GPR156 (gp156_human)
FAMILY
Class C (Glutamate) Orphan receptors Class C Orphans GPR156
GENE
GPR156 (GABABL, PGR28)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Probable G-protein coupled receptor 156, G-protein coupled receptor PGR28, GABAB-related G-protein coupled receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
E
|
P
|
E
|
I
|
N
|
C
|
S
|
E
|
L
|
10 |
C
|
D
|
S
|
F
|
P
|
G
|
Q
|
E
|
L
|
D
|
20 |
R
|
R
|
P
|
L
|
H
|
D
|
L
|
C
|
K
|
T
|
30 |
T
|
I
|
T
|
S
|
S
|
H
|
H
|
S
|
S
|
K
|
40 |
TM1 | |||||||||
T
|
I
|
S
|
S
|
L
|
S
|
P
|
V
|
L
|
L
|
50 |
G
|
I
|
V
|
W
|
T
|
F
|
L
|
S
|
C
|
G
|
60 |
L
|
L
|
L
|
I
|
L
|
F
|
F
|
L
|
A
|
F
|
70 |
ICL1 | |||||||||
T
|
I
|
H
|
C
|
R
|
K
|
N
|
R
|
I
|
V
|
80 |
TM2 | |||||||||
K
|
M
|
S
|
S
|
P
|
N
|
L
|
N
|
I
|
V
|
90 |
T
|
L
|
L
|
G
|
S
|
C
|
L
|
T
|
Y
|
S
|
100 |
S
|
A
|
Y
|
L
|
F
|
G
|
I
|
Q
|
D
|
V
|
110 |
ECL1 | TM3 | ||||||||
L
|
V
|
G
|
S
|
S
|
M
|
E
|
T
|
L
|
I
|
120 |
Q
|
T
|
R
|
L
|
S
|
M
|
L
|
C
|
I
|
G
|
130 |
T
|
S
|
L
|
V
|
F
|
G
|
P
|
I
|
L
|
G
|
140 |
K
|
S
|
W
|
R
|
L
|
Y
|
K
|
V
|
F
|
T
|
150 |
ICL2 | |||||||||
Q
|
R
|
V
|
P
|
D
|
K
|
R
|
V
|
I
|
I
|
160 |
TM4 | |||||||||
K
|
D
|
L
|
Q
|
L
|
L
|
G
|
L
|
V
|
A
|
170 |
A
|
L
|
L
|
M
|
A
|
D
|
V
|
I
|
L
|
L
|
180 |
M
|
T
|
W
|
V
|
L
|
T
|
D
|
P
|
I
|
Q
|
190 |
ECL2 | |||||||||
C
|
L
|
Q
|
I
|
L
|
S
|
V
|
S
|
M
|
T
|
200 |
V
|
T
|
G
|
K
|
D
|
V
|
S
|
C
|
T
|
S
|
210 |
T
|
S
|
T
|
H
|
F
|
C
|
A
|
S
|
R
|
Y
|
220 |
TM5 | |||||||||
S
|
D
|
V
|
W
|
I
|
A
|
L
|
I
|
W
|
G
|
230 |
C
|
K
|
G
|
L
|
L
|
L
|
L
|
Y
|
G
|
A
|
240 |
Y
|
L
|
A
|
G
|
L
|
T
|
G
|
H
|
V
|
S
|
250 |
ICL3 | TM6 | ||||||||
S
|
P
|
P
|
V
|
N
|
Q
|
S
|
L
|
T
|
I
|
260 |
M
|
V
|
G
|
V
|
N
|
L
|
L
|
V
|
L
|
A
|
270 |
A
|
G
|
L
|
L
|
F
|
V
|
V
|
T
|
R
|
Y
|
280 |
ECL3 | TM7 | ||||||||
L
|
H
|
S
|
W
|
P
|
N
|
L
|
V
|
F
|
G
|
290 |
L
|
T
|
S
|
G
|
G
|
I
|
F
|
V
|
C
|
T
|
300 |
T
|
T
|
I
|
N
|
C
|
F
|
I
|
F
|
I
|
P
|
310 |
H8 | |||||||||
Q
|
L
|
K
|
Q
|
W
|
K
|
A
|
F
|
E
|
E
|
320 |
E
|
N
|
Q
|
T
|
I
|
R
|
R
|
M
|
A
|
K
|
330 |
C-term | |||||||||
Y
|
F
|
S
|
T
|
P
|
N
|
K
|
S
|
F
|
H
|
340 |
T
|
Q
|
Y
|
G
|
E
|
E
|
E
|
N
|
C
|
H
|
350 |
P
|
R
|
G
|
E
|
K
|
S
|
S
|
M
|
E
|
R
|
360 |
L
|
L
|
T
|
E
|
K
|
N
|
A
|
V
|
I
|
E
|
370 |
S
|
L
|
Q
|
E
|
Q
|
V
|
N
|
N
|
A
|
K
|
380 |
E
|
K
|
I
|
V
|
R
|
L
|
M
|
S
|
A
|
E
|
390 |
C
|
T
|
Y
|
D
|
L
|
P
|
E
|
G
|
A
|
A
|
400 |
P
|
P
|
A
|
S
|
S
|
P
|
N
|
K
|
D
|
V
|
410 |
Q
|
A
|
V
|
A
|
S
|
V
|
H
|
T
|
L
|
A
|
420 |
A
|
A
|
Q
|
G
|
P
|
S
|
G
|
H
|
L
|
S
|
430 |
D
|
F
|
Q
|
N
|
D
|
P
|
G
|
M
|
A
|
A
|
440 |
R
|
D
|
S
|
Q
|
C
|
T
|
S
|
G
|
P
|
S
|
450 |
S
|
Y
|
A
|
Q
|
S
|
L
|
E
|
G
|
P
|
G
|
460 |
K
|
D
|
S
|
S
|
F
|
S
|
P
|
G
|
K
|
E
|
470 |
E
|
K
|
I
|
S
|
D
|
S
|
K
|
D
|
F
|
S
|
480 |
D
|
H
|
L
|
D
|
S
|
G
|
C
|
S
|
Q
|
K
|
490 |
P
|
W
|
T
|
E
|
Q
|
S
|
L
|
G
|
P
|
E
|
500 |
R
|
G
|
D
|
Q
|
V
|
P
|
M
|
N
|
P
|
S
|
510 |
Q
|
S
|
L
|
L
|
P
|
E
|
R
|
G
|
G
|
S
|
520 |
D
|
P
|
Q
|
R
|
Q
|
R
|
H
|
L
|
E
|
N
|
530 |
S
|
E
|
E
|
P
|
P
|
E
|
R
|
R
|
S
|
R
|
540 |
V
|
S
|
S
|
V
|
I
|
R
|
E
|
K
|
L
|
Q
|
550 |
E
|
V
|
L
|
Q
|
D
|
L
|
G
|
L
|
G
|
P
|
560 |
E
|
A
|
S
|
L
|
S
|
T
|
A
|
P
|
S
|
C
|
570 |
H
|
Q
|
Q
|
T
|
W
|
K
|
N
|
S
|
A
|
A
|
580 |
F
|
S
|
P
|
Q
|
K
|
M
|
P
|
L
|
S
|
K
|
590 |
E
|
L
|
G
|
F
|
S
|
P
|
Y
|
M
|
V
|
R
|
600 |
R
|
R
|
R
|
A
|
A
|
Q
|
R
|
A
|
R
|
S
|
610 |
H
|
F
|
P
|
G
|
S
|
A
|
P
|
S
|
S
|
V
|
620 |
G
|
H
|
R
|
A
|
N
|
R
|
T
|
V
|
P
|
G
|
630 |
A
|
H
|
S
|
R
|
L
|
H
|
V
|
Q
|
N
|
G
|
640 |
D
|
S
|
P
|
S
|
L
|
A
|
P
|
Q
|
T
|
T
|
650 |
D
|
S
|
R
|
V
|
R
|
R
|
P
|
S
|
S
|
R
|
660 |
K
|
P
|
S
|
L
|
P
|
S
|
D
|
P
|
Q
|
D
|
670 |
R
|
P
|
G
|
T
|
L
|
E
|
G
|
S
|
K
|
Q
|
680 |
S
|
Q
|
T
|
E
|
P
|
E
|
G
|
A
|
R
|
G
|
690 |
S
|
K
|
A
|
A
|
F
|
L
|
R
|
Q
|
P
|
S
|
700 |
G
|
S
|
G
|
R
|
A
|
P
|
S
|
P
|
A
|
A
|
710 |
P
|
C
|
L
|
S
|
K
|
A
|
S
|
P
|
D
|
L
|
720 |
P
|
E
|
Q
|
W
|
Q
|
L
|
W
|
P
|
P
|
V
|
730 |
P
|
S
|
G
|
C
|
A
|
S
|
L
|
S
|
S
|
Q
|
740 |
H
|
S
|
Y
|
F
|
D
|
T
|
E
|
S
|
S
|
S
|
750 |
S
|
D
|
E
|
F
|
F
|
C
|
R
|
C
|
H
|
R
|
760 |
P
|
Y
|
C
|
E
|
I
|
C
|
F
|
Q
|
S
|
S
|
770 |
S
|
D
|
S
|
S
|
D
|
S
|
G
|
T
|
S
|
D
|
780 |
T
|
D
|
P
|
E
|
P
|
T
|
G
|
G
|
L
|
A
|
790 |
S
|
W
|
E
|
K
|
L
|
W
|
A
|
R
|
S
|
K
|
800 |
P
|
I
|
V
|
N
|
F
|
K
|
D
|
D
|
L
|
K
|
810 |
P
|
T
|
L
|
V
|
LINKS
DIAGRAMS
7TM
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
No physiological ligands available