Refined structure (8F7S) of Gi1 - δ receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 221 from structure (62.4%), 133 from model (37.6%)
Residue sidechains - 219 from structure (61.9%), 135 from model (38.1%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 Structure Structure
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 Structure Structure
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 Structure Structure
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 Structure Structure
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure Structure
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure Structure
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 289 from structure (83.8%), 56 from model (16.2%)
Residue sidechains - 282 from structure (81.7%), 63 from model (18.3%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 E - AF2 AF2
N-term 3 P - AF2 AF2
N-term 4 A - AF2 AF2
N-term 5 P - AF2 AF2
N-term 6 S - AF2 AF2
N-term 7 A - AF2 AF2
N-term 8 G - AF2 AF2
N-term 9 A - AF2 AF2
N-term 10 E - AF2 AF2
N-term 11 L - AF2 AF2
N-term 12 Q - AF2 AF2
N-term 13 P - AF2 AF2
N-term 14 P - AF2 AF2
N-term 15 L - AF2 AF2
N-term 16 F - AF2 AF2
N-term 17 A - AF2 AF2
N-term 18 N - AF2 AF2
N-term 19 A - AF2 AF2
N-term 20 S - AF2 AF2
N-term 21 D - AF2 AF2
N-term 22 A - AF2 AF2
N-term 23 Y - AF2 AF2
N-term 24 P - AF2 AF2
N-term 25 S - AF2 AF2
N-term 26 A - AF2 AF2
N-term 27 C - AF2 AF2
N-term 28 P - AF2 AF2
N-term 29 S - AF2 AF2
N-term 30 A - AF2 AF2
N-term 31 G - AF2 AF2
N-term 32 A - AF2 AF2
N-term 33 N - AF2 AF2
N-term 34 A - AF2 AF2
N-term 35 S - AF2 AF2
N-term 36 G - AF2 AF2
N-term 37 P - AF2 AF2
N-term 38 P - AF2 AF2
TM1 39 G 1.22x22 AF2 AF2
TM1 40 A 1.23x23 AF2 AF2
TM1 41 R 1.24x24 AF2 AF2
TM1 42 S 1.25x25 AF2 AF2
TM1 43 A 1.26x26 AF2 AF2
TM1 44 S 1.27x27 AF2 AF2
TM1 45 S 1.28x28 Structure Structure
TM1 46 L 1.29x29 Structure Structure
TM1 47 A 1.30x30 Structure Structure
TM1 48 L 1.31x31 Structure Structure
TM1 49 A 1.32x32 Structure Structure
TM1 50 I 1.33x33 Structure Structure
TM1 51 A 1.34x34 Structure Structure
TM1 52 I 1.35x35 Structure Structure
TM1 53 T 1.36x36 Structure Structure
TM1 54 A 1.37x37 Structure Structure
TM1 55 L 1.38x38 Structure Structure
TM1 56 Y 1.39x39 Structure Structure
TM1 57 S 1.40x40 Structure Structure
TM1 58 A 1.41x41 Structure Structure
TM1 59 V 1.42x42 Structure Structure
TM1 60 C 1.43x43 Structure Structure
TM1 61 A 1.44x44 Structure Structure
TM1 62 V 1.45x45 Structure Structure
TM1 63 G 1.46x46 Structure Structure
TM1 64 L 1.47x47 Structure Structure
TM1 65 L 1.48x48 Structure Structure
TM1 66 G 1.49x49 Structure Structure
TM1 67 N 1.50x50 Structure Structure
TM1 68 V 1.51x51 Structure Structure
TM1 69 L 1.52x52 Structure Structure
TM1 70 V 1.53x53 Structure Structure
TM1 71 M 1.54x54 Structure Structure
TM1 72 F 1.55x55 Structure Structure
TM1 73 G 1.56x56 Structure AF2
TM1 74 I 1.57x57 Structure Structure
TM1 75 V 1.58x58 Structure Structure
TM1 76 R 1.59x59 Structure Structure
TM1 77 Y 1.60x60 Structure Structure
ICL1 78 T 12.48x48 Structure Structure
ICL1 79 K 12.49x49 Structure Structure
ICL1 80 M 12.50x50 Structure Structure
ICL1 81 K 12.51x51 Structure Structure
TM2 82 T 2.37x37 Structure Structure
TM2 83 A 2.38x38 Structure Structure
TM2 84 T 2.39x39 Structure Structure
TM2 85 N 2.40x40 Structure Structure
TM2 86 I 2.41x41 Structure Structure
TM2 87 Y 2.42x42 Structure Structure
TM2 88 I 2.43x43 Structure Structure
TM2 89 F 2.44x44 Structure Structure
TM2 90 N 2.45x45 Structure AF2
TM2 91 L 2.46x46 Structure Structure
TM2 92 A 2.47x47 Structure Structure
TM2 93 L 2.48x48 Structure Structure
TM2 94 A 2.49x49 Structure Structure
TM2 95 D 2.50x50 Structure AF2
TM2 96 A 2.51x51 Structure Structure
TM2 97 L 2.52x52 Structure Structure
TM2 98 A 2.53x53 Structure Structure
TM2 99 T 2.54x54 Structure Structure
TM2 100 S 2.55x55 Structure Structure
TM2 101 T 2.56x56 Structure Structure
TM2 102 L 2.57x57 Structure Structure
TM2 103 P 2.58x58 Structure Structure
TM2 104 F 2.59x59 Structure Structure
TM2 105 Q 2.60x60 Structure Structure
TM2 106 S 2.61x61 Structure Structure
TM2 107 A 2.62x62 Structure Structure
TM2 108 K 2.63x63 Structure Structure
TM2 109 Y 2.64x64 Structure Structure
TM2 110 L 2.65x65 Structure Structure
TM2 111 M 2.66x66 Structure Structure
TM2 112 E 2.67x67 Structure Structure
ECL1 113 T 23.49x49 Structure Structure
ECL1 114 W 23.50x50 Structure Structure
ECL1 115 P 23.51x51 Structure Structure
ECL1 116 F 23.52x52 Structure Structure
TM3 117 G 3.21x21 Structure Structure
TM3 118 E 3.22x22 Structure Structure
TM3 119 L 3.23x23 Structure Structure
TM3 120 L 3.24x24 Structure Structure
TM3 121 C 3.25x25 Structure Structure
TM3 122 K 3.26x26 Structure Structure
TM3 123 A 3.27x27 Structure Structure
TM3 124 V 3.28x28 Structure Structure
TM3 125 L 3.29x29 Structure Structure
TM3 126 S 3.30x30 Structure Structure
TM3 127 I 3.31x31 Structure Structure
TM3 128 D 3.32x32 Structure Structure
TM3 129 Y 3.33x33 Structure Structure
TM3 130 Y 3.34x34 Structure Structure
TM3 131 N 3.35x35 Structure AF2
TM3 132 M 3.36x36 Structure Structure
TM3 133 F 3.37x37 Structure Structure
TM3 134 T 3.38x38 Structure Structure
TM3 135 S 3.39x39 Structure Structure
TM3 136 I 3.40x40 Structure Structure
TM3 137 F 3.41x41 Structure Structure
TM3 138 T 3.42x42 Structure Structure
TM3 139 L 3.43x43 Structure Structure
TM3 140 T 3.44x44 Structure Structure
TM3 141 M 3.45x45 Structure Structure
TM3 142 M 3.46x46 Structure Structure
TM3 143 S 3.47x47 Structure AF2
TM3 144 V 3.48x48 Structure Structure
TM3 145 D 3.49x49 Structure Structure
TM3 146 R 3.50x50 Structure Structure
TM3 147 Y 3.51x51 Structure Structure
TM3 148 I 3.52x52 Structure Structure
TM3 149 A 3.53x53 Structure Structure
TM3 150 V 3.54x54 Structure Structure
TM3 151 C 3.55x55 Structure Structure
TM3 152 H 3.56x56 Structure Structure
ICL2 153 P 34.50x50 Structure Structure
ICL2 154 V 34.51x51 Structure Structure
ICL2 155 K 34.52x52 Structure Structure
ICL2 156 A 34.53x53 Structure Structure
ICL2 157 L 34.54x54 Structure Structure
ICL2 158 D 34.55x55 Structure Structure
ICL2 159 F 34.56x56 Structure Structure
ICL2 160 R 34.57x57 Structure Structure
TM4 161 T 4.38x38 Structure Structure
TM4 162 P 4.39x39 Structure Structure
TM4 163 A 4.40x40 Structure Structure
TM4 164 K 4.41x41 Structure Structure
TM4 165 A 4.42x42 Structure Structure
TM4 166 K 4.43x43 Structure Structure
TM4 167 L 4.44x44 Structure Structure
TM4 168 I 4.45x45 Structure Structure
TM4 169 N 4.46x46 Structure Structure
TM4 170 I 4.47x47 Structure Structure
TM4 171 C 4.48x48 Structure Structure
TM4 172 I 4.49x49 Structure Structure
TM4 173 W 4.50x50 Structure Structure
TM4 174 V 4.51x51 Structure Structure
TM4 175 L 4.52x52 Structure Structure
TM4 176 A 4.53x53 Structure Structure
TM4 177 S 4.54x54 Structure Structure
TM4 178 G 4.55x55 Structure Structure
TM4 179 V 4.56x56 Structure Structure
TM4 180 G 4.57x57 Structure Structure
TM4 181 V 4.58x58 Structure Structure
TM4 182 P 4.59x59 Structure Structure
TM4 183 I 4.60x60 Structure Structure
TM4 184 M 4.61x61 Structure Structure
TM4 185 V 4.62x62 Structure Structure
TM4 186 M 4.63x63 Structure Structure
TM4 187 A 4.64x64 Structure Structure
ECL2 188 V - Structure Structure
ECL2 189 T - Structure Structure
ECL2 190 R - Structure Structure
ECL2 191 P - Structure Structure
ECL2 192 R - Structure Structure
ECL2 193 D - Structure Structure
ECL2 194 G - Structure Structure
ECL2 195 A - Structure Structure
ECL2 196 V - Structure Structure
ECL2 197 V - Structure Structure
ECL2 198 C 45.50x50 Structure Structure
ECL2 199 M 45.51x51 Structure Structure
ECL2 200 L 45.52x52 Structure Structure
ECL2 201 Q - Structure Structure
ECL2 202 F - Structure Structure
ECL2 203 P - Structure Structure
ECL2 204 S - Structure Structure
TM5 205 P 5.30x31 Structure Structure
TM5 206 S 5.31x32 Structure Structure
TM5 207 W 5.32x33 Structure Structure
TM5 208 Y 5.33x34 Structure Structure
TM5 209 W 5.34x35 Structure Structure
TM5 210 D 5.35x36 Structure Structure
TM5 211 T 5.36x37 Structure Structure
TM5 212 V 5.37x38 Structure Structure
TM5 213 T 5.38x39 Structure Structure
TM5 214 K 5.39x40 Structure Structure
TM5 215 I 5.40x41 Structure Structure
TM5 216 C 5.41x42 Structure Structure
TM5 217 V 5.42x43 Structure Structure
TM5 218 F 5.43x44 Structure Structure
TM5 219 L 5.44x45 Structure Structure
TM5 220 F 5.45x46 Structure Structure
TM5 221 A 5.46x461 Structure Structure
TM5 222 F 5.47x47 Structure Structure
TM5 223 V 5.48x48 Structure Structure
TM5 224 V 5.49x49 Structure Structure
TM5 225 P 5.50x50 Structure Structure
TM5 226 I 5.51x51 Structure Structure
TM5 227 L 5.52x52 Structure Structure
TM5 228 I 5.53x53 Structure Structure
TM5 229 I 5.54x54 Structure Structure
TM5 230 T 5.55x55 Structure Structure
TM5 231 V 5.56x56 Structure Structure
TM5 232 C 5.57x57 Structure Structure
TM5 233 Y 5.58x58 Structure Structure
TM5 234 G 5.59x59 Structure Structure
TM5 235 L 5.60x60 Structure Structure
TM5 236 M 5.61x61 Structure Structure
TM5 237 L 5.62x62 Structure Structure
TM5 238 L 5.63x63 Structure Structure
TM5 239 R 5.64x64 Structure Structure
TM5 240 L 5.65x65 Structure Structure
TM5 241 R 5.66x66 Structure Structure
TM5 242 S 5.67x67 Structure Structure
TM5 243 V 5.68x68 Structure Structure
ICL3 244 R - Structure Structure
ICL3 245 L - Structure Structure
ICL3 246 L - Structure Structure
ICL3 247 S - Structure Structure
ICL3 248 G - Structure Structure
TM6 249 S 6.23x23 Structure Structure
TM6 250 K 6.24x24 Structure Structure
TM6 251 E 6.25x25 Structure Structure
TM6 252 K 6.26x26 Structure Structure
TM6 253 D 6.27x27 Structure Structure
TM6 254 R 6.28x28 Structure Structure
TM6 255 S 6.29x29 Structure Structure
TM6 256 L 6.30x30 Structure Structure
TM6 257 R 6.31x31 Structure Structure
TM6 258 R 6.32x32 Structure Structure
TM6 259 I 6.33x33 Structure Structure
TM6 260 T 6.34x34 Structure Structure
TM6 261 R 6.35x35 Structure Structure
TM6 262 M 6.36x36 Structure Structure
TM6 263 V 6.37x37 Structure Structure
TM6 264 L 6.38x38 Structure Structure
TM6 265 V 6.39x39 Structure Structure
TM6 266 V 6.40x40 Structure Structure
TM6 267 V 6.41x41 Structure Structure
TM6 268 G 6.42x42 Structure AF2
TM6 269 A 6.43x43 Structure Structure
TM6 270 F 6.44x44 Structure Structure
TM6 271 V 6.45x45 Structure Structure
TM6 272 V 6.46x46 Structure Structure
TM6 273 C 6.47x47 Structure Structure
TM6 274 W 6.48x48 Structure Structure
TM6 275 A 6.49x49 Structure Structure
TM6 276 P 6.50x50 Structure Structure
TM6 277 I 6.51x51 Structure Structure
TM6 278 H 6.52x52 Structure Structure
TM6 279 I 6.53x53 Structure Structure
TM6 280 F 6.54x54 Structure Structure
TM6 281 V 6.55x55 Structure Structure
TM6 282 I 6.56x56 Structure Structure
TM6 283 V 6.57x57 Structure Structure
TM6 284 W 6.58x58 Structure Structure
TM6 285 T 6.59x59 Structure Structure
TM6 286 L 6.60x60 Structure Structure
TM6 287 V 6.61x61 Structure Structure
ECL3 288 D - Structure Structure
ECL3 289 I - Structure Structure
ECL3 290 D - Structure Structure
ECL3 291 R - Structure Structure
ECL3 292 R - Structure Structure
TM7 293 D 7.28x27 Structure Structure
TM7 294 P 7.29x28 Structure Structure
TM7 295 L 7.30x29 Structure Structure
TM7 296 V 7.31x30 Structure Structure
TM7 297 V 7.32x31 Structure Structure
TM7 298 A 7.33x32 Structure Structure
TM7 299 A 7.34x33 Structure Structure
TM7 300 L 7.35x34 Structure Structure
TM7 301 H 7.36x35 Structure Structure
TM7 302 L 7.37x36 Structure Structure
TM7 303 C 7.38x37 Structure Structure
TM7 304 I 7.39x38 Structure Structure
TM7 305 A 7.40x39 Structure Structure
TM7 306 L 7.41x40 Structure Structure
TM7 307 G 7.42x41 Structure Structure
TM7 308 Y 7.43x42 Structure Structure
TM7 309 A 7.44x43 Structure AF2
TM7 310 N 7.45x45 Structure Structure
TM7 311 S 7.46x46 Structure Structure
TM7 312 S 7.47x47 Structure Structure
TM7 313 L 7.48x48 Structure Structure
TM7 314 N 7.49x49 Structure Structure
TM7 315 P 7.50x50 Structure Structure
TM7 316 V 7.51x51 Structure Structure
TM7 317 L 7.52x52 Structure Structure
TM7 318 Y 7.53x53 Structure Structure
TM7 319 A 7.54x54 Structure Structure
TM7 320 F 7.55x55 Structure Structure
TM7 321 L 7.56x56 Structure Structure
H8 322 D 8.47x47 Structure Structure
H8 323 E 8.48x48 Structure Structure
H8 324 N 8.49x49 Structure Structure
H8 325 F 8.50x50 Structure Structure
H8 326 K 8.51x51 Structure Structure
H8 327 R 8.52x52 Structure Structure
H8 328 C 8.53x53 Structure Structure
H8 329 F 8.54x54 Structure Structure
H8 330 R 8.55x55 Structure Structure
H8 331 Q 8.56x56 Structure Structure
H8 332 L 8.57x57 Structure Structure
H8 333 C 8.58x58 Structure Structure
H8 334 R 8.59x59 AF2 AF2
H8 335 K 8.60x60 AF2 AF2
C-term 336 P - AF2 AF2
C-term 337 C - AF2 AF2
C-term 338 G - AF2 AF2
C-term 339 R - AF2 AF2
C-term 340 P - AF2 AF2
C-term 341 D - AF2 AF2
C-term 342 P - AF2 AF2
C-term 343 S - AF2 AF2
C-term 344 S - AF2 AF2
C-term 345 F - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 A 149 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM5 L 240 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL3 R 244 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 R 244 - G.S6 Y 320 G.S6.02
Polar H8 E 323 8x48 G.H5 G 352 G.H5.24
Hydrophobic H8 E 323 8x48 G.H5 G 352 G.H5.24
Van-der-waals H8 E 323 8x48 G.H5 G 352 G.H5.24
Hydrophobic ICL2 L 157 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 157 34x54 G.S3 L 194 G.S3.01
Hydrophobic ICL3 L 246 - G.H5 L 348 G.H5.20
Ionic TM6 K 252 6x26 G.h4s6 E 318 G.h4s6.12
Polar TM6 K 252 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 K 252 6x26 G.h4s6 E 318 G.h4s6.12
Polar TM3 A 149 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 149 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 149 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 R 239 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 239 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM3 V 150 3x54 G.H5 I 344 G.H5.16
Hydrophobic H8 D 322 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 D 322 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL2 P 153 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL2 P 153 34x50 G.H5 T 340 G.H5.12
Van-der-waals ICL2 P 153 34x50 G.H5 T 340 G.H5.12
Hydrophobic ICL2 V 154 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM5 M 236 5x61 G.H5 L 348 G.H5.20
Hydrophobic ICL3 L 245 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 L 245 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 M 262 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM5 V 243 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 V 243 5x68 G.H5 D 341 G.H5.13
Hydrophobic ICL2 R 160 34x57 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 153 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 153 34x50 G.H5 I 343 G.H5.15
Hydrophobic H8 E 323 8x48 G.H5 F 354 G.H5.26
Polar H8 N 324 8x49 G.H5 D 350 G.H5.22
Polar ICL2 R 160 34x57 G.H5 N 347 G.H5.19
Hydrophobic TM6 V 263 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM5 M 236 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 M 236 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 146 3x50 G.H5 L 353 G.H5.25
Polar ICL3 R 244 - G.S6 I 319 G.S6.01
Hydrophobic TM6 I 259 6x33 G.H5 L 353 G.H5.25
Hydrophobic C-term F 345 - G.H3 W 258 G.H3.17
Van-der-waals C-term F 345 - G.H3 W 258 G.H3.17
Ionic ICL2 R 160 34x57 G.H5 D 350 G.H5.22
Polar ICL2 R 160 34x57 G.H5 D 350 G.H5.22
Hydrophobic ICL3 L 245 - G.H5 F 354 G.H5.26
Hydrophobic ICL2 V 154 34x51 G.H5 F 336 G.H5.08
Hydrophobic C-term F 345 - G.h2s4 E 216 G.h2s4.02
Van-der-waals C-term F 345 - G.h2s4 E 216 G.h2s4.02
Polar TM2 T 82 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 82 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 82 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM5 V 243 5x68 G.H5 I 344 G.H5.16
Ionic ICL2 D 158 34x55 G.hns1 R 32 G.hns1.03
Polar ICL2 D 158 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 D 158 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 R 244 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 S 255 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 S 255 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM3 V 150 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 I 259 6x33 G.H5 F 354 G.H5.26
Polar ICL3 R 244 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 L 245 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 L 245 - G.H5 K 345 G.H5.17
Hydrophobic ICL2 V 154 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM3 R 146 3x50 G.H5 C 351 G.H5.23