NTS1 receptor - G11

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

March 25, 2026

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

NTS8–13 - Agonist pubchem

PHYSIOLOGICAL LIGANDS

large neuromedin N (Mouse), neurotensin (Human), neuromedin N (Human), large neuromedin N (Human), large neuromedin N (Rat), large neurotensin (Human), neuromedin N (Mouse)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Polar TM3 R 166 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 166 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 166 3x50 G.H5 Y 356 G.H5.23
Polar TM3 A 169 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 169 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 169 3x53 G.H5 N 352 G.H5.19
Hydrophobic H8 S 368 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 S 368 8x47 G.H5 N 357 G.H5.24
Hydrophobic TM3 I 170 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 I 170 3x54 G.H5 L 353 G.H5.20
Hydrophobic TM6 L 298 6x30 G.H5 L 353 G.H5.20
Van-der-waals TM6 L 298 6x30 G.H5 L 353 G.H5.20
Hydrophobic ICL2 F 174 34x51 G.S1 L 40 G.S1.02
Hydrophobic TM2 V 101 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 V 101 2x39 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 P 173 34x50 G.H5 I 348 G.H5.15
Hydrophobic ICL2 F 174 34x51 G.H5 K 345 G.H5.12
Polar TM3 I 170 3x54 G.H5 Y 356 G.H5.23
Hydrophobic TM3 I 170 3x54 G.H5 Y 356 G.H5.23
Van-der-waals TM3 I 170 3x54 G.H5 Y 356 G.H5.23
Hydrophobic TM7 V 367 7x56 G.H5 N 357 G.H5.24
Van-der-waals TM7 V 367 7x56 G.H5 N 357 G.H5.24
Hydrophobic ICL2 P 173 34x50 G.H5 L 349 G.H5.16
Hydrophobic TM3 I 170 3x54 G.H5 L 358 G.H5.25
Hydrophobic ICL2 F 174 34x51 G.H5 I 348 G.H5.15
Van-der-waals ICL2 F 174 34x51 G.H5 I 348 G.H5.15
Hydrophobic TM5 M 266 5x68 G.H5 L 349 G.H5.16
Van-der-waals TM5 M 266 5x68 G.H5 L 349 G.H5.16
Hydrophobic TM6 A 297 6x29 G.H5 V 359 G.H5.26
Polar TM6 G 301 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM6 G 301 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 G 301 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM3 A 169 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 169 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM6 L 305 6x37 G.H5 L 358 G.H5.25
Van-der-waals TM6 L 305 6x37 G.H5 L 358 G.H5.25