ADGRD1 - Gs

GPCR CLASS (FAMILY)

Class B2 (Adhesion)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Bos taurus

PDB CODE

8X9T

RESOLUTION

2.8 Å

REFERENCE

10.1016/J.CELL.2025.01.006

PUBLICATION DATE

Feb. 12, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

39 interactions (Click to see)

LIGANDS

AP503 - Agonist pubchem

PHYSIOLOGICAL LIGANDS

dihydrotestosterone



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Van-der-waals TM6 V 764 6x44 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 665 - G.S3 V 217 G.S3.01
Polar TM2 R 601 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 601 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM2 R 601 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM3 V 661 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 V 661 3x58 G.H5 L 388 G.H5.20
Hydrophobic TM5 I 741 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM6 V 764 6x44 G.H5 L 393 G.H5.25
Van-der-waals TM6 V 764 6x44 G.H5 L 393 G.H5.25
Polar TM3 E 653 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 665 - G.S3 F 219 G.S3.03
Hydrophobic TM5 V 734 5x57 G.H5 L 388 G.H5.20
Aromatic ICL2 F 665 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 665 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 665 - G.H5 F 376 G.H5.08
Polar TM3 L 657 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 657 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 657 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 V 664 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 V 664 - G.H5 R 380 G.H5.12
Hydrophobic TM5 I 741 5x64 G.H5 L 394 G.H5.26
Van-der-waals TM5 I 741 5x64 G.H5 L 394 G.H5.26
Hydrophobic ICL2 V 664 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 V 664 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 V 664 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 V 664 - G.H5 Q 384 G.H5.16
Hydrophobic TM5 V 734 5x57 G.H5 L 393 G.H5.25
Aromatic TM2 R 601 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 601 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 601 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM6 L 757 6x37 G.H5 L 394 G.H5.26
Van-der-waals TM6 L 757 6x37 G.H5 L 394 G.H5.26
Hydrophobic ICL2 F 665 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 665 - G.H5 R 380 G.H5.12
Hydrophobic TM3 L 657 3x54 G.H5 L 393 G.H5.25
Van-der-waals ICL2 K 663 - G.H5 R 380 G.H5.12
Hydrophobic TM5 I 738 5x61 G.H5 L 388 G.H5.20
Hydrophobic TM6 I 768 6x48 G.H5 Y 391 G.H5.23
Polar ICL2 S 667 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 S 667 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 S 667 - G.H5 H 387 G.H5.19
Polar TM3 M 660 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 M 660 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 M 660 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM2 H 605 2x50 G.H5 Y 391 G.H5.23
Aromatic ICL2 F 665 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 665 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 665 - G.S1 H 41 G.S1.02
Hydrophobic TM5 V 737 5x60 G.H5 L 388 G.H5.20
Hydrophobic TM6 A 761 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 761 6x41 G.H5 L 393 G.H5.25
Hydrophobic ICL4 S 811 - G.H5 E 392 G.H5.24
Hydrophobic TM3 M 660 3x57 G.H5 Y 391 G.H5.23
Van-der-waals TM3 M 660 3x57 G.H5 Y 391 G.H5.23
Hydrophobic ICL4 N 810 - G.H5 E 392 G.H5.24
Van-der-waals ICL4 N 810 - G.H5 E 392 G.H5.24
Hydrophobic TM5 V 737 5x60 G.H5 Q 384 G.H5.16
Van-der-waals TM5 V 737 5x60 G.H5 Q 384 G.H5.16
Hydrophobic TM5 I 738 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM6 L 765 6x45 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 665 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 665 - G.H5 I 383 G.H5.15
Hydrophobic H8 E 812 8x49 G.H5 Q 390 G.H5.22
Hydrophobic TM5 I 741 5x64 G.H5 L 388 G.H5.20
Van-der-waals TM5 I 741 5x64 G.H5 L 388 G.H5.20
Polar TM3 V 661 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 V 661 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 661 3x58 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 F 665 - G.H5 C 379 G.H5.11