Refined structure (8HBD) of Gi1 - ETB receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR

Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 215 from structure (60.7%), 139 from model (39.3%)
Residue sidechains - 205 from structure (57.9%), 149 from model (42.1%)

REFINED GPCR RESIDUES

Residue backbones - 294 from structure (71.2%), 119 from model (28.8%)
Residue sidechains - 270 from structure (65.4%), 143 from model (34.6%)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
K34A35E38E52G.HNE12G.h4s6Y02G.S6D13D22C23G24G.H5GproteinQ6x29G-R3x50I34x56H6x26P-N12x52S8x47F-GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.HNG.h4s6G.S6G.H5GPCR segments:N-termICL1ICL2TM3TM6H8

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
Res. Pos.

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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