GPR101 - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

C

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8W8Q

RESOLUTION

2.9 Å

REFERENCE

10.1038/S41589-023-01456-6

PUBLICATION DATE

Jan. 3, 2024

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

ENDOGENOUS LIGANDS

No endogenous ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 133 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM3 I 133 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM5 L 226 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 L 226 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM3 I 133 3x54 G.H5 L 393 G.H5.25
Hydrophobic TM2 V 65 2x38 G.hns1 R 38 G.hns1.02
Hydrophobic TM6 K 396 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 I 401 6x37 G.H5 L 393 G.H5.25
Aromatic TM3 R 129 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 129 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 129 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM6 K 396 6x32 G.H5 L 393 G.H5.25
Polar ICL2 L 137 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 137 - G.S1 H 41 G.S1.02
Polar ICL2 P 140 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 P 140 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 P 140 - G.hns1 R 38 G.hns1.02
Polar ICL2 M 143 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 M 143 - G.hns1 R 38 G.hns1.02
Polar TM2 Q 64 2x37 G.hns1 R 38 G.hns1.02
Hydrophobic TM2 Q 64 2x37 G.hns1 R 38 G.hns1.02
Van-der-waals TM2 Q 64 2x37 G.hns1 R 38 G.hns1.02
Hydrophobic TM5 Q 222 5x68 G.H5 L 394 G.H5.26
Hydrophobic TM3 I 133 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 I 133 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 137 - G.S3 V 217 G.S3.01
Polar H8 K 459 8x48 G.H5 Q 390 G.H5.22
Hydrophobic H8 K 459 8x48 G.H5 Q 390 G.H5.22
Van-der-waals H8 K 459 8x48 G.H5 Q 390 G.H5.22
Hydrophobic TM5 V 215 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 V 215 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM6 V 400 6x36 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 137 - G.H5 C 379 G.H5.11
Aromatic H8 H 458 8x47 G.H5 Y 391 G.H5.23
Hydrophobic H8 H 458 8x47 G.H5 Y 391 G.H5.23
Van-der-waals H8 H 458 8x47 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 137 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 137 - G.H5 I 383 G.H5.15
Hydrophobic H8 K 459 8x48 G.H5 R 389 G.H5.21
Ionic H8 K 462 8x51 G.H5 E 392 G.H5.24
Hydrophobic TM5 H 223 5x69 G.H5 L 394 G.H5.26
Hydrophobic TM5 A 219 5x65 G.H5 L 388 G.H5.20
Polar TM3 I 134 3x55 G.H5 R 380 G.H5.12
Hydrophobic H8 T 460 8x49 G.H5 Q 390 G.H5.22
Van-der-waals H8 T 460 8x49 G.H5 Q 390 G.H5.22
Hydrophobic TM5 L 226 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 L 226 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM7 M 457 7x56 G.H5 E 392 G.H5.24
Hydrophobic TM6 V 400 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 V 400 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM6 A 397 6x33 G.H5 L 393 G.H5.25
Polar TM3 S 132 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 S 132 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 S 132 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 136 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 136 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 L 137 - G.S3 F 219 G.S3.03
Van-der-waals ICL2 L 137 - G.S3 F 219 G.S3.03
Hydrophobic ICL2 L 137 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 L 137 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 L 137 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 137 - G.H5 F 376 G.H5.08
Hydrophobic TM4 T 144 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM5 A 218 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 A 218 5x64 G.H5 Q 384 G.H5.16
Polar H8 H 458 8x47 G.H5 Q 390 G.H5.22
Hydrophobic H8 H 458 8x47 G.H5 Q 390 G.H5.22
Hydrophobic H8 K 459 8x48 G.H5 E 392 G.H5.24
Polar ICL1 Q 61 12x49 G.HN K 34 G.HN.51
Hydrophobic ICL1 Q 61 12x49 G.HN K 34 G.HN.51
Ionic TM5 R 221 5x67 G.H5 D 381 G.H5.13
Polar TM5 R 221 5x67 G.H5 D 381 G.H5.13
Polar TM3 I 133 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 133 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 133 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 P 136 - G.H5 Q 384 G.H5.16
Hydrophobic TM5 L 226 5x72 G.H5 L 394 G.H5.26
Ionic TM6 K 396 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 K 396 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 396 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM4 T 144 4x38 G.hns1 R 38 G.hns1.02
Hydrophobic TM5 Q 222 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 Q 222 5x68 G.H5 R 385 G.H5.17
Polar ICL2 P 140 - G.HN Q 35 G.HN.52
Hydrophobic TM5 Q 222 5x68 G.H5 L 388 G.H5.20
Hydrophobic ICL2 P 140 - G.hns1 A 39 G.hns1.03