C3a receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8IA8

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

May 24, 2023

3D VIEW

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LIGAND INTERACTIONS

37 interactions (Click to see)

LIGANDS

ALA-SER-LYS-LEU-GLY-LEU-ALA-ARG - Agonist

PHYSIOLOGICAL LIGANDS

C5a, C3a



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic ICL3 K 370 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 K 370 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 N 135 - G.HN E 28 G.HN.52
Hydrophobic TM5 M 363 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 M 363 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 V 378 6x36 G.H5 L 353 G.H5.25
Polar TM6 T 375 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 375 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 375 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 124 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL3 F 368 - G.H5 D 337 G.H5.09
Hydrophobic ICL2 I 128 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 I 128 34x51 G.H5 T 340 G.H5.12
Hydrophobic ICL3 F 368 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 P 127 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 127 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM3 V 123 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 V 123 3x53 G.H5 N 347 G.H5.19
Polar ICL2 Q 131 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 Q 131 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 131 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 Q 372 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 Q 372 - G.H5 F 354 G.H5.26
Hydrophobic ICL2 I 128 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 Q 131 34x54 G.S3 L 194 G.S3.01
Hydrophobic ICL3 F 368 - G.H5 F 334 G.H5.06
Hydrophobic TM3 V 124 3x54 G.H5 I 344 G.H5.16
Aromatic ICL3 F 368 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 F 368 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 F 368 - G.S6 Y 320 G.S6.02
Polar ICL2 N 132 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 N 132 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM5 M 363 5x65 G.H5 I 344 G.H5.16
Ionic ICL3 R 367 - G.H5 D 337 G.H5.09
Polar ICL3 R 367 - G.H5 D 337 G.H5.09
Polar ICL3 F 368 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 F 368 - G.H5 K 345 G.H5.17
Hydrophobic ICL2 Q 131 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM6 K 374 6x32 G.H5 L 353 G.H5.25
Polar ICL2 N 132 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 N 132 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 I 128 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM6 K 374 6x32 G.H5 F 354 G.H5.26
Hydrophobic ICL3 K 370 - G.H5 F 354 G.H5.26
Hydrophobic TM3 R 120 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 120 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 I 128 34x51 G.S3 L 194 G.S3.01