Structure information

CX3CR1

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7XBX

SPECIES

Homo sapiens

RESOLUTION

3.400

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

July 13, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CX3CL1 Y124 N-term polar (hydrogen bond)
CX3CL1 I125 N-term polar (hydrogen bond)
CX3CL1 I125 N-term polar (hydrogen bond with backbone)
CX3CL1 G126 N-term polar (hydrogen bond)
CX3CL1 G126 N-term polar (hydrogen bond with backbone)
CX3CL1 V129 1.28x28 TM1 polar (hydrogen bond)
CX3CL1 W189 2.60x60 TM2 aromatic (face-to-face)
CX3CL1 W189 2.60x60 TM2 Van der Waals
CX3CL1 L193 2.64x64 TM2 hydrophobic
CX3CL1 L193 2.64x64 TM2 Van der Waals
CX3CL1 T208 3.29x29 TM3 Van der Waals
CX3CL1 F211 3.32x32 TM3 Van der Waals
CX3CL1 F211 3.32x32 TM3 aromatic (face-to-edge)
CX3CL1 F212 3.33x33 TM3 polar (hydrogen bond)
CX3CL1 Q266 4.60x61 TM4 Van der Waals
CX3CL1 Q266 4.60x61 TM4 polar (hydrogen bond with backbone)
CX3CL1 T270 ECL2 polar (hydrogen bond)
CX3CL1 K273 ECL2 polar (charge-assisted hydrogen bond)
CX3CL1 C277 45.50x50 ECL2 Van der Waals
CX3CL1 C278 45.51x51 ECL2 polar (hydrogen bond)
CX3CL1 G279 45.52x52 ECL2 polar (hydrogen bond)
CX3CL1 R293 5.38x39 TM5 polar (charge-assisted hydrogen bond)
CX3CL1 N294 5.39x40 TM5 polar (hydrogen bond)
CX3CL1 I353 6.55x55 TM6 Van der Waals
CX3CL1 P365 ECL3 polar (hydrogen bond with backbone)
CX3CL1 P365 ECL3 Van der Waals
CX3CL1 C367 7.25x24 TM7 Van der Waals
CX3CL1 R370 7.28x27 TM7 polar (charge-assisted hydrogen bond)
CX3CL1 L377 7.35x34 TM7 polar (hydrogen bond)
CX3CL1 S378 7.36x35 TM7 Van der Waals
CX3CL1 E381 7.39x38 TM7 polar (charge-assisted hydrogen bond)

Ligands

CX3CL1

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Residue Diagrams

L N G V L G I A F I V S Y F I S L F V T 1 L N L A L S D L L F V A T L P F W T H Y 2 V T I F F I S G F F G I F F F A T T F K 3 G V T I S L G V W A A A I L V A A P Q 4 Y C Y S M I L L P L L F G L F N T E V N R 5 L L V V I V F F L F W T P Y N V M I F L 6 L P N L C C H S F A V T E T V S L A L 7
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ICL1 K K P K ICL1ECL1 E K G L H N A ECL1ICL2 A A N S M N N R ICL2ECL2 K Q K E N E C L G D Y P E V ECL2ICL3 K N ICL3ECL3 F F P ECL3N-term M D Q F P E S V T E N F E Y D D L A E A C Y N-termC-term C L A V L C G R S V H V D F S S S E S Q R S R H G S V L S S N F T Y H T S D G D A L L L L C-term I G D I V V F G T V F L S I F Y S V I F A I G L V G N L L V V F A L T N S S V T D I Y L L N L A L S D L L F V A T L P F W T H Y L I N M C K F T T A F F F I G F F G S I F F I T V I S I D R Y L A I V L T V Q H G V T I S L G V W A A A I L V A A P Q F M F T L Q E I W P V L R N V E T N F L G F L L P L L I M S Y C Y F R I I Q T L F S C H K K A K A I K L I L L V V I V F F L F W T P Y N V M I F L E T L K L Y D S C D M R K D L R L A L S V T E T V A F S H C C L N P L I Y A F A G E K L Y H F R R Y L Y G K
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Residue Table


GPCRdb(A)
GPCRdb(A)
CX3CR1
TM1
1x28 1.28x28 V27
TM2
2x60 2.60x60 W87
2x64 2.64x64 L91
TM3
3x29 3.29x29 T106
3x32 3.32x32 F109
3x33 3.33x33 F110
TM4
4x61 4.60x61 Q164
ECL2
45x50 45.50x50 C175
45x51 45.51x51 L176
45x52 45.52x52 G177
TM5
5x39 5.38x39 R191
5x40 5.39x40 N192
TM6
6x55 6.55x55 I251
TM7
7x24 7.25x24 C265
7x27 7.28x27 R268
7x34 7.35x34 L275
7x35 7.36x35 S276
7x38 7.39x38 E279