PDB
8IA8
Resolution
2.9 Å
Released
May 24, 2023
Receptor
C3a
Class
A
Species
Homo sapiens
Ligand
Function
E7
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
E7 H81 2.63x63 TM2 Van der Waals
E7 G86 ECL1 Van der Waals
E7 I98 3.28x28 TM3 hydrophobic
E7 P99 3.29x29 TM3 hydrophobic
E7 I102 3.32x32 TM3 hydrophobic
E7 V103 3.33x33 TM3 Van der Waals
E7 M106 3.36x36 TM3 hydrophobic
E7 R161 4.64x65 TM4 Van der Waals
E7 F164 ECL2 hydrophobic
E7 R171 ECL2 Van der Waals
E7 G173 45.51x51 ECL2 Van der Waals
E7 Y174 45.52x52 ECL2 hydrophobic
E7 R340 5.42x43 TM5 polar (charge-charge)
E7 R340 5.42x43 TM5 polar (hydrogen bond)
E7 Y393 6.51x51 TM6 polar (hydrogen bond with backbone)
E7 F396 6.54x54 TM6 Van der Waals
E7 G397 6.55x55 TM6 Van der Waals
E7 D417 7.35x34 TM7 polar (hydrogen bond)
E7 D417 7.35x34 TM7 polar (charge-charge)
E7 C420 7.38x37 TM7 Van der Waals
E7 I421 7.39x38 TM7 Van der Waals

E7

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ICL1 M Q R ICL1ECL1 G Q W P Y ECL1ICL2 P I W C Q N H R ICL2ECL2 E I F T T D N H N R C G Y K F G L S S S L D Y P D F Y G D P L E N R S L E N I V Q P P G E M N D R L D P S S F Q T N D H P W T V P T V F Q P Q T F Q R P S A D S L P R G S A R L T S Q N L Y S N V F K P A D V V S P K I P S G F P I E D H E T S P L D N S D A F L S T H L K L F P S A S S N S F Y E S E L P Q G F Q D Y Y N L G Q F T D D D Q ECL2ICL3 G R F A K S Q ICL3ECL3 D P E ECL3N-term M A S F S A E T N S T D L L S Q P W N N-termC-term S I Q G I L E A A F S E E L T R S T H C P S N N V I S E R N S T T V C-term E P P V I L S M V I L S L T F L L G L P G N G L V L W V A G L K T V N T I W F L H L T L A D L L C C L S L P F S L A H L A L Q G R F L C K L I P S I I V L N M F A S V F L L T A I S L D R C L V V F K N V G M A C S I C G C I W V V A F V M C I P V F V Y R V P T P L V A I T I T R L V V G F L L P S V I M I A C Y S F I V F R M Q R S K T F R V A V V V V A V F L V C W T P Y H I F G V L S L L T T P L G K T L M S W D H V C I A L A S A N S C F N P F L Y A L L G K D A R Q F R K K
Helix box plot — Download: PNG | SVG G N G P L G L L F T L S L I V M S L I V 1 L H L T L A D L L C C L S L P F S L A H 2 A T L L F V S A F M N L V I I S P I L K 3 A C S I C G C I W V V A F V M C I P V 4 Y C A I M I V S P L L F G V V L R T I T I 5 V V V V A V F L V C W T P Y H I F G V L 6 F P N F C S N A S A L A I C V H D W S 7

GPCRdb(A)
GPCRdb(A)
C3a receptor
TM2
2x63 2.63x63 H81
TM3
3x28 3.28x28 I98
3x29 3.29x29 P99
3x32 3.32x32 I102
3x33 3.33x33 V103
3x36 3.36x36 M106
TM4
4x65 4.64x65 R161
ECL2
45x51 45.51x51 G173
45x52 45.52x52 Y174
TM5
5x43 5.42x43 R340
TM6
6x51 6.51x51 Y393
6x54 6.54x54 F396
6x55 6.55x55 G397
TM7
7x34 7.35x34 D417
7x37 7.38x37 C420
7x38 7.39x38 I421