GPR55 - G13

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

G12/13

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8ZX4

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

Nov. 13, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

LPI - Agonist

PHYSIOLOGICAL LIGANDS

anandamide, lysophosphatidylinositol, N-palmitoylethanolamine, 2-arachidonoylglycerolphosphoinositol, 2-arachidonoylglycerol



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
E13R16G.H4Q11G.h4s6H17K21Q22L23Q26G.H5GproteinQ-D-Q-V-C6x33Y2x36Q6x30T2x39K-GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.H4G.h4s6G.H5GPCR segments:ICL1TM2ICL3TM6C-term

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null1x571x602x362x392x403x493x503x533x5434x5034x5134x5334x5434x5534x575x655x685x716x306x326x336x366x37G.H5.26G.H5.25G.H5.24G.H5.23G.H5.22G.H5.21G.H5.20G.H5.19G.H5.17G.H5.16G.H5.15G.H5.13G.H5.12G.H5.09G.H5.08G.S6.02G.S6.01G.h4s6.20G.h4s6.12G.h4s6.11G.h4s6.08G.H4.16G.H4.13G.S3.01G.hns1.03G.hns1.02Res. Pos.GPR55 (8ZX4)- (8ZX4)------------------------FFYTSDRAIPLVSHRLRHQACSIFFYTSPLVSHRDRAILRHQACSIQMKQLKILNFVKRLLDRYHQERLRQQP

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.