PDB
7UM6
Resolution
2.8 Å
Released
July 20, 2022
Receptor
5-HT5A
Class
A
Species
Homo sapiens
Ligand
Function
lisuride
Agonist (partial)
Reference
10.1038/S41594-022-00796-6

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Ligand Amino Acid Generic Number Segment Interaction Type
lisuride W117 3.28x28 TM3 hydrophobic
lisuride D121 3.32x32 TM3 hydrophobic
lisuride D121 3.32x32 TM3 polar (charge-charge)
lisuride D121 3.32x32 TM3 polar (hydrogen bond)
lisuride V122 3.33x33 TM3 Van der Waals
lisuride C125 3.36x36 TM3 hydrophobic
lisuride T126 3.37x37 TM3 Van der Waals
lisuride C192 45.50x50 ECL2 Van der Waals
lisuride V194 45.52x52 ECL2 Van der Waals
lisuride S204 5.42x43 TM5 Van der Waals
lisuride A208 5.46x461 TM5 Van der Waals
lisuride F301 6.51x51 TM6 hydrophobic
lisuride F302 6.52x52 TM6 aromatic (edge-to-face)
lisuride E305 6.55x55 TM6 Van der Waals
lisuride L324 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R T F H ICL1ECL1 R R W Q L ECL1ICL2 H M E Y T ICL2ECL2 W G E T Y S E G S E E C Q V S R ECL2ICL3 V S P I S E A V E V K D S A K Q P Q M V F T V R H A T V T F Q P E G D ICL3ECL3 S C D I ECL3N-term M D L P V N L T S F S L S T P S P L E T N H S L G K D D L R P S S P L N-termC-term S R Q H C-term L S V F G V L I L T L L G F L V A A T F A W N L L V L A T I L R V R V P H N L V A S M A V S D V L V A A L V M P L S L V H E L S G G R R L C Q L W I A C D V L C C T A S I W N V T A I A L D R Y W S I T R L R T R K C V S N V M I A L T W A L S A V I S L A P L L F G E P S Y A V F S T V G A F Y L P L C V V L F V Y W K I Y K A A K F R V G S R K T N S T W R E Q K E Q R A A L M V G I L I G V F V L C W I P F F L T E L I S P L C P A I W K S I F L W L G Y S N S F F N P L I Y T A F N K N F K N Y N S A F F
Helix box plot — Download: PNG | SVG L N W A F T A A V L F G L L T L I L V G 1 A S M A V S D V L V A L A V M P L S L V H 2 A T V N W I S A T C C L V D C A I W L Q 3 S N V M I A L T W A L S A V I S L A P L 4 Y V F L V V C L P L Y F A G V T S F V A Y 5 G I L I G V F V L C W I P F F L T E L I 6 L P N F F S N S Y G L W L F I S K W I 7

GPCRdb(A)
GPCRdb(A)
5-HT5A receptor
TM3
3x28 3.28x28 W117
3x32 3.32x32 D121
3x33 3.33x33 V122
3x36 3.36x36 C125
3x37 3.37x37 T126
ECL2
45x50 45.50x50 C192
45x52 45.52x52 V194
TM5
5x43 5.42x43 S204
5x461 5.46x461 A208
TM6
6x51 6.51x51 F301
6x52 6.52x52 F302
6x55 6.55x55 E305
TM7
7x38 7.39x38 L324