SST2 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

Aug. 31, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

SOMATOSTATIN - Agonist chembl_ligand pubchem

ENDOGENOUS LIGANDS

SRIF-28, cortistatin-14, CST-17, SRIF-14



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Van-der-waals TM5 S 238 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 V 235 5x65 G.H5 L 348 G.H5.20
Polar TM3 A 143 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 143 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 143 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL3 V 242 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 V 242 - G.H5 D 337 G.H5.09
Hydrophobic H8 D 317 8x48 G.H5 F 354 G.H5.26
Hydrophobic ICL2 I 148 - G.S3 L 194 G.S3.01
Hydrophobic TM3 R 140 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 140 3x50 G.H5 C 351 G.H5.23
Van-der-waals H8 D 317 8x48 G.H5 K 349 G.H5.21
Hydrophobic ICL2 A 151 - G.hns1 R 32 G.hns1.03
Polar ICL3 G 239 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 G 239 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 G 239 - G.H5 D 341 G.H5.13
Hydrophobic TM6 V 258 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM6 S 250 6x29 G.H5 F 354 G.H5.26
Polar ICL3 S 245 - G.H5 D 341 G.H5.13
Van-der-waals H8 N 318 8x49 G.H5 K 349 G.H5.21
Hydrophobic ICL3 G 243 - G.H5 D 337 G.H5.09
Hydrophobic H8 S 316 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM3 V 144 3x54 G.H5 N 347 G.H5.19
Polar H8 N 318 8x49 G.H5 D 350 G.H5.22
Hydrophobic H8 N 318 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 N 318 8x49 G.H5 D 350 G.H5.22
Hydrophobic ICL2 I 148 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 P 147 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 147 - G.H5 I 344 G.H5.16
Hydrophobic TM3 V 144 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM3 V 144 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 144 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM2 T 78 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL2 K 152 - G.hns1 R 32 G.hns1.03
Polar TM2 T 78 2x39 G.H5 D 350 G.H5.22
Ionic TM4 R 155 4x38 G.HN E 28 G.HN.52
Polar TM4 R 155 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 R 155 4x38 G.HN E 28 G.HN.52
Hydrophobic TM5 I 231 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 147 - G.H5 T 340 G.H5.12
Hydrophobic TM6 V 254 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 254 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 V 254 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM3 R 140 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM5 I 231 5x61 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 147 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 147 - G.H5 I 343 G.H5.15