PDB
9KZ8
Resolution
3.3 Å
Released
Nov. 26, 2025
Receptor
C3a
Class
A
Species
Mus musculus
Ligand
EP67
Function
Agonist
Reference
10.1073/PNAS.2614459123

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Ligand Amino Acid Generic Number Segment Interaction Type
EP67 F77 2.59x59 TM2 hydrophobic
EP67 G86 ECL1 Van der Waals
EP67 G86 ECL1 polar (hydrogen bond with backbone)
EP67 I98 3.28x28 TM3 hydrophobic
EP67 P99 3.29x29 TM3 Van der Waals
EP67 P99 3.29x29 TM3 hydrophobic
EP67 I102 3.32x32 TM3 hydrophobic
EP67 I102 3.32x32 TM3 Van der Waals
EP67 R333 5.42x43 TM5 Van der Waals
EP67 Y386 6.51x51 TM6 Van der Waals
EP67 G390 6.55x55 TM6 Van der Waals
EP67 M407 7.32x31 TM7 Van der Waals
EP67 D410 7.35x34 TM7 polar (charge-assisted hydrogen bond)
EP67 H411 7.36x35 TM7 aromatic (edge-to-face)
EP67 H411 7.36x35 TM7 Van der Waals
EP67 I414 7.39x38 TM7 Van der Waals
EP67 I414 7.39x38 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 M K T ICL1ECL1 G H W P Y ECL1ICL2 P I W C Q N H R ICL2ECL2 D L F I M D N R S I C R Y N F D S S R S Y D Y W D Y V Y K L S L P E S N S T D N S T A Q L T G H M N D R S A P S S V Q A R D Y F W T V T T A L Q S Q P F L T S P E D S F S L D S A N Q Q P H Y G G K P P N V L T A A V P S G F P V E D R K S N T L N A D A F L S A H T E L F P T A S S G H L Y P Y D F Q G D Y V D Q F T Y D N H ECL2ICL3 T N F T K S R ICL3ECL3 D P E ECL3N-term M E S F D A D T N S T D L H S R P L F N-termC-term S I K G I L E A A F S E E L T H S T N C T Q D K A S S K R N N M S T D V C-term Q P Q D I A S M V I L G L T C L L G L L G N G L V L W V A G V K T V N T V W F L H L T L A D F L C C L S L P F S L A H L I L Q G L F L C K L I P S I I I L N M F A S V F L L T A I S L D R C L I V H K N V R T A F A I C G C V W V V A F V M C V P V F V Y R V P T P L M A I T I T R L V V G F L V P F F I M V I C Y S L I V F R M R K N K T F R V A V A V V T V F F I C W T P Y H L V G V L L L I T S S L G E A V M S W D H M S I A L A S A N S C F N P F L Y A L L G K D A R Q F R K K
Helix box plot — Download: PNG | SVG G N G L L G L L C T L G L I V M S A I D 1 L H L T L A D F L C C L S L P F S L A H 2 A T L L F V S A F M N L I I I S P I L K 3 A F A I C G C V W V V A F V M C V P V 4 Y C I V M I F F P V L F G V V L R T I T I 5 V A V V T V F F I C W T P Y H L V G V L 6 F P N F C S N A S A L A I S M H D W S 7

GPCRdb(A)
GPCRdb(A)
C3a receptor
TM2
2x59 2.59x59 F77
TM3
3x28 3.28x28 I98
3x29 3.29x29 P99
3x32 3.32x32 I102
TM5
5x43 5.42x43 R333
TM6
6x51 6.51x51 Y386
6x55 6.55x55 G390
TM7
7x31 7.32x31 M407
7x34 7.35x34 D410
7x35 7.36x35 H411
7x38 7.39x38 I414