PDB
7D77
Resolution
2.9 Å
Released
Feb. 3, 2021
Receptor
ADGRG3
Class
B2
Species
Homo sapiens
Ligand
Function
cortisol
Agonist
Reference
10.1038/S41586-020-03083-W

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Ligand Amino Acid Generic Number Segment Interaction Type
cortisol L319 2.60x60 TM2 Van der Waals
cortisol F323 2.64x64 TM2 hydrophobic
cortisol F345 3.36x36 TM3 hydrophobic
cortisol I408 ECL2 hydrophobic
cortisol L419 ECL2 hydrophobic
cortisol W421 45.51x51 ECL2 Van der Waals
cortisol W490 6.53x53 TM6 Van der Waals
cortisol A493 6.56x56 TM6 Van der Waals
cortisol L498 ECL3 hydrophobic
cortisol N510 7.46x45 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 E R F K S ICL1ECL1 G S K G ECL1ICL2 V F N T Y F G ICL2ECL2 S Y G L Y T I R D R E N R T S L E L C W F R E G T T M ECL2ICL3 A V K E R G ICL3ECL3 T P L G L S ECL3N-term M A T P R G L G A L L L L L L L P T S G Q E K P T E G P R N T C L G S N N M Y D N-termC-term L P S Q S T T V S S S T A R L D Q A H S A S Q E C-term D Q S T V H I L T R I S Q A G C G V S M I F L A F T I I L Y A F L R L S R E D A P K I H V A L G G S L F L L N L A F L V N V G S S D A A C W A R G A V F H Y F L L C A F T W M G L E A F H L Y L L A V R H Y F L K L S L V G W G L P A L M V I G T G S A N Y A L Y I T V H G Y F L I T F L F G M V V L A L V V W K I F T L S R A T K N R K K V L T L L G L S S L V G V T W G L A I F T V Y I F A L F N S L Q G V F I C C W F T I L Y
Helix box plot — Download: PNG | SVG A L F I M S V G C G A Q S I R T L I H V 1 V A L G G S L F L L N L A F L V N V G S 2 L G M W T F A C L L F Y H F V A G R A W 3 Y F L K L S L G V W G L P A L M V I G T G 4 L V V M G F L F T I L F Y G H V T I Y L A 5 L G L S S L V G V T W G L A I F 6 C C I F V G Q L S N F L A F I Y V T 7

GPCRdb(A)
GPCRdb(B)
ADGRG3
TM2
2x53 2.60x60 L319
2x57 2.64x64 F323
TM3
3x32 3.36x36 F345
ECL2
45x51 45.51x51 W421
TM6
6x48 6.53x53 W490
6x51 6.56x56 A493
TM7
7x41 7.46x45 N510