CX3CR1 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7XBX

RESOLUTION

3.4 Å

REFERENCE

PUBLICATION DATE

July 13, 2022

3D VIEW

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LIGAND INTERACTIONS

67 interactions (Click to see)

LIGANDS

CX3CL1 - Agonist

PHYSIOLOGICAL LIGANDS

CX3CL1



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM2 D 169 2x40 G.H5 G 352 G.H5.24
Hydrophobic TM2 D 169 2x40 G.H5 G 352 G.H5.24
Van-der-waals TM2 D 169 2x40 G.H5 G 352 G.H5.24
Ionic TM3 R 229 3x50 G.H5 D 350 G.H5.22
Polar TM3 R 229 3x50 G.H5 D 350 G.H5.22
Hydrophobic TM3 R 229 3x50 G.H5 D 350 G.H5.22
Van-der-waals TM3 R 229 3x50 G.H5 D 350 G.H5.22
Hydrophobic TM3 I 233 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 233 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM3 I 233 3x54 G.H5 N 347 G.H5.19
Hydrophobic ICL2 A 236 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 A 236 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM3 I 233 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 233 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 M 240 34x54 G.S1 V 34 G.S1.02
Polar ICL2 N 241 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 N 241 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 N 241 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic H8 K 401 8x49 G.H5 F 354 G.H5.26
Van-der-waals H8 K 401 8x49 G.H5 F 354 G.H5.26
Polar TM3 R 229 3x50 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 229 3x50 G.H5 N 347 G.H5.19
Van-der-waals TM3 R 229 3x50 G.H5 N 347 G.H5.19
Polar TM3 R 229 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 229 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 A 237 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 A 237 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM5 L 320 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 320 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 M 240 34x54 G.H5 I 343 G.H5.15
Van-der-waals ICL2 M 240 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM5 S 323 5x68 G.H5 D 341 G.H5.13
Polar H8 E 400 8x48 G.H5 L 353 G.H5.25
Van-der-waals H8 E 400 8x48 G.H5 L 353 G.H5.25
Ionic TM6 K 328 6x30 G.h4s6 E 318 G.h4s6.12
Hydrophobic H8 E 400 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 E 400 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM2 L 172 2x43 G.H5 G 352 G.H5.24
Polar TM3 A 232 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 232 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 232 3x53 G.H5 N 347 G.H5.19
Polar TM2 T 168 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 168 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 168 2x39 G.H5 D 350 G.H5.22
Hydrophobic ICL2 M 240 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 M 240 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 A 331 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 331 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM4 T 244 4x38 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 T 244 4x38 G.hns1 R 32 G.hns1.03
Hydrophobic TM2 T 168 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 168 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 L 172 2x43 G.H5 L 353 G.H5.25
Van-der-waals TM2 L 172 2x43 G.H5 L 353 G.H5.25
Polar H8 K 401 8x49 G.H5 L 353 G.H5.25
Hydrophobic H8 K 401 8x49 G.H5 L 353 G.H5.25
Van-der-waals H8 K 401 8x49 G.H5 L 353 G.H5.25
Hydrophobic ICL4 G 399 - G.H5 L 353 G.H5.25
Van-der-waals ICL4 G 399 - G.H5 L 353 G.H5.25
Hydrophobic TM6 K 328 6x30 G.H5 L 348 G.H5.20
Van-der-waals TM6 K 328 6x30 G.H5 L 348 G.H5.20
Hydrophobic ICL2 A 237 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 A 237 34x51 G.H5 F 336 G.H5.08
Polar ICL2 N 241 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 N 241 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM6 L 334 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 334 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM5 T 319 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 T 319 5x64 G.H5 I 344 G.H5.16
Polar H8 F 402 8x50 G.H5 L 353 G.H5.25
Hydrophobic H8 F 402 8x50 G.H5 L 353 G.H5.25
Van-der-waals H8 F 402 8x50 G.H5 L 353 G.H5.25
Polar TM2 S 166 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 S 166 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM7 Y 395 7x53 G.H5 L 353 G.H5.25
Van-der-waals TM7 Y 395 7x53 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 331 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 A 331 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM2 D 169 2x40 G.H5 C 351 G.H5.23
Hydrophobic TM6 I 332 6x34 G.H5 L 348 G.H5.20
Hydrophobic TM4 T 244 4x38 G.HN E 28 G.HN.52
Hydrophobic TM6 L 334 6x36 G.H5 F 354 G.H5.26
Hydrophobic TM6 A 331 6x33 G.H5 C 351 G.H5.23
Van-der-waals TM6 A 331 6x33 G.H5 C 351 G.H5.23
Van-der-waals ICL3 N 325 - G.H5 I 344 G.H5.16
Hydrophobic ICL4 G 399 - G.H5 F 354 G.H5.26
Hydrophobic ICL2 M 240 34x54 G.S3 L 194 G.S3.01
Van-der-waals ICL2 M 240 34x54 G.S3 L 194 G.S3.01