ghrelin receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9V2N

RESOLUTION

2.6 Å

REFERENCE

PUBLICATION DATE

July 2, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

47 interactions (Click to see)

LIGANDS

macimorelin - Agonist pubchem gtoplig chembl_ligand drugbank pubchem

PHYSIOLOGICAL LIGANDS

[des-Gln14]ghrelin (Mouse), liver enriched antimicrobial peptide 2 (Human), ghrelin (Mouse), [des-Gln14]ghrelin (Human), ghrelin (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 H 258 6x30 G.H5 Q 385 G.H5.17
Van-der-waals TM6 H 258 6x30 G.H5 Q 385 G.H5.17
Polar H8 S 327 8x47 G.H5 N 392 G.H5.24
Hydrophobic H8 S 327 8x47 G.H5 N 392 G.H5.24
Van-der-waals H8 S 327 8x47 G.H5 N 392 G.H5.24
Hydrophobic ICL2 L 149 - G.H5 K 380 G.H5.12
Van-der-waals ICL2 L 149 - G.H5 K 380 G.H5.12
Hydrophobic H8 S 327 8x47 G.H5 V 394 G.H5.26
Van-der-waals H8 S 327 8x47 G.H5 V 394 G.H5.26
Hydrophobic TM2 L 82 2x43 G.H5 N 392 G.H5.24
Van-der-waals TM2 L 82 2x43 G.H5 N 392 G.H5.24
Ionic H8 K 329 8x49 G.H5 E 390 G.H5.22
Polar H8 K 329 8x49 G.H5 E 390 G.H5.22
Van-der-waals H8 K 329 8x49 G.H5 E 390 G.H5.22
Hydrophobic TM2 T 78 2x39 G.H5 N 392 G.H5.24
Polar TM3 R 141 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 141 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 141 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM7 M 326 7x56 G.H5 L 393 G.H5.25
Van-der-waals TM7 M 326 7x56 G.H5 L 393 G.H5.25
Hydrophobic TM6 H 258 6x30 G.H5 L 388 G.H5.20
Hydrophobic TM3 I 145 3x54 G.H5 N 387 G.H5.19
Hydrophobic TM5 L 239 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM3 E 140 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 140 3x49 G.H5 Y 391 G.H5.23
Polar H8 K 328 8x48 G.H5 V 394 G.H5.26
Hydrophobic TM3 A 144 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 144 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 239 5x65 G.H5 L 384 G.H5.16
Hydrophobic TM3 I 145 3x54 G.H5 L 393 G.H5.25
Van-der-waals TM3 I 145 3x54 G.H5 L 393 G.H5.25
Polar TM3 R 141 3x50 G.H5 N 392 G.H5.24
Hydrophobic TM3 R 141 3x50 G.H5 L 393 G.H5.25
Polar TM3 A 144 3x53 G.H5 N 387 G.H5.19
Hydrophobic TM3 A 144 3x53 G.H5 N 387 G.H5.19
Van-der-waals TM3 A 144 3x53 G.H5 N 387 G.H5.19
Hydrophobic ICL2 L 149 - G.H5 C 379 G.H5.11
Hydrophobic TM2 T 78 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 T 78 2x39 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 149 - G.S3 V 217 G.S3.01
Polar TM6 T 261 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 T 261 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 261 6x33 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 148 - G.H5 L 384 G.H5.16
Polar ICL2 P 148 - G.H5 N 387 G.H5.19
Hydrophobic ICL2 L 149 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 149 - G.H5 I 383 G.H5.15
Hydrophobic TM7 M 326 7x56 G.H5 V 394 G.H5.26
Van-der-waals TM7 M 326 7x56 G.H5 V 394 G.H5.26
Van-der-waals ICL2 A 151 - G.hns1 R 39 G.hns1.03
Hydrophobic ICL2 P 148 - G.H5 I 383 G.H5.15
Hydrophobic TM5 K 238 5x64 G.H5 L 384 G.H5.16
Van-der-waals TM5 K 238 5x64 G.H5 L 384 G.H5.16
Hydrophobic TM7 M 326 7x56 G.H5 N 392 G.H5.24
Van-der-waals TM7 M 326 7x56 G.H5 N 392 G.H5.24
Hydrophobic TM6 L 265 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 265 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 145 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 145 3x54 G.H5 L 388 G.H5.20
Polar TM2 T 78 2x39 G.H5 E 390 G.H5.22
Hydrophobic ICL2 L 149 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 149 - G.H5 F 376 G.H5.08
Polar H8 S 327 8x47 G.H5 R 389 G.H5.21
Hydrophobic TM3 I 145 3x54 G.H5 L 384 G.H5.16
Van-der-waals TM3 I 145 3x54 G.H5 L 384 G.H5.16
Polar TM7 Y 323 7x53 G.H5 N 392 G.H5.24
Hydrophobic TM7 Y 323 7x53 G.H5 N 392 G.H5.24
Van-der-waals TM7 Y 323 7x53 G.H5 N 392 G.H5.24
Hydrophobic ICL2 L 149 - G.S1 L 41 G.S1.02
Hydrophobic TM6 T 261 6x33 G.H5 V 394 G.H5.26
Van-der-waals TM6 T 261 6x33 G.H5 V 394 G.H5.26