PDB
9V2N
Resolution
2.6 Å
Released
July 2, 2025
Receptor
ghrelin
Class
A
Species
Homo sapiens
Ligand
macimorelin
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
macimorelin D99 2.60x60 TM2 polar (charge-assisted hydrogen bond)
macimorelin R102 2.63x63 TM2 polar (charge-assisted hydrogen bond)
macimorelin Q120 3.29x29 TM3 Van der Waals
macimorelin Q120 3.29x29 TM3 polar (hydrogen bond)
macimorelin S123 3.32x32 TM3 polar (hydrogen bond)
macimorelin E124 3.33x33 TM3 Van der Waals
macimorelin I178 4.60x61 TM4 Van der Waals
macimorelin R199 45.51x51 ECL2 Van der Waals
macimorelin L210 5.36x36 TM5 hydrophobic
macimorelin L210 5.36x36 TM5 Van der Waals
macimorelin M213 5.39x39 TM5 hydrophobic
macimorelin V214 5.40x40 TM5 hydrophobic
macimorelin V214 5.40x40 TM5 Van der Waals
macimorelin F279 6.51x51 TM6 Van der Waals
macimorelin F279 6.51x51 TM6 hydrophobic
macimorelin R283 6.55x55 TM6 polar (charge-assisted hydrogen bond)
macimorelin F286 6.58x58 TM6 Van der Waals
macimorelin F286 6.58x58 TM6 hydrophobic
macimorelin N305 7.35x34 TM7 Van der Waals
macimorelin S308 7.38x37 TM7 Van der Waals
macimorelin F309 7.39x38 TM7 hydrophobic
macimorelin F309 7.39x38 TM7 Van der Waals
macimorelin F312 7.42x41 TM7 aromatic (face-to-edge)
macimorelin F312 7.42x41 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R E L R ICL1ECL1 R P W N F ECL1ICL2 P L R A K V V V ICL2ECL2 G V E H E N G T D P W D T N E C R P T E F A V R S ECL2ICL3 A V V G A ICL3ECL3 P G S ECL3N-term M W N A T P S E E P G F N L T L A D L D W D A S P G N D S L G D E L L Q L F N-termC-term F S Q R K L S T L K D E S S R A W T E S S I N T C-term P A P L L A G V T A T C V A L F V V G I A G N L L T M L V V S R F T T T N L Y L S S M A F S D L L I F L C M P L D L V R L W Q Y G D L L C K L F Q F V S E S C T Y A T V L T I T A L S V E R Y F A I C F T K G R V K L V I F V I W A V A F C S A G P I F V L V G L L T V M V W V S S I F F F L P V F C L T V L Y S L I G R K L W R R R R G D S L R D Q N H K Q T V K M L A V V V F A F I L C W L P F H V G R Y L F S K S F E L E I A Q I S Q Y C N L V S F V L F Y L S A A I N P I L Y N I M S K K V F R E P Y R V A L L G F
Helix box plot — Download: PNG | SVG L N G A I G V V F L A V C T A T V G A L 1 S S M A F S D L L I F L C M P L D L V R 2 A T I T L V T A Y T C S E S V F Q F L K 3 V K L V I F V I W A V A F C S A G P I 4 Y L V T L C F V P L F F F I S S V W V M 5 A V V V F A F I L C W L P F H V G R Y L 6 I P N I A A S L Y F L V F S V L N C Y 7

GPCRdb(A)
GPCRdb(A)
ghrelin receptor
TM2
2x60 2.60x60 D99
2x63 2.63x63 R102
TM3
3x29 3.29x29 Q120
3x32 3.32x32 S123
3x33 3.33x33 E124
TM4
4x61 4.60x61 I178
ECL2
45x51 45.51x51 R199
TM5
5x36 5.36x36 L210
5x39 5.39x39 M213
5x40 5.40x40 V214
TM6
6x51 6.51x51 F279
6x55 6.55x55 R283
6x58 6.58x58 F286
TM7
7x34 7.35x34 N305
7x37 7.38x37 S308
7x38 7.39x38 F309
7x41 7.42x41 F312