GPR84 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

Nov. 1, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

6-Octylimino-1,3-diazinane-2,4-dione - Agonist pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM5 V 205 5x65 G.H5 I 344 G.H5.16
Hydrophobic ICL3 L 212 - G.H5 A 338 G.H5.10
Hydrophobic TM6 V 317 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 122 3x54 G.H5 L 348 G.H5.20
Polar H8 Q 376 8x49 G.H5 D 350 G.H5.22
Hydrophobic H8 Q 376 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 Q 376 8x49 G.H5 D 350 G.H5.22
Polar TM3 L 121 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 L 121 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 L 121 3x53 G.H5 N 347 G.H5.19
Van-der-waals ICL4 M 373 - G.H5 F 354 G.H5.26
Hydrophobic ICL3 L 212 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 L 212 - G.S6 Y 320 G.S6.02
Hydrophobic TM6 M 320 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 320 6x36 G.H5 L 353 G.H5.25
Hydrophobic H8 R 375 8x48 G.H5 K 349 G.H5.21
Hydrophobic TM3 L 121 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 L 121 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM5 A 208 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 A 208 5x68 G.H5 I 344 G.H5.16
Van-der-waals ICL3 Y 215 - G.H5 Q 333 G.H5.05
Hydrophobic TM6 V 317 6x33 G.H5 F 354 G.H5.26
Aromatic ICL3 Y 215 - G.H5 F 334 G.H5.06
Hydrophobic ICL3 Y 215 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 Y 215 - G.H5 F 334 G.H5.06
Hydrophobic ICL2 K 126 - G.hns1 R 32 G.hns1.03
Hydrophobic TM3 I 122 3x54 G.H5 L 353 G.H5.25
Polar TM3 R 118 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 118 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 118 3x50 G.H5 C 351 G.H5.23
Ionic TM2 R 54 2x38 G.HN E 28 G.HN.52
Polar TM2 R 54 2x38 G.HN E 28 G.HN.52
Polar H8 N 374 8x47 G.H5 C 351 G.H5.23
Hydrophobic H8 N 374 8x47 G.H5 C 351 G.H5.23
Van-der-waals H8 N 374 8x47 G.H5 C 351 G.H5.23
Polar ICL3 Y 215 - G.H5 D 337 G.H5.09
Hydrophobic ICL3 Y 215 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 Y 215 - G.H5 D 337 G.H5.09
Hydrophobic TM5 I 201 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 122 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM6 K 316 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM3 R 118 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM5 V 205 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 V 205 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM5 Q 204 5x64 G.H5 I 344 G.H5.16
Hydrophobic ICL2 P 125 - G.hns1 R 32 G.hns1.03
Hydrophobic TM5 Y 198 5x58 G.H5 L 353 G.H5.25
Hydrophobic TM6 C 321 6x37 G.H5 L 353 G.H5.25
Polar H8 N 374 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 N 374 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 N 374 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL3 L 212 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 L 212 - G.H5 D 341 G.H5.13
Aromatic ICL3 Y 215 - G.S6 H 322 G.S6.04
Hydrophobic ICL3 Y 215 - G.S6 H 322 G.S6.04
Polar H8 R 375 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 R 375 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 R 375 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM5 A 211 5x71 G.H5 D 337 G.H5.09
Hydrophobic ICL3 L 212 - G.H5 D 337 G.H5.09
Polar ICL3 Q 214 - G.H5 D 337 G.H5.09
Hydrophobic TM2 F 55 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 F 55 2x39 G.H5 C 351 G.H5.23