CysLT2 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9JH5

RESOLUTION

2.8 Å

REFERENCE

10.1038/S41586-025-08792-8

PUBLICATION DATE

April 23, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

39 interactions (Click to see)

LIGANDS

C16:0 ceramide - Agonist pubchem

PHYSIOLOGICAL LIGANDS

LTC4, LTE4, LTD4



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 V 240 6x29 G.h4s6 G 355 G.h4s6.11
Hydrophobic ICL2 V 149 - G.hns1 R 38 G.hns1.02
Hydrophobic TM6 S 241 6x30 G.H5 L 388 G.H5.20
Hydrophobic TM5 L 228 5x65 G.H5 L 388 G.H5.20
Polar H8 E 310 8x48 G.H5 V 394 G.H5.26
Van-der-waals H8 E 310 8x48 G.H5 V 394 G.H5.26
Hydrophobic TM3 V 135 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 V 135 3x49 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 143 - G.H5 I 383 G.H5.15
Hydrophobic TM7 Y 305 7x53 G.H5 N 392 G.H5.24
Van-der-waals TM7 Y 305 7x53 G.H5 N 392 G.H5.24
Polar H8 N 311 8x49 G.H5 E 390 G.H5.22
Hydrophobic H8 N 311 8x49 G.H5 E 390 G.H5.22
Van-der-waals H8 N 311 8x49 G.H5 E 390 G.H5.22
Polar ICL1 S 70 - G.H5 E 390 G.H5.22
Hydrophobic ICL1 S 70 - G.H5 E 390 G.H5.22
Van-der-waals ICL1 S 70 - G.H5 E 390 G.H5.22
Polar H8 F 312 8x50 G.H5 N 392 G.H5.24
Hydrophobic H8 F 312 8x50 G.H5 N 392 G.H5.24
Van-der-waals H8 F 312 8x50 G.H5 N 392 G.H5.24
Hydrophobic TM3 M 140 3x54 G.H5 N 387 G.H5.19
Hydrophobic TM3 M 140 3x54 G.H5 L 393 G.H5.25
Van-der-waals TM3 M 140 3x54 G.H5 L 393 G.H5.25
Hydrophobic TM5 V 227 5x64 G.H5 L 384 G.H5.16
Hydrophobic TM6 K 244 6x33 G.H5 V 394 G.H5.26
Van-der-waals TM6 K 244 6x33 G.H5 V 394 G.H5.26
Hydrophobic TM6 A 245 6x34 G.H5 L 388 G.H5.20
Hydrophobic TM6 A 245 6x34 G.H5 V 394 G.H5.26
Van-der-waals TM6 A 245 6x34 G.H5 V 394 G.H5.26
Hydrophobic TM3 M 140 3x54 G.H5 Y 391 G.H5.23
Ionic H8 E 310 8x48 G.H5 R 389 G.H5.21
Polar H8 E 310 8x48 G.H5 R 389 G.H5.21
Hydrophobic H8 E 310 8x48 G.H5 R 389 G.H5.21
Van-der-waals H8 E 310 8x48 G.H5 R 389 G.H5.21
Hydrophobic TM5 I 224 5x61 G.H5 L 393 G.H5.25
Polar TM6 S 241 6x30 G.H5 Q 385 G.H5.17
Hydrophobic TM6 S 241 6x30 G.H5 Q 385 G.H5.17
Van-der-waals TM6 S 241 6x30 G.H5 Q 385 G.H5.17
Hydrophobic TM2 V 73 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 V 73 2x39 G.H5 Y 391 G.H5.23
Polar H8 N 311 8x49 G.H5 N 392 G.H5.24
Hydrophobic H8 N 311 8x49 G.H5 N 392 G.H5.24
Van-der-waals H8 N 311 8x49 G.H5 N 392 G.H5.24
Hydrophobic TM6 H 242 6x31 G.H5 L 384 G.H5.16
Polar H8 N 311 8x49 G.H5 R 389 G.H5.21
Van-der-waals H8 N 311 8x49 G.H5 R 389 G.H5.21
Hydrophobic ICL2 F 144 - G.S1 L 41 G.S1.02
Hydrophobic ICL2 P 143 - G.H5 K 380 G.H5.12
Polar ICL1 T 71 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL1 T 71 - G.H5 Y 391 G.H5.23
Hydrophobic TM6 S 241 6x30 G.H5 V 394 G.H5.26
Van-der-waals TM6 S 241 6x30 G.H5 V 394 G.H5.26
Hydrophobic TM6 I 249 6x38 G.H5 L 393 G.H5.25
Van-der-waals TM6 I 249 6x38 G.H5 L 393 G.H5.25
Aromatic ICL2 F 144 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 144 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 144 - G.H5 F 376 G.H5.08
Polar TM3 A 139 3x53 G.H5 N 387 G.H5.19
Hydrophobic TM3 A 139 3x53 G.H5 N 387 G.H5.19
Van-der-waals TM3 A 139 3x53 G.H5 N 387 G.H5.19
Polar ICL2 H 148 - G.H5 Y 391 G.H5.23
Hydrophobic ICL2 H 148 - G.H5 Y 391 G.H5.23
Van-der-waals ICL2 H 148 - G.H5 Y 391 G.H5.23
Hydrophobic TM3 A 139 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 139 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM7 A 308 7x56 G.H5 V 394 G.H5.26
Van-der-waals TM7 A 308 7x56 G.H5 V 394 G.H5.26
Hydrophobic ICL2 F 144 - G.H5 K 380 G.H5.12
Hydrophobic TM3 R 136 3x50 G.H5 L 393 G.H5.25
Van-der-waals TM3 R 136 3x50 G.H5 L 393 G.H5.25
Polar TM3 R 136 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 136 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 136 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 M 140 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 F 144 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 144 - G.H5 I 383 G.H5.15
Polar H8 G 309 8x47 G.H5 V 394 G.H5.26
Hydrophobic H8 G 309 8x47 G.H5 V 394 G.H5.26
Van-der-waals H8 G 309 8x47 G.H5 V 394 G.H5.26
Hydrophobic ICL2 F 144 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 144 - G.S3 V 217 G.S3.01
Polar H8 G 309 8x47 G.H5 N 392 G.H5.24
Hydrophobic H8 G 309 8x47 G.H5 N 392 G.H5.24
Van-der-waals H8 G 309 8x47 G.H5 N 392 G.H5.24
Hydrophobic TM6 A 245 6x34 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 245 6x34 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 144 - G.H5 C 379 G.H5.11
Hydrophobic TM2 M 77 2x43 G.H5 N 392 G.H5.24
Van-der-waals TM2 M 77 2x43 G.H5 N 392 G.H5.24