Ligand
Function
Agonist
Reference
| Ligand | Amino Acid | Generic Number | Segment | Interaction Type |
|---|---|---|---|---|
| apelin-13 (Human) | W85 | 2.60x60 | TM2 | hydrophobic |
| apelin-13 (Human) | Y88 | 2.63x63 | TM2 | Van der Waals |
| apelin-13 (Human) | Y88 | 2.63x63 | TM2 | polar (hydrogen bond) |
| apelin-13 (Human) | Y93 | ECL1 | hydrophobic | |
| apelin-13 (Human) | Y93 | ECL1 | Van der Waals | |
| apelin-13 (Human) | F110 | 3.33x33 | TM3 | Van der Waals |
| apelin-13 (Human) | F110 | 3.33x33 | TM3 | hydrophobic |
| apelin-13 (Human) | V164 | 4.60x61 | TM4 | hydrophobic |
| apelin-13 (Human) | V164 | 4.60x61 | TM4 | Van der Waals |
| apelin-13 (Human) | E174 | ECL2 | polar (charge-assisted hydrogen bond) | |
| apelin-13 (Human) | Q180 | ECL2 | polar (hydrogen bond) | |
| apelin-13 (Human) | Y182 | 45.51x51 | ECL2 | Van der Waals |
| apelin-13 (Human) | M183 | 45.52x52 | ECL2 | polar (hydrogen bond with backbone) |
| apelin-13 (Human) | M183 | 45.52x52 | ECL2 | Van der Waals |
| apelin-13 (Human) | Y185 | ECL2 | Van der Waals | |
| apelin-13 (Human) | E194 | 5.31x32 | TM5 | polar (charge-assisted hydrogen bond) |
| apelin-13 (Human) | E198 | 5.35x36 | TM5 | polar (charge-assisted hydrogen bond) |
| apelin-13 (Human) | L201 | 5.38x39 | TM5 | hydrophobic |
| apelin-13 (Human) | L201 | 5.38x39 | TM5 | Van der Waals |
| apelin-13 (Human) | G202 | 5.39x40 | TM5 | Van der Waals |
| apelin-13 (Human) | S205 | 5.42x43 | TM5 | Van der Waals |
| apelin-13 (Human) | Y264 | 6.51x51 | TM6 | polar (hydrogen bond) |
| apelin-13 (Human) | Y264 | 6.51x51 | TM6 | Van der Waals |
| apelin-13 (Human) | K268 | 6.55x55 | TM6 | polar (charge-assisted hydrogen bond) |
| apelin-13 (Human) | Y271 | 6.58x58 | TM6 | polar (hydrogen bond) |
| apelin-13 (Human) | Y271 | 6.58x58 | TM6 | polar (hydrogen bond) |
| apelin-13 (Human) | S275 | 6.62x62 | TM6 | Van der Waals |
| apelin-13 (Human) | F291 | 7.35x34 | TM7 | hydrophobic |
| apelin-13 (Human) | Y299 | 7.43x42 | TM7 | Van der Waals |
| apelin-13 (Human) | Y299 | 7.43x42 | TM7 | hydrophobic |
, 'snake_8XQF.png', {scale: 3});){kind=link}
, 'helixbox8XQF.png', {scale: 3});){kind=link}
|
GPCRdb(A)
|
GPCRdb(A)
|
apelin receptor
|
|---|---|---|
| TM2 | ||
| 2x60 | 2.60x60 | W85 |
| 2x63 | 2.63x63 | Y88 |
| TM3 | ||
| 3x33 | 3.33x33 | F110 |
| TM4 | ||
| 4x61 | 4.60x61 | V164 |
| ECL2 | ||
| 45x51 | 45.51x51 | Y182 |
| 45x52 | 45.52x52 | M183 |
| TM5 | ||
| 5x32 | 5.31x32 | E194 |
| 5x36 | 5.35x36 | E198 |
| 5x39 | 5.38x39 | L201 |
| 5x40 | 5.39x40 | G202 |
| 5x43 | 5.42x43 | S205 |
| TM6 | ||
| 6x51 | 6.51x51 | Y264 |
| 6x55 | 6.55x55 | K268 |
| 6x58 | 6.58x58 | Y271 |
| 6x62 | 6.62x62 | S275 |
| TM7 | ||
| 7x34 | 7.35x34 | F291 |
| 7x42 | 7.43x42 | Y299 |