GLP-1 receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Bos taurus

PDB CODE

7FIM

RESOLUTION

3.4 Å

REFERENCE

10.1038/S41467-022-28683-0

PUBLICATION DATE

March 2, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

92 interactions (Click to see)

LIGANDS

tirzepatide - Agonist pubchem gtoplig

PHYSIOLOGICAL LIGANDS

glucagon-like peptide 1-(7-37), glucagon, glucagon-like peptide 1-(7-36) amide



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 K 334 5x64 G.H5 L 388 G.H5.20
Van-der-waals TM5 K 334 5x64 G.H5 L 388 G.H5.20
Polar TM3 A 256 3x59 G.H5 R 380 G.H5.12
Van-der-waals TM3 A 256 3x59 G.H5 R 380 G.H5.12
Polar TM6 R 348 6x37 G.H5 L 394 G.H5.26
Hydrophobic TM6 R 348 6x37 G.H5 L 394 G.H5.26
Van-der-waals TM6 R 348 6x37 G.H5 L 394 G.H5.26
Polar TM3 L 255 3x58 G.H5 R 380 G.H5.12
Hydrophobic TM6 S 352 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 S 352 6x41 G.H5 L 393 G.H5.25
Van-der-waals H8 E 408 8x49 G.H5 E 392 G.H5.24
Hydrophobic H8 N 406 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 406 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM2 R 176 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 176 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM5 K 334 5x64 G.H5 L 394 G.H5.26
Hydrophobic TM3 L 255 3x58 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 251 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 251 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM5 V 331 5x61 G.H5 L 393 G.H5.25
Polar ICL2 F 257 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 F 257 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 257 - G.H5 R 380 G.H5.12
Polar TM3 L 255 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 255 3x58 G.H5 Q 384 G.H5.16
Polar TM4 E 262 4x39 G.HN Q 35 G.HN.52
Van-der-waals TM4 E 262 4x39 G.HN Q 35 G.HN.52
Hydrophobic TM5 V 331 5x61 G.H5 L 388 G.H5.20
Hydrophobic TM6 L 356 6x45 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 356 6x45 G.H5 L 393 G.H5.25
Polar TM5 K 334 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 334 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 K 334 5x64 G.H5 R 385 G.H5.17
Polar TM2 R 176 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM4 S 261 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 S 261 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM2 H 180 2x50 G.H5 Y 391 G.H5.23
Ionic TM5 K 334 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 334 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 334 5x64 G.H5 D 381 G.H5.13
Polar TM6 R 348 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM6 R 348 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM5 V 327 5x57 G.H5 L 393 G.H5.25
Hydrophobic ICL2 V 259 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 V 259 - G.hns1 R 38 G.hns1.02
Polar TM6 R 348 6x37 G.H5 E 392 G.H5.24
Van-der-waals TM6 R 348 6x37 G.H5 E 392 G.H5.24
Van-der-waals ICL2 S 258 - G.H5 R 380 G.H5.12
Polar TM5 K 334 5x64 G.H5 Q 384 G.H5.16
Ionic TM4 E 262 4x39 G.hns1 R 38 G.hns1.02
Polar TM3 L 254 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 254 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 255 3x58 G.H5 L 388 G.H5.20
Polar TM3 E 247 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 247 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 335 5x65 G.H5 L 394 G.H5.26