XCR1 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.1 Å

REFERENCE

PUBLICATION DATE

Dec. 11, 2024

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

Lymphotactin - Agonist

PHYSIOLOGICAL LIGANDS

XCL2, XCL1



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Polar TM3 S 130 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 S 130 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 S 130 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 Y 205 5x58 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 135 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 L 138 34x54 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 138 34x54 G.S3 L 194 G.S3.01
Hydrophobic ICL2 L 138 34x54 G.H5 I 343 G.H5.15
Hydrophobic ICL2 P 134 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 134 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM6 I 227 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 134 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 134 34x50 G.H5 I 343 G.H5.15
Ionic TM4 R 146 4x42 G.HN E 28 G.HN.52
Polar TM4 R 146 4x42 G.HN E 28 G.HN.52
Van-der-waals TM4 R 146 4x42 G.HN E 28 G.HN.52
Hydrophobic H8 V 292 8x48 G.H5 K 349 G.H5.21
Van-der-waals H8 V 292 8x48 G.H5 K 349 G.H5.21
Polar TM3 R 127 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 127 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 T 223 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM3 V 131 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 131 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM2 T 66 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM6 L 226 6x36 G.H5 F 354 G.H5.26
Polar H8 G 291 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 G 291 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM5 L 212 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM6 L 226 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 135 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 V 140 34x56 G.HN E 28 G.HN.52
Polar TM6 T 223 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 223 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 223 6x33 G.H5 L 353 G.H5.25
Polar ICL3 S 217 - G.H5 K 345 G.H5.17
Hydrophobic ICL3 S 217 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 S 217 - G.H5 K 345 G.H5.17
Hydrophobic ICL3 R 219 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 R 219 - G.H5 F 354 G.H5.26
Hydrophobic TM5 L 212 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 134 34x50 G.H5 T 340 G.H5.12
Polar TM6 R 222 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 222 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 222 6x32 G.H5 F 354 G.H5.26