GPR161 (gp161_human)
FAMILY
Class A (Rhodopsin) Orphan receptors Class A orphans GPR161
GENE
GPR161
ORGANISM
Human (Homo sapiens)
ALT. NAMES
G-protein coupled receptor 161, G-protein coupled receptor RE2
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
S
|
L
|
N
|
S
|
S
|
L
|
S
|
C
|
R
|
10 |
K
|
E
|
L
|
S
|
N
|
L
|
T
|
E
|
E
|
E
|
20 |
TM1 | |||||||||
G
|
G
|
E
|
G
|
G
|
V
|
I
|
I
|
T
|
Q
|
30 |
F
|
I
|
A
|
I
|
I
|
V
|
I
|
T
|
I
|
F
|
40 |
V
|
C
|
L
|
G
|
N
|
L
|
V
|
I
|
V
|
V
|
50 |
ICL1 | |||||||||
T
|
L
|
Y
|
K
|
K
|
S
|
Y
|
L
|
L
|
T
|
60 |
TM2 | |||||||||
L
|
S
|
N
|
K
|
F
|
V
|
F
|
S
|
L
|
T
|
70 |
L
|
S
|
N
|
F
|
L
|
L
|
S
|
V
|
L
|
V
|
80 |
L
|
P
|
F
|
V
|
V
|
T
|
S
|
S
|
I
|
R
|
90 |
ECL1 | TM3 | ||||||||
R
|
E
|
W
|
I
|
F
|
G
|
V
|
V
|
W
|
C
|
100 |
N
|
F
|
S
|
A
|
L
|
L
|
Y
|
L
|
L
|
I
|
110 |
S
|
S
|
A
|
S
|
M
|
L
|
T
|
L
|
G
|
V
|
120 |
I
|
A
|
I
|
D
|
R
|
Y
|
Y
|
A
|
V
|
L
|
130 |
ICL2 | |||||||||
Y
|
P
|
M
|
V
|
Y
|
P
|
M
|
K
|
I
|
T
|
140 |
TM4 | |||||||||
G
|
N
|
R
|
A
|
V
|
M
|
A
|
L
|
V
|
Y
|
150 |
I
|
W
|
L
|
H
|
S
|
L
|
I
|
G
|
C
|
L
|
160 |
ECL2 | |||||||||
P
|
P
|
L
|
F
|
G
|
W
|
S
|
S
|
V
|
E
|
170 |
F
|
D
|
E
|
F
|
K
|
W
|
M
|
C
|
V
|
A
|
180 |
TM5 | |||||||||
A
|
W
|
H
|
R
|
E
|
P
|
G
|
Y
|
T
|
A
|
190 |
F
|
W
|
Q
|
I
|
W
|
C
|
A
|
L
|
F
|
P
|
200 |
F
|
L
|
V
|
M
|
L
|
V
|
C
|
Y
|
G
|
F
|
210 |
I
|
F
|
R
|
V
|
A
|
R
|
V
|
K
|
A
|
R
|
220 |
ICL3 | |||||||||
K
|
V
|
H
|
C
|
G
|
T
|
V
|
V
|
I
|
V
|
230 |
E
|
E
|
D
|
A
|
Q
|
R
|
T
|
G
|
R
|
K
|
240 |
N
|
S
|
S
|
T
|
S
|
T
|
S
|
S
|
S
|
G
|
250 |
S
|
R
|
R
|
N
|
A
|
F
|
Q
|
G
|
V
|
V
|
260 |
TM6 | |||||||||
Y
|
S
|
A
|
N
|
Q
|
C
|
K
|
A
|
L
|
I
|
270 |
T
|
I
|
L
|
V
|
V
|
L
|
G
|
A
|
F
|
M
|
280 |
V
|
T
|
W
|
G
|
P
|
Y
|
M
|
V
|
V
|
I
|
290 |
ECL3 | |||||||||
A
|
S
|
E
|
A
|
L
|
W
|
G
|
K
|
S
|
S
|
300 |
TM7 | |||||||||
V
|
S
|
P
|
S
|
L
|
E
|
T
|
W
|
A
|
T
|
310 |
W
|
L
|
S
|
F
|
A
|
S
|
A
|
V
|
C
|
H
|
320 |
H8 | |||||||||
P
|
L
|
I
|
Y
|
G
|
L
|
W
|
N
|
K
|
T
|
330 |
V
|
R
|
K
|
E
|
L
|
L
|
G
|
M
|
C
|
F
|
340 |
C-term | |||||||||
G
|
D
|
R
|
Y
|
Y
|
R
|
E
|
P
|
F
|
V
|
350 |
Q
|
R
|
Q
|
R
|
T
|
S
|
R
|
L
|
F
|
S
|
360 |
I
|
S
|
N
|
R
|
I
|
T
|
D
|
L
|
G
|
L
|
370 |
S
|
P
|
H
|
L
|
T
|
A
|
L
|
M
|
A
|
G
|
380 |
G
|
Q
|
P
|
L
|
G
|
H
|
S
|
S
|
S
|
T
|
390 |
G
|
D
|
T
|
G
|
F
|
S
|
C
|
S
|
Q
|
D
|
400 |
S
|
G
|
T
|
D
|
M
|
M
|
L
|
L
|
E
|
D
|
410 |
Y
|
T
|
S
|
D
|
D
|
N
|
P
|
P
|
S
|
H
|
420 |
C
|
T
|
C
|
P
|
P
|
K
|
R
|
R
|
S
|
S
|
430 |
V
|
T
|
F
|
E
|
D
|
E
|
V
|
E
|
Q
|
I
|
440 |
K
|
E
|
A
|
A
|
K
|
N
|
S
|
I
|
L
|
H
|
450 |
V
|
K
|
A
|
E
|
V
|
H
|
K
|
S
|
L
|
D
|
460 |
S
|
Y
|
A
|
A
|
S
|
L
|
A
|
K
|
A
|
I
|
470 |
E
|
A
|
E
|
A
|
K
|
I
|
N
|
L
|
F
|
G
|
480 |
E
|
E
|
A
|
L
|
P
|
G
|
V
|
L
|
V
|
T
|
490 |
A
|
R
|
T
|
V
|
P
|
G
|
G
|
G
|
F
|
G
|
500 |
G
|
R
|
R
|
G
|
S
|
R
|
T
|
L
|
V
|
S
|
510 |
Q
|
R
|
L
|
Q
|
L
|
Q
|
S
|
I
|
E
|
E
|
520 |
G
|
D
|
V
|
L
|
A
|
A
|
E
|
Q
|
R
|
LINKS
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
No physiological ligands available
STRUCTURE MODELS
STRUCTURES
Found 1 structure(s) - view all details on the Structures page
PDBs: 8KH4