C3a receptor - Go

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

C

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8I9L

RESOLUTION

3.2 Å

REFERENCE

10.1016/J.CELL.2023.09.020

PUBLICATION DATE

Oct. 18, 2023

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

C3a anaphylatoxin - Agonist pubchem

PHYSIOLOGICAL LIGANDS

C5a, C3a



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 V 124 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 124 3x54 G.H5 L 348 G.H5.20
Hydrophobic H8 G 439 8x47 G.H5 G 352 G.H5.24
Polar ICL2 N 132 - G.s2s3 N 194 G.s2s3.02
Van-der-waals ICL2 N 132 - G.s2s3 N 194 G.s2s3.02
Hydrophobic ICL2 P 127 - G.H5 T 340 G.H5.12
Hydrophobic TM3 V 123 3x53 G.H5 C 351 G.H5.23
Polar TM3 D 119 3x49 G.H5 C 351 G.H5.23
Hydrophobic ICL3 F 368 - G.H5 I 344 G.H5.16
Polar ICL3 S 371 - G.H5 Y 354 G.H5.26
Hydrophobic ICL3 S 371 - G.H5 Y 354 G.H5.26
Van-der-waals ICL3 S 371 - G.H5 Y 354 G.H5.26
Hydrophobic TM5 I 359 5x61 G.H5 L 348 G.H5.20
Polar ICL3 R 367 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 R 367 - G.S6 Y 320 G.S6.02
Ionic TM5 R 362 5x64 G.H5 D 341 G.H5.13
Polar ICL3 R 367 - G.h4s6 N 316 G.h4s6.10
Hydrophobic ICL3 F 368 - G.H5 A 345 G.H5.17
Polar TM3 V 123 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 V 123 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 V 123 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 Q 131 - G.S1 V 34 G.S1.02
Van-der-waals ICL2 Q 131 - G.S1 V 34 G.S1.02
Polar ICL3 R 367 - G.H5 Y 354 G.H5.26
Van-der-waals ICL3 R 367 - G.H5 Y 354 G.H5.26
Hydrophobic ICL4 L 438 - G.H5 G 352 G.H5.24
Van-der-waals ICL4 L 438 - G.H5 G 352 G.H5.24
Hydrophobic ICL3 F 368 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 F 368 - G.H5 D 341 G.H5.13
Ionic ICL3 R 367 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 R 367 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 367 - G.H5 D 341 G.H5.13
Hydrophobic TM4 N 135 4x38 G.HN I 28 G.HN.52
Van-der-waals TM4 N 135 4x38 G.HN I 28 G.HN.52
Hydrophobic ICL2 Q 131 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 Q 131 - G.H5 I 343 G.H5.15
Hydrophobic TM6 V 378 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 127 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 127 - G.H5 I 344 G.H5.16
Hydrophobic ICL2 Q 131 - G.S3 L 195 G.S3.01
Van-der-waals ICL2 Q 131 - G.S3 L 195 G.S3.01
Polar ICL2 N 132 - G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 N 132 - G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 N 132 - G.hns1 K 32 G.hns1.03
Polar TM2 N 57 2x39 G.H5 G 350 G.H5.22
Van-der-waals TM2 N 57 2x39 G.H5 G 350 G.H5.22
Polar TM3 R 120 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 120 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 120 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 124 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 124 3x54 G.H5 I 344 G.H5.16
Hydrophobic ICL3 R 367 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 367 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 R 367 - G.H5 A 345 G.H5.17
Van-der-waals ICL3 R 367 - G.H5 A 345 G.H5.17
Polar TM6 T 375 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 375 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 375 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL3 F 368 - G.H5 Y 354 G.H5.26
Van-der-waals ICL3 F 368 - G.H5 Y 354 G.H5.26
Hydrophobic ICL2 P 127 - G.H5 I 343 G.H5.15
Polar TM6 K 374 6x32 G.H5 G 352 G.H5.24
Polar ICL2 Q 131 - G.hns1 A 31 G.hns1.02
Hydrophobic TM5 I 359 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 359 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 120 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM5 Y 356 5x58 G.H5 L 353 G.H5.25
Hydrophobic TM5 R 362 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 362 5x64 G.H5 I 344 G.H5.16