ADGRG3 - Go

GPCR CLASS (FAMILY)

Class B2 (Adhesion)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

Feb. 3, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

HYDROCORTISONE - Agonist chembl_ligand pubchem

ENDOGENOUS LIGANDS

No endogenous ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM5 T 464 5x68 G.S6 Y 320 G.S6.02
Hydrophobic TM7 L 524 7x60 G.H5 C 351 G.H5.23
Hydrophobic TM5 T 464 5x68 G.H5 D 337 G.H5.09
Hydrophobic TM6 K 475 6x38 G.H5 L 348 G.H5.20
Hydrophobic ICL2 F 371 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 F 371 - G.H5 I 343 G.H5.15
Ionic ICL3 R 469 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 V 370 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 V 370 - G.H5 I 344 G.H5.16
Hydrophobic TM6 N 472 6x35 G.H5 A 345 G.H5.17
Van-der-waals TM6 N 472 6x35 G.H5 A 345 G.H5.17
Hydrophobic TM3 L 363 3x54 G.H5 L 348 G.H5.20
Polar TM6 N 472 6x35 G.H5 D 341 G.H5.13
Hydrophobic TM6 N 472 6x35 G.H5 D 341 G.H5.13
Van-der-waals TM6 N 472 6x35 G.H5 D 341 G.H5.13
Hydrophobic TM5 I 457 5x61 G.H5 I 344 G.H5.16
Van-der-waals TM5 I 457 5x61 G.H5 I 344 G.H5.16
Hydrophobic TM6 V 476 6x39 G.H5 L 348 G.H5.20
Hydrophobic TM5 K 456 5x60 G.H5 T 340 G.H5.12
Hydrophobic TM3 A 367 3x58 G.H5 L 348 G.H5.20
Hydrophobic TM5 L 460 5x64 G.H5 I 344 G.H5.16
Polar TM6 K 474 6x37 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 474 6x37 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 F 371 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 F 371 - G.H5 T 340 G.H5.12
Ionic TM6 K 471 6x34 G.h4s6 E 318 G.h4s6.12
Polar TM6 K 471 6x34 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 K 471 6x34 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM7 L 524 7x60 G.H5 G 352 G.H5.24
Van-der-waals TM7 L 524 7x60 G.H5 G 352 G.H5.24
Ionic ICL3 R 469 - G.H4 E 309 G.H4.16
Polar ICL3 R 469 - G.H4 E 309 G.H4.16
Hydrophobic TM6 K 475 6x38 G.H5 L 353 G.H5.25
Van-der-waals TM6 K 475 6x38 G.H5 L 353 G.H5.25
Polar ICL2 N 372 - G.hns1 K 32 G.hns1.03
Hydrophobic TM5 L 460 5x64 G.H5 D 341 G.H5.13
Hydrophobic ICL3 V 466 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 V 466 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 V 370 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 V 370 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 F 371 - G.S3 L 195 G.S3.01
Hydrophobic TM5 K 456 5x60 G.H5 I 344 G.H5.16
Hydrophobic TM3 A 367 3x58 G.H5 I 344 G.H5.16
Hydrophobic ICL2 Y 374 - G.HN I 28 G.HN.52
Hydrophobic TM5 L 460 5x64 G.H5 T 340 G.H5.12
Van-der-waals TM5 L 460 5x64 G.H5 T 340 G.H5.12
Hydrophobic TM5 T 464 5x68 G.H5 D 341 G.H5.13
Hydrophobic ICL3 V 466 - G.S6 Y 320 G.S6.02
Hydrophobic ICL2 F 371 - G.H5 V 339 G.H5.11
Hydrophobic TM5 A 463 5x67 G.H5 D 337 G.H5.09
Hydrophobic TM6 L 479 6x42 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 479 6x42 G.H5 L 353 G.H5.25
Hydrophobic TM3 L 366 3x57 G.H5 C 351 G.H5.23
Van-der-waals TM3 L 366 3x57 G.H5 C 351 G.H5.23
Hydrophobic ICL2 V 370 - G.H5 T 340 G.H5.12
Polar TM7 W 520 7x56 G.H5 C 351 G.H5.23
Hydrophobic ICL2 F 371 - G.H5 F 336 G.H5.08
Hydrophobic TM6 N 472 6x35 G.H5 I 344 G.H5.16
Polar TM6 K 475 6x38 G.H5 Y 354 G.H5.26
Hydrophobic TM6 K 475 6x38 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 475 6x38 G.H5 Y 354 G.H5.26
Hydrophobic TM6 K 475 6x38 G.H5 R 349 G.H5.21
Polar TM3 L 366 3x57 G.H5 N 347 G.H5.19
Hydrophobic TM3 L 366 3x57 G.H5 N 347 G.H5.19
Van-der-waals TM3 L 366 3x57 G.H5 N 347 G.H5.19