FFA4 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

24QH

RESOLUTION

2.7 Å

REFERENCE

PUBLICATION DATE

July 8, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) -

PHYSIOLOGICAL LIGANDS

linoleic acid, myristic acid, oleic acid, α-linolenic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic C-term L 325 - G.H5 G 352 G.H5.24
Hydrophobic ICL2 L 143 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 143 - G.H5 I 343 G.H5.15
Hydrophobic TM5 I 230 5x61 G.H5 L 348 G.H5.20
Polar TM3 R 136 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 136 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM5 S 244 5x75 G.H5 F 334 G.H5.06
Hydrophobic ICL2 P 150 - G.HN R 24 G.HN.48
Van-der-waals ICL2 P 150 - G.HN R 24 G.HN.48
Hydrophobic C-term T 324 - G.H5 F 354 G.H5.26
Hydrophobic TM6 T 265 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM5 I 230 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM5 R 238 5x69 G.H5 K 345 G.H5.17
Van-der-waals TM5 R 238 5x69 G.H5 K 345 G.H5.17
Hydrophobic ICL2 L 143 - G.H5 I 344 G.H5.16
Hydrophobic ICL2 R 145 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 145 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 R 148 - G.hns1 A 31 G.hns1.02
Hydrophobic TM5 L 241 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 L 241 5x72 G.S6 Y 320 G.S6.02
Hydrophobic TM3 I 140 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM5 S 237 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 S 237 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM6 L 262 6x34 G.H5 F 354 G.H5.26
Hydrophobic TM6 L 262 6x34 G.H5 L 348 G.H5.20
Hydrophobic TM5 L 241 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 L 241 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM3 I 140 3x54 G.H5 L 348 G.H5.20
Polar TM5 R 240 5x71 G.H5 T 340 G.H5.12
Ionic TM5 R 240 5x71 G.H5 D 337 G.H5.09
Polar TM3 C 139 3x53 G.H5 N 347 G.H5.19
Ionic TM5 R 238 5x69 G.H5 D 341 G.H5.13
Polar TM5 R 238 5x69 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 238 5x69 G.H5 D 341 G.H5.13
Hydrophobic TM5 L 241 5x72 G.H5 A 338 G.H5.10
Hydrophobic TM3 C 139 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 150 - G.HN E 28 G.HN.52
Van-der-waals ICL2 P 150 - G.HN E 28 G.HN.52
Van-der-waals TM6 L 262 6x34 G.H5 L 353 G.H5.25
Hydrophobic C-term T 324 - G.H5 L 353 G.H5.25
Hydrophobic TM6 L 266 6x38 G.H5 L 353 G.H5.25
Hydrophobic ICL2 Q 144 - G.S1 V 34 G.S1.02
Van-der-waals ICL2 Q 144 - G.S1 V 34 G.S1.02
Polar ICL2 Q 144 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 Q 144 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 Q 144 - G.hns1 A 31 G.hns1.02
Ionic ICL2 R 145 - G.HN E 28 G.HN.52
Polar ICL2 R 145 - G.HN E 28 G.HN.52
Ionic ICL2 R 152 - G.HN E 28 G.HN.52
Polar ICL2 R 152 - G.HN E 28 G.HN.52
Hydrophobic ICL2 R 152 - G.HN E 28 G.HN.52
Van-der-waals ICL2 R 152 - G.HN E 28 G.HN.52
Hydrophobic ICL2 Q 144 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 144 - G.hns1 R 32 G.hns1.03
Ionic ICL2 R 148 - G.HN E 28 G.HN.52
Polar ICL2 R 148 - G.HN E 28 G.HN.52
Hydrophobic ICL2 R 148 - G.HN E 28 G.HN.52
Polar TM6 H 251 6x23 G.S6 I 319 G.S6.01
Hydrophobic TM5 I 233 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 I 233 5x64 G.H5 I 344 G.H5.16
Hydrophobic ICL3 A 246 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 A 246 - G.H5 F 334 G.H5.06
Hydrophobic TM5 L 241 5x72 G.H5 D 337 G.H5.09
Polar TM6 Q 258 6x30 G.H5 K 345 G.H5.17
Hydrophobic TM6 R 254 6x26 G.h4s6 K 314 G.h4s6.08
Polar TM6 S 248 6x20 G.H4 E 308 G.H4.16
Hydrophobic TM6 S 248 6x20 G.H4 E 308 G.H4.16
Van-der-waals TM6 S 248 6x20 G.H4 E 308 G.H4.16
Hydrophobic TM3 R 136 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 136 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 269 6x41 G.H5 L 353 G.H5.25
Polar ICL2 Q 144 - G.S1 E 33 G.S1.01
Hydrophobic ICL2 Q 144 - G.S1 E 33 G.S1.01
Van-der-waals ICL2 Q 144 - G.S1 E 33 G.S1.01
Ionic TM6 H 251 6x23 G.h4s6 E 318 G.h4s6.12
Polar TM6 H 251 6x23 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 H 251 6x23 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 H 251 6x23 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 Q 144 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 Q 144 - G.H5 I 343 G.H5.15