5-HT5A receptor - Go

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.8 Å

REFERENCE

PUBLICATION DATE

July 20, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

ENDOGENOUS LIGANDS

5-hydroxytryptamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM6 M 286 6x36 G.H5 G 223 G.H5.24
Hydrophobic TM3 R 139 3x50 G.H5 C 222 G.H5.23
Polar TM6 R 282 6x32 G.H5 Y 225 G.H5.26
Van-der-waals TM6 R 282 6x32 G.H5 Y 225 G.H5.26
Hydrophobic TM3 I 143 3x54 G.H5 L 219 G.H5.20
Van-der-waals TM3 I 143 3x54 G.H5 L 219 G.H5.20
Van-der-waals TM6 M 286 6x36 G.H5 G 223 G.H5.24
Polar TM6 R 282 6x32 G.H5 L 224 G.H5.25
Polar TM3 S 142 3x53 G.H5 N 218 G.H5.19
Hydrophobic TM3 S 142 3x53 G.H5 N 218 G.H5.19
Van-der-waals TM3 S 142 3x53 G.H5 N 218 G.H5.19
Hydrophobic TM5 A 227 5x65 G.H5 L 224 G.H5.25
Van-der-waals TM6 R 282 6x32 G.H5 L 224 G.H5.25
Hydrophobic TM6 M 286 6x36 G.H5 L 224 G.H5.25
Hydrophobic TM5 R 230 5x68 G.H5 I 215 G.H5.16
Ionic TM5 R 230 5x68 G.H5 D 212 G.H5.13
Polar TM5 R 230 5x68 G.H5 D 212 G.H5.13
Hydrophobic TM5 R 230 5x68 G.H5 D 212 G.H5.13
Van-der-waals TM5 R 230 5x68 G.H5 D 212 G.H5.13
Hydrophobic ICL2 P 146 - G.H5 T 211 G.H5.12
Hydrophobic TM4 L 151 4x35 G.hns1 A 28 G.hns1.02
Hydrophobic TM3 I 143 3x54 G.H5 I 215 G.H5.16
Hydrophobic TM6 K 279 6x29 G.H5 Y 225 G.H5.26
Van-der-waals TM6 K 279 6x29 G.H5 Y 225 G.H5.26
Hydrophobic TM4 L 151 4x35 G.hns1 K 29 G.hns1.03
Hydrophobic TM5 A 227 5x65 G.H5 L 219 G.H5.20
Polar TM6 R 282 6x32 G.H5 G 223 G.H5.24
Hydrophobic TM6 R 282 6x32 G.H5 G 223 G.H5.24
Hydrophobic TM5 R 230 5x68 G.H5 A 216 G.H5.17
Hydrophobic ICL2 M 147 - G.H5 V 210 G.H5.11
Ionic TM5 R 230 5x68 G.h4s6 E 189 G.h4s6.12
Hydrophobic TM5 I 223 5x61 G.H5 L 224 G.H5.25
Hydrophobic ICL2 M 147 - G.H5 T 211 G.H5.12
Van-der-waals ICL2 M 147 - G.H5 T 211 G.H5.12
Hydrophobic ICL2 M 147 - G.H5 I 214 G.H5.15
Van-der-waals ICL2 M 147 - G.H5 I 214 G.H5.15
Polar ICL3 V 231 - G.H5 Y 225 G.H5.26
Hydrophobic ICL2 P 146 - G.H5 I 215 G.H5.16
Hydrophobic TM3 I 143 3x54 G.H5 N 218 G.H5.19
Van-der-waals TM3 I 143 3x54 G.H5 N 218 G.H5.19
Polar TM5 A 227 5x65 G.H5 Y 225 G.H5.26
Hydrophobic TM5 A 227 5x65 G.H5 Y 225 G.H5.26
Van-der-waals TM5 A 227 5x65 G.H5 Y 225 G.H5.26
Hydrophobic ICL2 M 147 - G.S3 L 76 G.S3.01
Hydrophobic ICL2 P 146 - G.H5 I 214 G.H5.15