GPR75 - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9XQC

RESOLUTION

3.0 Å

REFERENCE

10.1038/S41401-025-01720-6

PUBLICATION DATE

Feb. 4, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) -

PHYSIOLOGICAL LIGANDS

CCL5 (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM7 S 377 7x54 G.H5 Y 358 G.H5.23
Polar ICL4 N 379 - G.H5 R 356 G.H5.21
Hydrophobic ICL1 K 74 - G.S3 V 194 G.S3.01
Van-der-waals ICL1 K 74 - G.S3 V 194 G.S3.01
Polar ICL1 K 74 - G.s2s3 K 193 G.s2s3.02
Hydrophobic ICL1 K 74 - G.s2s3 K 193 G.s2s3.02
Hydrophobic TM1 P 70 1x60 G.hns1 R 31 G.hns1.02
Aromatic TM2 F 79 2x39 G.H5 Y 358 G.H5.23
Hydrophobic TM2 F 79 2x39 G.H5 Y 358 G.H5.23
Van-der-waals TM2 F 79 2x39 G.H5 Y 358 G.H5.23
Hydrophobic TM3 R 143 3x50 G.H5 L 360 G.H5.25
Van-der-waals TM3 R 143 3x50 G.H5 L 360 G.H5.25
Hydrophobic ICL2 R 154 - G.H5 L 351 G.H5.16
Polar ICL4 N 379 - G.H5 E 357 G.H5.22
Hydrophobic ICL4 N 379 - G.H5 E 357 G.H5.22
Van-der-waals ICL4 N 379 - G.H5 E 357 G.H5.22
Hydrophobic TM3 M 146 3x53 G.H5 L 355 G.H5.20
Hydrophobic ICL1 F 75 - G.H5 F 343 G.H5.08
Hydrophobic ICL1 F 75 - G.S3 V 194 G.S3.01
Ionic ICL4 R 378 - G.H5 E 357 G.H5.22
Polar ICL4 R 378 - G.H5 E 357 G.H5.22
Hydrophobic ICL4 R 378 - G.H5 E 357 G.H5.22
Van-der-waals ICL4 R 378 - G.H5 E 357 G.H5.22
Polar TM2 D 80 2x40 G.H5 Y 358 G.H5.23
Hydrophobic ICL1 A 71 - G.hns1 R 31 G.hns1.02
Hydrophobic TM2 I 83 2x43 G.H5 Y 358 G.H5.23
Polar ICL4 N 379 - G.H5 N 359 G.H5.24
Hydrophobic ICL4 N 379 - G.H5 N 359 G.H5.24
Van-der-waals ICL4 N 379 - G.H5 N 359 G.H5.24
Hydrophobic ICL1 F 75 - G.S1 L 34 G.S1.02
Hydrophobic TM1 P 70 1x60 G.hns1 R 32 G.hns1.03
Hydrophobic ICL1 F 75 - G.H5 I 350 G.H5.15
Van-der-waals ICL1 F 75 - G.H5 I 350 G.H5.15
Hydrophobic TM2 F 79 2x39 G.H5 L 360 G.H5.25
Van-der-waals TM2 F 79 2x39 G.H5 L 360 G.H5.25
Hydrophobic ICL1 F 75 - G.H5 K 347 G.H5.12
Ionic ICL2 R 154 - G.H5 D 348 G.H5.13
Polar ICL2 R 154 - G.H5 D 348 G.H5.13
Polar ICL4 R 378 - G.H5 Y 358 G.H5.23
Hydrophobic ICL4 R 378 - G.H5 Y 358 G.H5.23
Van-der-waals ICL4 R 378 - G.H5 Y 358 G.H5.23
Hydrophobic ICL1 F 75 - G.H5 L 351 G.H5.16
Polar ICL4 R 378 - G.H5 N 354 G.H5.19
Van-der-waals ICL4 R 378 - G.H5 N 354 G.H5.19
Hydrophobic TM7 Y 376 7x53 G.H5 Y 358 G.H5.23
Van-der-waals TM7 Y 376 7x53 G.H5 Y 358 G.H5.23