ghrelin receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7NA7

RESOLUTION

2.7 Å

REFERENCE

10.1038/S41467-021-26735-5

PUBLICATION DATE

Dec. 15, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

72 interactions (Click to see)

LIGANDS

Ghrelin-27 - Agonist

PHYSIOLOGICAL LIGANDS

[des-Gln14]ghrelin, ghrelin



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 239 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 148 34x50 G.H5 T 340 G.H5.12
Hydrophobic ICL2 L 149 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 L 149 34x51 G.H5 F 336 G.H5.08
Polar ICL2 K 152 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 L 149 34x51 G.H5 T 340 G.H5.12
Ionic TM5 R 242 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 242 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM6 Q 260 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 Q 260 6x32 G.H5 F 354 G.H5.26
Hydrophobic ICL2 L 149 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM3 A 144 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 141 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 141 3x50 G.H5 L 353 G.H5.25
Ionic TM5 R 243 5x69 G.H5 D 341 G.H5.13
Polar TM5 R 243 5x69 G.H5 D 341 G.H5.13
Hydrophobic ICL2 K 152 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM6 L 265 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 265 6x37 G.H5 L 353 G.H5.25
Hydrophobic H8 S 327 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM4 T 156 4x38 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 T 156 4x38 G.hns1 R 32 G.hns1.03
Ionic H8 K 329 8x49 G.H5 D 350 G.H5.22
Polar H8 K 329 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 K 329 8x49 G.H5 D 350 G.H5.22
Polar TM6 T 261 6x33 G.H5 F 354 G.H5.26
Hydrophobic ICL2 K 152 34x54 G.hns1 R 32 G.hns1.03
Polar TM3 A 144 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 144 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 144 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM4 T 156 4x38 G.HN E 28 G.HN.52
Hydrophobic TM3 I 145 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM5 R 242 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 242 5x68 G.H5 I 344 G.H5.16
Polar TM3 R 141 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 141 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 141 3x50 G.H5 C 351 G.H5.23
Polar TM6 T 261 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 261 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 261 6x33 G.H5 L 353 G.H5.25
Polar ICL2 V 153 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 V 153 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 T 261 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 148 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM6 N 257 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 M 264 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 145 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 145 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 L 149 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 149 34x51 G.H5 I 343 G.H5.15
Polar TM4 G 158 4x40 G.HN E 28 G.HN.52
Hydrophobic ICL2 P 148 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 148 34x50 G.H5 I 344 G.H5.16
Polar TM2 T 78 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 78 2x39 G.H5 C 351 G.H5.23