OX2 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7SR8

RESOLUTION

3.3 Å

REFERENCE

10.1038/S41467-022-30601-3

PUBLICATION DATE

June 8, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

36 interactions (Click to see)

LIGANDS

methyl (2R,3S)-3-[(methanesulfonyl)amino]-2-({[(1s,4S)-4-phenylcyclohexyl]oxy}methyl)piperidine-1-carboxylate - Agonist pubchem

PHYSIOLOGICAL LIGANDS

orexin-B, orexin-A



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 Q 295 6x26 G.H5 Q 229 G.H5.17
Van-der-waals TM6 Q 295 6x26 G.H5 Q 229 G.H5.17
Polar ICL2 F 162 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 F 162 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 F 162 - G.hns1 R 32 G.hns1.03
Polar TM6 R 299 6x30 G.H5 Q 229 G.H5.17
Van-der-waals TM6 R 299 6x30 G.H5 Q 229 G.H5.17
Hydrophobic TM3 R 152 3x50 G.H5 Y 235 G.H5.23
Hydrophobic H8 K 370 8x49 G.H5 R 233 G.H5.21
Van-der-waals H8 K 370 8x49 G.H5 R 233 G.H5.21
Polar H8 F 371 8x50 G.H5 N 236 G.H5.24
Hydrophobic H8 F 371 8x50 G.H5 N 236 G.H5.24
Van-der-waals H8 F 371 8x50 G.H5 N 236 G.H5.24
Hydrophobic TM2 T 89 2x39 G.H5 Y 235 G.H5.23
Van-der-waals TM2 T 89 2x39 G.H5 Y 235 G.H5.23
Polar H8 S 368 8x47 G.H5 N 236 G.H5.24
Hydrophobic H8 S 368 8x47 G.H5 N 236 G.H5.24
Van-der-waals H8 S 368 8x47 G.H5 N 236 G.H5.24
Hydrophobic H8 K 370 8x49 G.H5 N 236 G.H5.24
Polar H8 G 369 8x48 G.s4h3 V 238 G.s4h3.07
Polar TM2 T 89 2x39 G.s4h3 E 234 G.s4h3.03
Hydrophobic ICL2 F 162 - G.S1 L 34 G.S1.02
Hydrophobic TM3 R 152 3x50 G.H5 L 237 G.H5.25
Hydrophobic TM3 I 156 3x54 G.H5 L 228 G.H5.16
Van-der-waals TM3 I 156 3x54 G.H5 L 228 G.H5.16
Hydrophobic ICL2 F 162 - G.H5 I 227 G.H5.15
Polar ICL2 S 164 - G.H5 Y 235 G.H5.23
Van-der-waals ICL2 S 164 - G.H5 Y 235 G.H5.23
Hydrophobic TM6 R 299 6x30 G.H5 L 228 G.H5.16
Hydrophobic ICL2 L 160 - G.S1 L 34 G.S1.02
Van-der-waals ICL2 L 160 - G.S1 L 34 G.S1.02
Polar TM4 T 165 4x38 G.hns1 R 31 G.hns1.02
Polar TM3 D 151 3x49 G.H5 Y 235 G.H5.23
Hydrophobic TM3 D 151 3x49 G.H5 Y 235 G.H5.23
Van-der-waals TM3 D 151 3x49 G.H5 Y 235 G.H5.23
Hydrophobic TM3 I 156 3x54 G.H5 L 232 G.H5.20
Van-der-waals TM3 I 156 3x54 G.H5 L 232 G.H5.20
Hydrophobic ICL2 L 160 - G.H5 F 220 G.H5.08
Hydrophobic ICL2 P 159 - G.H5 I 227 G.H5.15
Van-der-waals ICL2 P 159 - G.H5 I 227 G.H5.15
Ionic TM6 R 299 6x30 G.H5 D 225 G.H5.13
Polar TM6 T 302 6x33 G.H5 L 237 G.H5.25
Hydrophobic TM6 T 302 6x33 G.H5 L 237 G.H5.25
Van-der-waals TM6 T 302 6x33 G.H5 L 237 G.H5.25
Hydrophobic TM3 A 155 3x53 G.H5 Y 235 G.H5.23
Van-der-waals TM3 A 155 3x53 G.H5 Y 235 G.H5.23
Hydrophobic TM6 L 306 6x37 G.H5 L 237 G.H5.25
Hydrophobic ICL2 L 160 - G.S3 V 71 G.S3.01
Polar TM3 A 155 3x53 G.H5 N 231 G.H5.19
Hydrophobic TM3 A 155 3x53 G.H5 N 231 G.H5.19
Van-der-waals TM3 A 155 3x53 G.H5 N 231 G.H5.19
Hydrophobic ICL2 P 159 - G.H5 L 228 G.H5.16
Hydrophobic ICL2 L 160 - G.H5 K 224 G.H5.12
Van-der-waals ICL2 L 160 - G.H5 K 224 G.H5.12