C3a receptor - Go

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Mus musculus

GPCR PREFERRED CHAIN

C

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9KZ8

RESOLUTION

3.3 Å

REFERENCE

10.1073/PNAS.2614459123

PUBLICATION DATE

Nov. 26, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

45 interactions (Click to see)

LIGANDS

EP67 - Agonist

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 123 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 I 123 3x53 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 127 34x50 G.H5 T 340 G.H5.12
Polar TM6 S 364 6x29 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 123 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM4 R 137 4x40 G.HN I 28 G.HN.52
Van-der-waals TM4 R 137 4x40 G.HN I 28 G.HN.52
Hydrophobic H8 G 432 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM7 L 431 7x56 G.H5 L 353 G.H5.25
Hydrophobic ICL3 K 363 - G.H5 Y 354 G.H5.26
Van-der-waals ICL3 K 363 - G.H5 Y 354 G.H5.26
Hydrophobic ICL2 I 128 34x51 G.s2s3 N 194 G.s2s3.02
Hydrophobic TM5 I 352 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 Q 131 34x54 G.H5 I 343 G.H5.15
Hydrophobic ICL1 N 57 - G.H5 G 350 G.H5.22
Polar ICL2 Q 131 34x54 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 Q 131 34x54 G.hns1 K 32 G.hns1.03
Hydrophobic TM3 V 124 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 124 3x54 G.H5 L 348 G.H5.20
Polar TM6 T 368 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 368 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 368 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 I 128 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 I 128 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM6 V 371 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 I 128 34x51 G.H5 T 340 G.H5.12
Hydrophobic ICL2 Q 131 34x54 G.S3 L 195 G.S3.01
Hydrophobic TM4 N 135 4x38 G.HN I 28 G.HN.52
Hydrophobic TM6 S 364 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 S 364 6x29 G.H5 Y 354 G.H5.26
Hydrophobic ICL1 N 57 - G.H5 C 351 G.H5.23
Polar ICL2 N 132 34x55 G.s2s3 N 194 G.s2s3.02
Van-der-waals ICL2 N 132 34x55 G.s2s3 N 194 G.s2s3.02
Hydrophobic ICL2 N 132 34x55 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 N 132 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL3 F 361 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 F 361 - G.H5 I 344 G.H5.16
Hydrophobic TM7 L 431 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 L 431 7x56 G.H5 G 352 G.H5.24
Hydrophobic ICL2 P 127 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 127 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL3 F 361 - G.H5 L 348 G.H5.20
Hydrophobic TM5 M 356 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 M 356 5x65 G.H5 L 348 G.H5.20
Polar ICL2 R 134 34x57 G.H5 N 347 G.H5.19
Hydrophobic ICL2 I 128 34x51 G.S3 L 195 G.S3.01