Structure information

C3a receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8IA8

SPECIES

Homo sapiens

RESOLUTION

2.860

PREFERRED CHAIN

A

REFERENCE

PUBLICATION DATE

May 24, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
ALA-SER-LYS-LEU-GLY-LEU-ALA-ARG P99 3.29x29 TM3 hydrophobic
ALA-SER-LYS-LEU-GLY-LEU-ALA-ARG I102 3.32x32 TM3 hydrophobic
ALA-SER-LYS-LEU-GLY-LEU-ALA-ARG F164 ECL2 hydrophobic
ALA-SER-LYS-LEU-GLY-LEU-ALA-ARG R340 5.42x43 TM5 polar (charge-assisted hydrogen bond)
ALA-SER-LYS-LEU-GLY-LEU-ALA-ARG Y393 6.51x51 TM6 Van der Waals
ALA-SER-LYS-LEU-GLY-LEU-ALA-ARG Y393 6.51x51 TM6 polar (hydrogen bond with backbone)
ALA-SER-LYS-LEU-GLY-LEU-ALA-ARG F396 6.54x54 TM6 polar (hydrogen bond with backbone)
ALA-SER-LYS-LEU-GLY-LEU-ALA-ARG F396 6.54x54 TM6 Van der Waals
ALA-SER-LYS-LEU-GLY-LEU-ALA-ARG G397 6.55x55 TM6 Van der Waals
ALA-SER-LYS-LEU-GLY-LEU-ALA-ARG D417 7.35x34 TM7 polar (charge-assisted hydrogen bond)
ALA-SER-LYS-LEU-GLY-LEU-ALA-ARG I421 7.39x38 TM7 hydrophobic
ALA-SER-LYS-LEU-GLY-LEU-ALA-ARG I421 7.39x38 TM7 Van der Waals

Ligands

ALA-SER-LYS-LEU-GLY-LEU-ALA-ARG

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Residue Diagrams

G N G P L G L L F T L S L I V M S L I V 1 L H L T L A D L L C C L S L P F S L A H 2 A T L L F V S A F M N L V I I S P I L K 3 A C S I C G C I W V V A F V M C I P V 4 Y C A I M I V S P L L F G V V L R T I T I 5 V V V V A V F L V C W T P Y H I F G V L 6 F P N F C S N A S A L A I C V H D W S 7
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ICL1 M Q R ICL1ECL1 G Q W P Y ECL1ICL2 P I W C Q N H R ICL2ECL2 E I F T T D N H N R C G Y K F G L S S S L D Y P D F Y G D P L E N R S L E N I V Q P P G E M N D R L D P S S F Q T N D H P W T V P T V F Q P Q T F Q R P S A D S L P R G S A R L T S Q N L Y S N V F K P A D V V S P K I P S G F P I E D H E T S P L D N S D A F L S T H L K L F P S A S S N S F Y E S E L P Q G F Q D Y Y N L G Q F T D D D Q ECL2ICL3 G R F A K S Q ICL3ECL3 D P E ECL3N-term M A S F S A E T N S T D L L S Q P W N N-termC-term S I Q G I L E A A F S E E L T R S T H C P S N N V I S E R N S T T V C-term E P P V I L S M V I L S L T F L L G L P G N G L V L W V A G L K T V N T I W F L H L T L A D L L C C L S L P F S L A H L A L Q G R F L C K L I P S I I V L N M F A S V F L L T A I S L D R C L V V F K N V G M A C S I C G C I W V V A F V M C I P V F V Y R V P T P L V A I T I T R L V V G F L L P S V I M I A C Y S F I V F R M Q R S K T F R V A V V V V A V F L V C W T P Y H I F G V L S L L T T P L G K T L M S W D H V C I A L A S A N S C F N P F L Y A L L G K D A R Q F R K K
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Residue Table


GPCRdb(A)
GPCRdb(A)
C3a receptor
TM3
3x29 3.29x29 P99
3x32 3.32x32 I102
TM5
5x43 5.42x43 R340
TM6
6x51 6.51x51 Y393
6x54 6.54x54 F396
6x55 6.55x55 G397
TM7
7x34 7.35x34 D417
7x38 7.39x38 I421