Refined structure (7T8X) of Go - M2 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 219 from structure (61.9%), 135 from model (38.1%)
Residue sidechains - 208 from structure (58.8%), 146 from model (41.2%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 E G.HN.33 Structure AF2
G.HN 10 R G.HN.34 Structure AF2
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 L G.HN.37 Structure AF2
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 A G.HN.42 Structure AF2
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 E G.HN.44 Structure AF2
G.HN 21 K G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 K G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure AF2
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 I G.HN.52 Structure Structure
G.HN 29 S G.HN.53 Structure AF2
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 K G.hns1.03 Structure Structure
G.S1 33 D G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 Structure Structure
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 D G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 F G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 G H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 D H.HA.03 AF2 AF2
H.HA 66 V H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 P H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 L H.HA.19 AF2 AF2
H.HA 82 A H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 V H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 D H.HA.27 AF2 AF2
H.HA 90 T H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 G H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 E H.hahb.05 AF2 AF2
H.hahb 95 Y H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 K H.hahb.09 AF2 AF2
H.HB 99 E H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 K H.HB.03 AF2 AF2
H.HB 102 A H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 K H.HB.07 AF2 AF2
H.HB 106 M H.HB.08 AF2 AF2
H.HB 107 V H.HB.09 AF2 AF2
H.HB 108 C H.HB.10 AF2 AF2
H.HB 109 D H.HB.11 AF2 AF2
H.HB 110 V H.HB.12 AF2 AF2
H.HB 111 V H.HB.13 AF2 AF2
H.HB 112 S H.HB.14 AF2 AF2
H.hbhc 113 R H.hbhc.01 AF2 AF2
H.hbhc 114 M H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 D H.hbhc.04 AF2 AF2
H.hbhc 117 T H.hbhc.05 AF2 AF2
H.hbhc 118 E H.hbhc.12 AF2 AF2
H.hbhc 119 P H.hbhc.13 AF2 AF2
H.hbhc 120 F H.hbhc.14 AF2 AF2
H.hbhc 121 S H.hbhc.15 AF2 AF2
H.HC 122 A H.HC.01 AF2 AF2
H.HC 123 E H.HC.02 AF2 AF2
H.HC 124 L H.HC.03 AF2 AF2
H.HC 125 L H.HC.04 AF2 AF2
H.HC 126 S H.HC.05 AF2 AF2
H.HC 127 A H.HC.06 AF2 AF2
H.HC 128 M H.HC.07 AF2 AF2
H.HC 129 M H.HC.08 AF2 AF2
H.HC 130 R H.HC.09 AF2 AF2
H.HC 131 L H.HC.10 AF2 AF2
H.HC 132 W H.HC.11 AF2 AF2
H.HC 133 G H.HC.12 AF2 AF2
H.hchd 134 D H.hchd.01 AF2 AF2
H.HD 135 S H.HD.01 AF2 AF2
H.HD 136 G H.HD.02 AF2 AF2
H.HD 137 I H.HD.03 AF2 AF2
H.HD 138 Q H.HD.04 AF2 AF2
H.HD 139 E H.HD.05 AF2 AF2
H.HD 140 C H.HD.06 AF2 AF2
H.HD 141 F H.HD.07 AF2 AF2
H.HD 142 N H.HD.08 AF2 AF2
H.HD 143 R H.HD.09 AF2 AF2
H.HD 144 S H.HD.10 AF2 AF2
H.HD 145 R H.HD.11 AF2 AF2
H.HD 146 E H.HD.12 AF2 AF2
H.hdhe 147 Y H.hdhe.01 AF2 AF2
H.hdhe 148 Q H.hdhe.02 AF2 AF2
H.hdhe 149 L H.hdhe.03 AF2 AF2
H.hdhe 150 N H.hdhe.04 AF2 AF2
H.hdhe 151 D H.hdhe.05 AF2 AF2
H.HE 152 S H.HE.01 AF2 AF2
H.HE 153 A H.HE.02 AF2 AF2
H.HE 154 K H.HE.03 AF2 AF2
H.HE 155 Y H.HE.04 AF2 AF2
H.HE 156 Y H.HE.05 AF2 AF2
H.HE 157 L H.HE.06 AF2 AF2
H.HE 158 D H.HE.07 AF2 AF2
H.HE 159 S H.HE.08 AF2 AF2
H.HE 160 L H.HE.09 AF2 AF2
H.HE 161 D H.HE.10 AF2 AF2
H.HE 162 R H.HE.11 AF2 AF2
H.HE 163 I H.HE.12 AF2 AF2
H.HE 164 G H.HE.13 AF2 AF2
H.hehf 165 A H.hehf.01 AF2 AF2
H.hehf 166 A H.hehf.02 AF2 AF2
H.hehf 167 D H.hehf.03 AF2 AF2
H.hehf 168 Y H.hehf.04 AF2 AF2
H.hehf 169 Q H.hehf.05 AF2 AF2
H.hehf 170 P H.hehf.06 AF2 AF2
H.hehf 171 T H.hehf.07 AF2 AF2
H.HF 172 E H.HF.01 AF2 AF2
H.HF 173 Q H.HF.02 AF2 AF2
H.HF 174 D H.HF.03 AF2 AF2
H.HF 175 I H.HF.04 AF2 AF2
H.HF 176 L H.HF.05 AF2 AF2
H.HF 177 R H.HF.06 AF2 AF2
G.hfs2 178 T G.hfs2.01 AF2 AF2
G.hfs2 179 R G.hfs2.02 AF2 AF2
G.hfs2 180 V G.hfs2.03 AF2 AF2
G.hfs2 181 K G.hfs2.04 AF2 AF2
G.hfs2 182 T G.hfs2.05 Structure Structure
G.hfs2 183 T G.hfs2.06 Structure Structure
G.hfs2 184 G G.hfs2.07 Structure Structure
G.S2 185 I G.S2.01 Structure Structure
G.S2 186 V G.S2.02 Structure Structure
G.S2 187 E G.S2.03 Structure Structure
G.S2 188 T G.S2.04 Structure Structure
G.S2 189 H G.S2.05 Structure Structure
G.S2 190 F G.S2.06 Structure Structure
G.S2 191 T G.S2.07 Structure Structure
G.S2 192 F G.S2.08 Structure Structure
G.s2s3 193 K G.s2s3.01 Structure Structure
G.s2s3 194 N G.s2s3.02 Structure Structure
G.S3 195 L G.S3.01 Structure Structure
G.S3 196 H G.S3.02 Structure Structure
G.S3 197 F G.S3.03 Structure Structure
G.S3 198 R G.S3.04 Structure Structure
G.S3 199 L G.S3.05 Structure Structure
G.S3 200 F G.S3.06 Structure Structure
G.S3 201 D G.S3.07 Structure Structure
G.S3 202 V G.S3.08 Structure Structure
G.s3h2 203 G G.s3h2.01 Structure Structure
G.s3h2 204 G G.s3h2.02 Structure Structure
G.s3h2 205 Q G.s3h2.03 Structure Structure
G.H2 206 R G.H2.01 Structure Structure
G.H2 207 S G.H2.02 Structure Structure
G.H2 208 E G.H2.03 Structure Structure
G.H2 209 R G.H2.04 Structure Structure
G.H2 210 K G.H2.05 Structure Structure
G.H2 211 K G.H2.06 Structure Structure
G.H2 212 W G.H2.07 Structure Structure
G.H2 213 I G.H2.08 Structure Structure
G.H2 214 H G.H2.09 Structure Structure
G.H2 215 C G.H2.10 Structure Structure
G.h2s4 216 F G.h2s4.01 Structure Structure
G.h2s4 217 E G.h2s4.02 Structure Structure
G.h2s4 218 D G.h2s4.03 Structure Structure
G.h2s4 219 V G.h2s4.04 Structure Structure
G.h2s4 220 T G.h2s4.05 Structure Structure
G.S4 221 A G.S4.01 Structure Structure
G.S4 222 I G.S4.02 Structure Structure
G.S4 223 I G.S4.03 Structure Structure
G.S4 224 F G.S4.04 Structure Structure
G.S4 225 C G.S4.05 Structure Structure
G.S4 226 V G.S4.06 Structure Structure
G.S4 227 A G.S4.07 Structure Structure
G.s4h3 228 L G.s4h3.01 Structure Structure
G.s4h3 229 S G.s4h3.02 Structure Structure
G.s4h3 230 G G.s4h3.03 Structure Structure
G.s4h3 231 Y G.s4h3.04 Structure Structure
G.s4h3 232 D G.s4h3.05 Structure Structure
G.s4h3 233 Q G.s4h3.06 Structure Structure
G.s4h3 234 V G.s4h3.07 Structure Structure
G.s4h3 235 L G.s4h3.08 AF2 AF2
G.s4h3 236 H G.s4h3.09 AF2 AF2
G.s4h3 237 E G.s4h3.10 AF2 AF2
G.s4h3 238 D G.s4h3.11 AF2 AF2
G.s4h3 239 E G.s4h3.12 AF2 AF2
G.s4h3 240 T G.s4h3.13 AF2 AF2
G.s4h3 241 T G.s4h3.14 Structure Structure
G.s4h3 242 N G.s4h3.15 Structure Structure
G.H3 243 R G.H3.01 Structure Structure
G.H3 244 M G.H3.02 Structure Structure
G.H3 245 H G.H3.03 Structure Structure
G.H3 246 E G.H3.04 Structure Structure
G.H3 247 S G.H3.05 Structure Structure
G.H3 248 L G.H3.06 Structure Structure
G.H3 249 M G.H3.07 Structure AF2
G.H3 250 L G.H3.08 Structure Structure
G.H3 251 F G.H3.09 Structure Structure
G.H3 252 D G.H3.10 Structure Structure
G.H3 253 S G.H3.11 Structure Structure
G.H3 254 I G.H3.12 Structure Structure
G.H3 255 C G.H3.13 Structure Structure
G.H3 256 N G.H3.14 Structure Structure
G.H3 257 N G.H3.15 Structure Structure
G.H3 258 K G.H3.16 Structure Structure
G.H3 259 F G.H3.17 Structure Structure
G.H3 260 F G.H3.18 Structure Structure
G.h3s5 261 I G.h3s5.01 Structure Structure
G.h3s5 262 D G.h3s5.02 Structure AF2
G.h3s5 263 T G.h3s5.03 Structure Structure
G.S5 264 S G.S5.01 Structure Structure
G.S5 265 I G.S5.02 Structure Structure
G.S5 266 I G.S5.03 Structure Structure
G.S5 267 L G.S5.04 Structure Structure
G.S5 268 F G.S5.05 Structure Structure
G.S5 269 L G.S5.06 Structure Structure
G.S5 270 N G.S5.07 Structure Structure
G.s5hg 271 K G.s5hg.01 Structure Structure
G.HG 272 K G.HG.01 Structure Structure
G.HG 273 D G.HG.02 Structure Structure
G.HG 274 L G.HG.03 Structure Structure
G.HG 275 F G.HG.04 Structure Structure
G.HG 276 G G.HG.05 Structure Structure
G.HG 277 E G.HG.06 Structure Structure
G.HG 278 K G.HG.07 Structure Structure
G.HG 279 I G.HG.08 Structure Structure
G.HG 280 K G.HG.09 Structure Structure
G.HG 281 K G.HG.12 Structure AF2
G.HG 282 S G.HG.13 Structure Structure
G.HG 283 P G.HG.14 Structure Structure
G.HG 284 L G.HG.15 Structure Structure
G.HG 285 T G.HG.16 Structure Structure
G.HG 286 I G.HG.17 Structure Structure
G.hgh4 287 C G.hgh4.01 Structure Structure
G.hgh4 288 F G.hgh4.02 Structure Structure
G.hgh4 289 P G.hgh4.03 Structure Structure
G.hgh4 290 E G.hgh4.04 Structure Structure
G.hgh4 291 Y G.hgh4.05 Structure Structure
G.hgh4 292 T G.hgh4.06 Structure Structure
G.hgh4 293 G G.hgh4.07 Structure Structure
G.hgh4 294 P G.hgh4.08 Structure Structure
G.H4 295 N G.H4.01 Structure Structure
G.H4 296 T G.H4.02 Structure Structure
G.H4 297 Y G.H4.03 Structure Structure
G.H4 298 E G.H4.04 Structure AF2
G.H4 299 D G.H4.05 Structure Structure
G.H4 300 A G.H4.06 Structure Structure
G.H4 301 A G.H4.07 Structure Structure
G.H4 302 A G.H4.08 Structure Structure
G.H4 303 Y G.H4.10 Structure Structure
G.H4 304 I G.H4.11 Structure Structure
G.H4 305 Q G.H4.12 Structure Structure
G.H4 306 A G.H4.13 Structure Structure
G.H4 307 Q G.H4.14 Structure Structure
G.H4 308 F G.H4.15 Structure Structure
G.H4 309 E G.H4.16 Structure Structure
G.H4 310 S G.H4.17 Structure Structure
G.h4s6 311 K G.h4s6.01 Structure Structure
G.h4s6 312 N G.h4s6.02 Structure Structure
G.h4s6 313 R G.h4s6.03 Structure Structure
G.h4s6 314 S G.h4s6.08 Structure Structure
G.h4s6 315 P G.h4s6.09 Structure Structure
G.h4s6 316 N G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 C G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 M G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure Structure
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 N G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 I G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 V G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 I G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 A G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 R G.H5.21 Structure Structure
G.H5 350 G G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 Y G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 275 from structure (83.8%), 53 from model (16.2%)
Residue sidechains - 262 from structure (79.9%), 66 from model (20.1%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 N - AF2 AF2
N-term 3 N - AF2 AF2
N-term 4 S - AF2 AF2
N-term 5 T - AF2 AF2
N-term 6 N - AF2 AF2
N-term 7 S - AF2 AF2
N-term 8 S - AF2 AF2
N-term 9 N - AF2 AF2
N-term 10 N - AF2 AF2
N-term 11 S - AF2 AF2
N-term 12 L - AF2 AF2
N-term 13 A - AF2 AF2
N-term 14 L - AF2 AF2
N-term 15 T - AF2 AF2
N-term 16 S - AF2 AF2
N-term 17 P - AF2 AF2
N-term 18 Y - AF2 AF2
TM1 19 K 1.28x28 AF2 AF2
TM1 20 T 1.29x29 AF2 AF2
TM1 21 F 1.30x30 Structure AF2
TM1 22 E 1.31x31 Structure Structure
TM1 23 V 1.32x32 Structure Structure
TM1 24 V 1.33x33 Structure Structure
TM1 25 F 1.34x34 Structure AF2
TM1 26 I 1.35x35 Structure Structure
TM1 27 V 1.36x36 Structure Structure
TM1 28 L 1.37x37 Structure Structure
TM1 29 V 1.38x38 Structure Structure
TM1 30 A 1.39x39 Structure Structure
TM1 31 G 1.40x40 Structure Structure
TM1 32 S 1.41x41 Structure Structure
TM1 33 L 1.42x42 Structure Structure
TM1 34 S 1.43x43 Structure Structure
TM1 35 L 1.44x44 Structure AF2
TM1 36 V 1.45x45 Structure Structure
TM1 37 T 1.46x46 Structure Structure
TM1 38 I 1.47x47 Structure Structure
TM1 39 I 1.48x48 Structure Structure
TM1 40 G 1.49x49 Structure Structure
TM1 41 N 1.50x50 Structure Structure
TM1 42 I 1.51x51 Structure Structure
TM1 43 L 1.52x52 Structure Structure
TM1 44 V 1.53x53 Structure Structure
TM1 45 M 1.54x54 Structure Structure
TM1 46 V 1.55x55 Structure Structure
TM1 47 S 1.56x56 Structure Structure
TM1 48 I 1.57x57 Structure Structure
TM1 49 K 1.58x58 Structure AF2
TM1 50 V 1.59x59 Structure Structure
TM1 51 N 1.60x60 Structure Structure
ICL1 52 R 12.48x48 Structure Structure
ICL1 53 H 12.49x49 Structure Structure
ICL1 54 L 12.50x50 Structure Structure
ICL1 55 Q 12.51x51 Structure Structure
TM2 56 T 2.37x37 Structure Structure
TM2 57 V 2.38x38 Structure Structure
TM2 58 N 2.39x39 Structure Structure
TM2 59 N 2.40x40 Structure Structure
TM2 60 Y 2.41x41 Structure Structure
TM2 61 F 2.42x42 Structure Structure
TM2 62 L 2.43x43 Structure Structure
TM2 63 F 2.44x44 Structure Structure
TM2 64 S 2.45x45 Structure Structure
TM2 65 L 2.46x46 Structure Structure
TM2 66 A 2.47x47 Structure Structure
TM2 67 C 2.48x48 Structure Structure
TM2 68 A 2.49x49 Structure Structure
TM2 69 D 2.50x50 Structure Structure
TM2 70 L 2.51x51 Structure Structure
TM2 71 I 2.52x52 Structure Structure
TM2 72 I 2.53x53 Structure Structure
TM2 73 G 2.54x54 Structure Structure
TM2 74 V 2.55x55 Structure Structure
TM2 75 F 2.56x551 Structure Structure
TM2 76 S 2.57x56 Structure Structure
TM2 77 M 2.58x57 Structure Structure
TM2 78 N 2.59x58 Structure Structure
TM2 79 L 2.60x59 Structure Structure
TM2 80 Y 2.61x60 Structure Structure
TM2 81 T 2.62x61 Structure Structure
TM2 82 L 2.63x62 Structure Structure
TM2 83 Y 2.64x63 Structure Structure
TM2 84 T 2.65x64 Structure Structure
TM2 85 V 2.66x65 Structure Structure
TM2 86 I 2.67x66 Structure Structure
TM2 87 G 2.68x67 Structure Structure
ECL1 88 Y 23.49x49 Structure Structure
ECL1 89 W 23.50x50 Structure Structure
ECL1 90 P 23.51x51 Structure Structure
ECL1 91 L 23.52x52 Structure AF2
TM3 92 G 3.21x21 Structure Structure
TM3 93 P 3.22x22 Structure Structure
TM3 94 V 3.23x23 Structure Structure
TM3 95 V 3.24x24 Structure Structure
TM3 96 C 3.25x25 Structure Structure
TM3 97 D 3.26x26 Structure Structure
TM3 98 L 3.27x27 Structure Structure
TM3 99 W 3.28x28 Structure Structure
TM3 100 L 3.29x29 Structure Structure
TM3 101 A 3.30x30 Structure Structure
TM3 102 L 3.31x31 Structure Structure
TM3 103 D 3.32x32 Structure Structure
TM3 104 Y 3.33x33 Structure Structure
TM3 105 V 3.34x34 Structure Structure
TM3 106 V 3.35x35 Structure Structure
TM3 107 S 3.36x36 Structure Structure
TM3 108 N 3.37x37 Structure Structure
TM3 109 A 3.38x38 Structure Structure
TM3 110 S 3.39x39 Structure Structure
TM3 111 V 3.40x40 Structure Structure
TM3 112 M 3.41x41 Structure Structure
TM3 113 N 3.42x42 Structure Structure
TM3 114 L 3.43x43 Structure Structure
TM3 115 L 3.44x44 Structure Structure
TM3 116 I 3.45x45 Structure Structure
TM3 117 I 3.46x46 Structure Structure
TM3 118 S 3.47x47 Structure Structure
TM3 119 F 3.48x48 Structure Structure
TM3 120 D 3.49x49 Structure Structure
TM3 121 R 3.50x50 Structure Structure
TM3 122 Y 3.51x51 Structure Structure
TM3 123 F 3.52x52 Structure Structure
TM3 124 C 3.53x53 Structure Structure
TM3 125 V 3.54x54 Structure Structure
TM3 126 T 3.55x55 Structure Structure
TM3 127 K 3.56x56 Structure Structure
ICL2 128 P 34.50x50 Structure Structure
ICL2 129 L 34.51x51 Structure Structure
ICL2 130 T 34.52x52 Structure Structure
ICL2 131 Y 34.53x53 Structure Structure
ICL2 132 P 34.54x54 Structure Structure
ICL2 133 V 34.55x55 Structure Structure
ICL2 134 K 34.56x56 Structure Structure
ICL2 135 R 34.57x57 Structure Structure
TM4 136 T 4.38x38 Structure Structure
TM4 137 T 4.39x39 Structure Structure
TM4 138 K 4.40x40 Structure AF2
TM4 139 M 4.41x41 Structure Structure
TM4 140 A 4.42x42 Structure Structure
TM4 141 G 4.43x43 Structure Structure
TM4 142 M 4.44x44 Structure Structure
TM4 143 M 4.45x45 Structure Structure
TM4 144 I 4.46x46 Structure Structure
TM4 145 A 4.47x47 Structure Structure
TM4 146 A 4.48x48 Structure Structure
TM4 147 A 4.49x49 Structure Structure
TM4 148 W 4.50x50 Structure Structure
TM4 149 V 4.51x51 Structure Structure
TM4 150 L 4.52x52 Structure Structure
TM4 151 S 4.53x53 Structure Structure
TM4 152 F 4.54x54 Structure Structure
TM4 153 I 4.55x55 Structure Structure
TM4 154 L 4.56x56 Structure Structure
TM4 155 W 4.57x57 Structure Structure
TM4 156 A 4.58x58 Structure Structure
TM4 157 P 4.59x59 Structure Structure
TM4 158 A 4.60x60 Structure Structure
TM4 159 I 4.61x61 Structure Structure
TM4 160 L 4.62x62 Structure Structure
TM4 161 F 4.63x63 Structure Structure
TM4 162 W 4.64x64 Structure Structure
TM4 163 Q 4.65x65 Structure AF2
TM4 164 F 4.66x66 Structure Structure
TM4 165 I 4.67x67 Structure AF2
TM4 166 V 4.68x68 Structure Structure
TM4 167 G 4.69x69 Structure Structure
ECL2 168 V - Structure AF2
ECL2 169 R - Structure Structure
ECL2 170 T - Structure Structure
ECL2 171 V - Structure Structure
ECL2 172 E - Structure Structure
ECL2 173 D - Structure AF2
ECL2 174 G - Structure Structure
ECL2 175 E - Structure AF2
ECL2 176 C 45.50x50 Structure Structure
ECL2 177 Y 45.51x51 Structure Structure
ECL2 178 I 45.52x52 Structure Structure
ECL2 179 Q - Structure Structure
ECL2 180 F - Structure Structure
ECL2 181 F - Structure Structure
ECL2 182 S - Structure Structure
TM5 183 N 5.35x36 Structure Structure
TM5 184 A 5.36x37 Structure Structure
TM5 185 A 5.37x38 Structure Structure
TM5 186 V 5.38x39 Structure Structure
TM5 187 T 5.39x40 Structure Structure
TM5 188 F 5.40x41 Structure Structure
TM5 189 G 5.41x42 Structure Structure
TM5 190 T 5.42x43 Structure Structure
TM5 191 A 5.43x44 Structure Structure
TM5 192 I 5.44x45 Structure Structure
TM5 193 A 5.45x46 Structure Structure
TM5 194 A 5.46x461 Structure Structure
TM5 195 F 5.47x47 Structure Structure
TM5 196 Y 5.48x48 Structure Structure
TM5 197 L 5.49x49 Structure Structure
TM5 198 P 5.50x50 Structure Structure
TM5 199 V 5.51x51 Structure Structure
TM5 200 I 5.52x52 Structure Structure
TM5 201 I 5.53x53 Structure Structure
TM5 202 M 5.54x54 Structure Structure
TM5 203 T 5.55x55 Structure Structure
TM5 204 V 5.56x56 Structure Structure
TM5 205 L 5.57x57 Structure Structure
TM5 206 Y 5.58x58 Structure Structure
TM5 207 W 5.59x59 Structure Structure
TM5 208 H 5.60x60 Structure Structure
TM5 209 I 5.61x61 Structure Structure
TM5 210 S 5.62x62 Structure Structure
TM5 211 R 5.63x63 Structure Structure
TM5 212 A 5.64x64 Structure Structure
TM5 213 S 5.65x65 Structure Structure
TM5 214 K 5.66x66 Structure Structure
TM5 215 S 5.67x67 Structure Structure
TM5 216 R 5.68x68 Structure Structure
TM5 217 I 5.69x69 Structure Structure
TM5 218 K 5.70x70 Structure Structure
TM5 219 K 5.71x71 AF2 AF2
TM5 220 D 5.72x72 AF2 AF2
TM5 221 K 5.73x73 AF2 AF2
TM5 222 K 5.74x74 AF2 AF2
TM5 223 E 5.75x75 AF2 AF2
ICL3 224 P - AF2 AF2
ICL3 225 V - AF2 AF2
ICL3 226 A - AF2 AF2
ICL3 227 N - AF2 AF2
ICL3 228 Q - AF2 AF2
ICL3 229 D - AF2 AF2
ICL3 230 P - AF2 AF2
ICL3 369 T - AF2 AF2
ICL3 370 K - AF2 AF2
ICL3 371 Q - AF2 AF2
ICL3 372 P - AF2 AF2
ICL3 373 A - AF2 AF2
ICL3 374 K - AF2 AF2
ICL3 375 K - AF2 AF2
TM6 376 K 6.24x24 AF2 AF2
TM6 377 P 6.25x25 Structure Structure
TM6 378 P 6.26x26 Structure Structure
TM6 379 P 6.27x27 Structure Structure
TM6 380 S 6.28x28 Structure Structure
TM6 381 R 6.29x29 Structure Structure
TM6 382 E 6.30x30 Structure Structure
TM6 383 K 6.31x31 Structure Structure
TM6 384 K 6.32x32 Structure Structure
TM6 385 V 6.33x33 Structure Structure
TM6 386 T 6.34x34 Structure Structure
TM6 387 R 6.35x35 Structure Structure
TM6 388 T 6.36x36 Structure Structure
TM6 389 I 6.37x37 Structure Structure
TM6 390 L 6.38x38 Structure Structure
TM6 391 A 6.39x39 Structure Structure
TM6 392 I 6.40x40 Structure Structure
TM6 393 L 6.41x41 Structure Structure
TM6 394 L 6.42x42 Structure Structure
TM6 395 A 6.43x43 Structure Structure
TM6 396 F 6.44x44 Structure Structure
TM6 397 I 6.45x45 Structure Structure
TM6 398 I 6.46x46 Structure Structure
TM6 399 T 6.47x47 Structure Structure
TM6 400 W 6.48x48 Structure Structure
TM6 401 A 6.49x49 Structure Structure
TM6 402 P 6.50x50 Structure Structure
TM6 403 Y 6.51x51 Structure Structure
TM6 404 N 6.52x52 Structure Structure
TM6 405 V 6.53x53 Structure Structure
TM6 406 M 6.54x54 Structure Structure
TM6 407 V 6.55x55 Structure Structure
TM6 408 L 6.56x56 Structure Structure
TM6 409 I 6.57x57 Structure Structure
TM6 410 N 6.58x58 Structure Structure
TM6 411 T 6.59x59 Structure Structure
TM6 412 F 6.60x60 Structure Structure
TM6 413 C 6.61x61 Structure Structure
ECL3 414 A - Structure Structure
ECL3 415 P - Structure Structure
ECL3 416 C - Structure Structure
ECL3 417 I - Structure Structure
TM7 418 P 7.31x30 Structure Structure
TM7 419 N 7.32x31 Structure Structure
TM7 420 T 7.33x32 Structure Structure
TM7 421 V 7.34x33 Structure Structure
TM7 422 W 7.35x34 Structure Structure
TM7 423 T 7.36x35 Structure Structure
TM7 424 I 7.37x36 Structure Structure
TM7 425 G 7.38x37 Structure Structure
TM7 426 Y 7.39x38 Structure Structure
TM7 427 W 7.40x39 Structure Structure
TM7 428 L 7.41x40 Structure Structure
TM7 429 C 7.42x41 Structure Structure
TM7 430 Y 7.43x42 Structure Structure
TM7 431 I 7.44x43 Structure Structure
TM7 432 N 7.45x45 Structure Structure
TM7 433 S 7.46x46 Structure Structure
TM7 434 T 7.47x47 Structure Structure
TM7 435 I 7.48x48 Structure Structure
TM7 436 N 7.49x49 Structure Structure
TM7 437 P 7.50x50 Structure Structure
TM7 438 A 7.51x51 Structure Structure
TM7 439 C 7.52x52 Structure Structure
TM7 440 Y 7.53x53 Structure Structure
TM7 441 A 7.54x54 Structure Structure
TM7 442 L 7.55x55 Structure Structure
TM7 443 C 7.56x56 Structure Structure
H8 444 N 8.47x47 Structure Structure
H8 445 A 8.48x48 Structure Structure
H8 446 T 8.49x49 Structure Structure
H8 447 F 8.50x50 Structure Structure
H8 448 K 8.51x51 Structure Structure
H8 449 K 8.52x52 Structure AF2
H8 450 T 8.53x53 Structure Structure
H8 451 F 8.54x54 Structure Structure
H8 452 K 8.55x55 Structure AF2
H8 453 H 8.56x56 Structure Structure
H8 454 L 8.57x57 AF2 AF2
H8 455 L 8.58x58 AF2 AF2
H8 456 M 8.59x59 AF2 AF2
C-term 457 C - AF2 AF2
C-term 458 H - AF2 AF2
C-term 459 Y - AF2 AF2
C-term 460 K - AF2 AF2
C-term 461 N - AF2 AF2
C-term 462 I - AF2 AF2
C-term 463 G - AF2 AF2
C-term 464 A - AF2 AF2
C-term 465 T - AF2 AF2
C-term 466 R - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 I 389 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 389 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 388 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 388 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM5 I 217 5x69 G.H5 D 341 G.H5.13
Hydrophobic ICL2 P 128 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 128 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM5 I 217 5x69 G.H5 D 337 G.H5.09
Van-der-waals TM5 I 217 5x69 G.H5 D 337 G.H5.09
Hydrophobic ICL2 L 129 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 129 34x51 G.H5 I 343 G.H5.15
Ionic TM5 K 219 5x71 G.h4s6 E 318 G.h4s6.12
Polar TM5 K 219 5x71 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 K 219 5x71 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 L 129 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 129 34x51 G.S3 L 195 G.S3.01
Hydrophobic TM6 R 381 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 R 381 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM3 C 124 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 C 124 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 K 134 34x56 G.HN I 28 G.HN.52
Hydrophobic TM3 V 125 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 125 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 R 381 6x29 G.H5 L 348 G.H5.20
Van-der-waals TM6 R 381 6x29 G.H5 L 348 G.H5.20
Hydrophobic TM7 C 443 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 C 443 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM3 R 121 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM5 I 217 5x69 G.H5 A 338 G.H5.10
Hydrophobic ICL2 V 133 34x55 G.HN I 28 G.HN.52
Van-der-waals TM6 R 381 6x29 G.H5 A 345 G.H5.17
Polar TM3 C 124 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 C 124 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 C 124 3x53 G.H5 N 347 G.H5.19
Polar TM2 N 58 2x39 G.H5 G 350 G.H5.22
Hydrophobic TM5 S 213 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM5 I 209 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 209 5x61 G.H5 L 353 G.H5.25
Polar TM5 S 215 5x67 G.H5 D 341 G.H5.13
Van-der-waals TM5 S 215 5x67 G.H5 D 341 G.H5.13
Hydrophobic TM6 V 385 6x33 G.H5 L 348 G.H5.20
Polar TM2 N 58 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 N 58 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM6 K 384 6x32 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 384 6x32 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 L 129 34x51 G.hns1 K 32 G.hns1.03
Ionic TM6 R 381 6x29 G.H5 D 341 G.H5.13
Polar TM6 R 381 6x29 G.H5 D 341 G.H5.13
Hydrophobic TM6 R 381 6x29 G.H5 D 341 G.H5.13
Van-der-waals TM6 R 381 6x29 G.H5 D 341 G.H5.13
Polar ICL2 P 128 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 128 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 128 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 T 130 34x52 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 V 133 34x55 G.hns1 A 31 G.hns1.02
Polar TM3 R 121 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 121 3x50 G.H5 C 351 G.H5.23