C3a receptor (c3ar_human)
FAMILY
Class A (Rhodopsin) Peptide receptors Complement peptide receptors C3a receptor
GENE
C3AR1 (AZ3B, C3R1, HNFAG09)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
C3a anaphylatoxin chemotactic receptor, C3AR, C3a-R
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
S
|
F
|
S
|
A
|
E
|
T
|
N
|
S
|
10 |
T
|
D
|
L
|
L
|
S
|
Q
|
P
|
W
|
N
|
E
|
20 |
TM1 | |||||||||
P
|
P
|
V
|
I
|
L
|
S
|
M
|
V
|
I
|
L
|
30 |
S
|
L
|
T
|
F
|
L
|
L
|
G
|
L
|
P
|
G
|
40 |
N
|
G
|
L
|
V
|
L
|
W
|
V
|
A
|
G
|
L
|
50 |
ICL1 | TM2 | ||||||||
K
|
M
|
Q
|
R
|
T
|
V
|
N
|
T
|
I
|
W
|
60 |
F
|
L
|
H
|
L
|
T
|
L
|
A
|
D
|
L
|
L
|
70 |
C
|
C
|
L
|
S
|
L
|
P
|
F
|
S
|
L
|
A
|
80 |
ECL1 | |||||||||
H
|
L
|
A
|
L
|
Q
|
G
|
Q
|
W
|
P
|
Y
|
90 |
TM3 | |||||||||
G
|
R
|
F
|
L
|
C
|
K
|
L
|
I
|
P
|
S
|
100 |
I
|
I
|
V
|
L
|
N
|
M
|
F
|
A
|
S
|
V
|
110 |
F
|
L
|
L
|
T
|
A
|
I
|
S
|
L
|
D
|
R
|
120 |
ICL2 | |||||||||
C
|
L
|
V
|
V
|
F
|
K
|
P
|
I
|
W
|
C
|
130 |
TM4 | |||||||||
Q
|
N
|
H
|
R
|
N
|
V
|
G
|
M
|
A
|
C
|
140 |
S
|
I
|
C
|
G
|
C
|
I
|
W
|
V
|
V
|
A
|
150 |
F
|
V
|
M
|
C
|
I
|
P
|
V
|
F
|
V
|
Y
|
160 |
ECL2 | |||||||||
R
|
E
|
I
|
F
|
T
|
T
|
D
|
N
|
H
|
N
|
170 |
R
|
C
|
G
|
Y
|
K
|
F
|
G
|
L
|
S
|
S
|
180 |
S
|
L
|
D
|
Y
|
P
|
D
|
F
|
Y
|
G
|
D
|
190 |
P
|
L
|
E
|
N
|
R
|
S
|
L
|
E
|
N
|
I
|
200 |
V
|
Q
|
P
|
P
|
G
|
E
|
M
|
N
|
D
|
R
|
210 |
L
|
D
|
P
|
S
|
S
|
F
|
Q
|
T
|
N
|
D
|
220 |
H
|
P
|
W
|
T
|
V
|
P
|
T
|
V
|
F
|
Q
|
230 |
P
|
Q
|
T
|
F
|
Q
|
R
|
P
|
S
|
A
|
D
|
240 |
S
|
L
|
P
|
R
|
G
|
S
|
A
|
R
|
L
|
T
|
250 |
S
|
Q
|
N
|
L
|
Y
|
S
|
N
|
V
|
F
|
K
|
260 |
P
|
A
|
D
|
V
|
V
|
S
|
P
|
K
|
I
|
P
|
270 |
S
|
G
|
F
|
P
|
I
|
E
|
D
|
H
|
E
|
T
|
280 |
S
|
P
|
L
|
D
|
N
|
S
|
D
|
A
|
F
|
L
|
290 |
S
|
T
|
H
|
L
|
K
|
L
|
F
|
P
|
S
|
A
|
300 |
S
|
S
|
N
|
S
|
F
|
Y
|
E
|
S
|
E
|
L
|
310 |
P
|
Q
|
G
|
F
|
Q
|
D
|
Y
|
Y
|
N
|
L
|
320 |
G
|
Q
|
F
|
T
|
D
|
D
|
D
|
Q
|
V
|
P
|
330 |
TM5 | |||||||||
T
|
P
|
L
|
V
|
A
|
I
|
T
|
I
|
T
|
R
|
340 |
L
|
V
|
V
|
G
|
F
|
L
|
L
|
P
|
S
|
V
|
350 |
I
|
M
|
I
|
A
|
C
|
Y
|
S
|
F
|
I
|
V
|
360 |
ICL3 | |||||||||
F
|
R
|
M
|
Q
|
R
|
G
|
R
|
F
|
A
|
K
|
370 |
TM6 | |||||||||
S
|
Q
|
S
|
K
|
T
|
F
|
R
|
V
|
A
|
V
|
380 |
V
|
V
|
V
|
A
|
V
|
F
|
L
|
V
|
C
|
W
|
390 |
T
|
P
|
Y
|
H
|
I
|
F
|
G
|
V
|
L
|
S
|
400 |
ECL3 | TM7 | ||||||||
L
|
L
|
T
|
D
|
P
|
E
|
T
|
P
|
L
|
G
|
410 |
K
|
T
|
L
|
M
|
S
|
W
|
D
|
H
|
V
|
C
|
420 |
I
|
A
|
L
|
A
|
S
|
A
|
N
|
S
|
C
|
F
|
430 |
H8 | |||||||||
N
|
P
|
F
|
L
|
Y
|
A
|
L
|
L
|
G
|
K
|
440 |
D
|
F
|
R
|
K
|
K
|
A
|
R
|
Q
|
S
|
I
|
450 |
C-term | |||||||||
Q
|
G
|
I
|
L
|
E
|
A
|
A
|
F
|
S
|
E
|
460 |
E
|
L
|
T
|
R
|
S
|
T
|
H
|
C
|
P
|
S
|
470 |
N
|
N
|
V
|
I
|
S
|
E
|
R
|
N
|
S
|
T
|
480 |
T
|
V
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
C5a, C3a