NPFF2 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Bos taurus

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

July 23, 2025

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

Neuropeptide VF - Agonist pubchem

PHYSIOLOGICAL LIGANDS

QRFP43 (43RFa) (Human), neuropeptide AF (Rat), neuropeptide AF (Human), RFRP-3 (Human), neuropeptide SF (Human), PrRP-31 (Human), neuropeptide AF (Mouse), neuropeptide FF (Human), RFRP-1 (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic ICL4 N 439 - G.H5 G 352 G.H5.24
Hydrophobic TM6 I 374 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 374 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 348 5x65 G.H5 I 344 G.H5.16
Hydrophobic ICL2 P 252 - G.H5 I 343 G.H5.15
Hydrophobic TM6 K 371 6x30 G.H5 F 354 G.H5.26
Hydrophobic TM3 R 245 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 245 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 249 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 249 3x54 G.H5 I 344 G.H5.16
Polar TM2 T 182 2x39 G.H5 C 351 G.H5.23
Polar TM3 C 248 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 C 248 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 C 248 3x53 G.H5 C 351 G.H5.23
Polar ICL4 N 439 - G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 252 - G.H5 I 344 G.H5.16
Hydrophobic TM6 L 378 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM6 I 374 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 I 374 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM7 F 438 7x56 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 255 - G.hns1 R 32 G.hns1.03
Hydrophobic H8 E 440 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 E 440 8x48 G.H5 F 354 G.H5.26
Van-der-waals ICL2 P 252 - G.H5 N 347 G.H5.19
Van-der-waals H8 N 441 8x49 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 373 6x32 G.H5 F 354 G.H5.26
Polar H8 N 441 8x49 G.H5 K 349 G.H5.21
Hydrophobic TM6 M 377 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 377 6x36 G.H5 L 353 G.H5.25
Polar TM3 D 244 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 D 244 3x49 G.H5 C 351 G.H5.23
Van-der-waals TM3 D 244 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 249 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM5 L 348 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 348 5x65 G.H5 L 348 G.H5.20
Polar TM3 R 245 3x50 G.H5 G 352 G.H5.24
Van-der-waals TM3 R 245 3x50 G.H5 G 352 G.H5.24
Hydrophobic ICL2 F 253 - G.S3 L 194 G.S3.01