Refined structure (7Y1F) of Gi1 - κ receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 217 from structure (61.3%), 137 from model (38.7%)
Residue sidechains - 196 from structure (55.4%), 158 from model (44.6%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 AF2 AF2
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure AF2
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure AF2
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure AF2
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure AF2
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 Structure AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure AF2
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure AF2
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure Structure
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure AF2
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure AF2
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure AF2
G.s4h3 233 V G.s4h3.07 Structure AF2
G.s4h3 234 L G.s4h3.08 AF2 AF2
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 AF2 AF2
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure Structure
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure AF2
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure AF2
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure AF2
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure AF2
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure AF2
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure AF2
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure AF2
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure Structure
G.s6h5 327 T G.s6h5.04 Structure AF2
G.s6h5 328 D G.s6h5.05 Structure AF2
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure AF2
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 198 from structure (55.6%), 158 from model (44.4%)
Residue sidechains - 14 from structure (3.9%), 342 from model (96.1%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 D - AF2 AF2
N-term 3 S - AF2 AF2
N-term 4 P - AF2 AF2
N-term 5 I - AF2 AF2
N-term 6 Q - AF2 AF2
N-term 7 I - AF2 AF2
N-term 8 F - AF2 AF2
N-term 9 R - AF2 AF2
N-term 10 G - AF2 AF2
N-term 11 E - AF2 AF2
N-term 12 P - AF2 AF2
N-term 13 G - AF2 AF2
N-term 14 P - AF2 AF2
N-term 15 T - AF2 AF2
N-term 16 C - AF2 AF2
N-term 17 A - AF2 AF2
N-term 18 P - AF2 AF2
N-term 19 S - AF2 AF2
N-term 20 A - AF2 AF2
N-term 21 C - AF2 AF2
N-term 22 L - AF2 AF2
N-term 23 P - AF2 AF2
N-term 24 P - AF2 AF2
N-term 25 N - AF2 AF2
N-term 26 S - AF2 AF2
N-term 27 S - AF2 AF2
N-term 28 A - AF2 AF2
N-term 29 W - AF2 AF2
N-term 30 F - AF2 AF2
N-term 31 P - AF2 AF2
N-term 32 G - AF2 AF2
N-term 33 W - AF2 AF2
N-term 34 A - AF2 AF2
N-term 35 E - AF2 AF2
N-term 36 P - AF2 AF2
N-term 37 D - AF2 AF2
N-term 38 S - AF2 AF2
N-term 39 N - AF2 AF2
N-term 40 G - AF2 AF2
N-term 41 S - AF2 AF2
N-term 42 A - AF2 AF2
N-term 43 G - AF2 AF2
N-term 44 S - AF2 AF2
N-term 45 E - AF2 AF2
N-term 46 D - AF2 AF2
N-term 47 A - AF2 AF2
N-term 48 Q - AF2 AF2
N-term 49 L - AF2 AF2
N-term 50 E - AF2 AF2
N-term 51 P - AF2 AF2
N-term 52 A - AF2 AF2
N-term 53 H - AF2 AF2
N-term 54 I - AF2 AF2
N-term 55 S - AF2 AF2
N-term 56 P - AF2 AF2
TM1 57 A 1.30x30 AF2 AF2
TM1 58 I 1.31x31 AF2 AF2
TM1 59 P 1.32x32 AF2 AF2
TM1 60 V 1.33x33 AF2 AF2
TM1 61 I 1.34x34 AF2 AF2
TM1 62 I 1.35x35 AF2 AF2
TM1 63 T 1.36x36 AF2 AF2
TM1 64 A 1.37x37 AF2 AF2
TM1 65 V 1.38x38 AF2 AF2
TM1 66 Y 1.39x39 AF2 AF2
TM1 67 S 1.40x40 AF2 AF2
TM1 68 V 1.41x41 AF2 AF2
TM1 69 V 1.42x42 AF2 AF2
TM1 70 F 1.43x43 AF2 AF2
TM1 71 V 1.44x44 AF2 AF2
TM1 72 V 1.45x45 AF2 AF2
TM1 73 G 1.46x46 AF2 AF2
TM1 74 L 1.47x47 AF2 AF2
TM1 75 V 1.48x48 AF2 AF2
TM1 76 G 1.49x49 AF2 AF2
TM1 77 N 1.50x50 AF2 AF2
TM1 78 S 1.51x51 AF2 AF2
TM1 79 L 1.52x52 AF2 AF2
TM1 80 V 1.53x53 AF2 AF2
TM1 81 M 1.54x54 AF2 AF2
TM1 82 F 1.55x55 AF2 AF2
TM1 83 V 1.56x56 AF2 AF2
TM1 84 I 1.57x57 AF2 AF2
TM1 85 I 1.58x58 AF2 AF2
TM1 86 R 1.59x59 AF2 AF2
TM1 87 Y 1.60x60 AF2 AF2
ICL1 88 T 12.48x48 AF2 AF2
ICL1 89 K 12.49x49 AF2 AF2
ICL1 90 M 12.50x50 AF2 AF2
ICL1 91 K 12.51x51 AF2 AF2
TM2 92 T 2.37x37 AF2 AF2
TM2 93 A 2.38x38 AF2 AF2
TM2 94 T 2.39x39 AF2 AF2
TM2 95 N 2.40x40 AF2 AF2
TM2 96 I 2.41x41 AF2 AF2
TM2 97 Y 2.42x42 AF2 AF2
TM2 98 I 2.43x43 AF2 AF2
TM2 99 F 2.44x44 AF2 AF2
TM2 100 N 2.45x45 AF2 AF2
TM2 101 L 2.46x46 AF2 AF2
TM2 102 A 2.47x47 AF2 AF2
TM2 103 L 2.48x48 AF2 AF2
TM2 104 A 2.49x49 AF2 AF2
TM2 105 D 2.50x50 AF2 AF2
TM2 106 A 2.51x51 AF2 AF2
TM2 107 L 2.52x52 AF2 AF2
TM2 108 V 2.53x53 AF2 AF2
TM2 109 T 2.54x54 AF2 AF2
TM2 110 T 2.55x55 AF2 AF2
TM2 111 T 2.56x56 AF2 AF2
TM2 112 M 2.57x57 AF2 AF2
TM2 113 P 2.58x58 AF2 AF2
TM2 114 F 2.59x59 AF2 AF2
TM2 115 Q 2.60x60 AF2 AF2
TM2 116 S 2.61x61 AF2 AF2
TM2 117 T 2.62x62 AF2 AF2
TM2 118 V 2.63x63 AF2 AF2
TM2 119 Y 2.64x64 AF2 AF2
TM2 120 L 2.65x65 AF2 AF2
TM2 121 M 2.66x66 AF2 AF2
TM2 122 N 2.67x67 AF2 AF2
ECL1 123 S 23.49x49 AF2 AF2
ECL1 124 W 23.50x50 AF2 AF2
ECL1 125 P 23.51x51 AF2 AF2
ECL1 126 F 23.52x52 AF2 AF2
TM3 127 G 3.21x21 AF2 AF2
TM3 128 D 3.22x22 AF2 AF2
TM3 129 V 3.23x23 AF2 AF2
TM3 130 L 3.24x24 AF2 AF2
TM3 131 C 3.25x25 AF2 AF2
TM3 132 K 3.26x26 AF2 AF2
TM3 133 I 3.27x27 AF2 AF2
TM3 134 V 3.28x28 AF2 AF2
TM3 135 I 3.29x29 AF2 AF2
TM3 136 S 3.30x30 AF2 AF2
TM3 137 I 3.31x31 AF2 AF2
TM3 138 D 3.32x32 AF2 AF2
TM3 139 Y 3.33x33 AF2 AF2
TM3 140 Y 3.34x34 AF2 AF2
TM3 141 N 3.35x35 AF2 AF2
TM3 142 M 3.36x36 AF2 AF2
TM3 143 F 3.37x37 AF2 AF2
TM3 144 T 3.38x38 AF2 AF2
TM3 145 S 3.39x39 AF2 AF2
TM3 146 I 3.40x40 AF2 AF2
TM3 147 F 3.41x41 AF2 AF2
TM3 148 T 3.42x42 AF2 AF2
TM3 149 L 3.43x43 AF2 AF2
TM3 150 T 3.44x44 AF2 AF2
TM3 151 M 3.45x45 AF2 AF2
TM3 152 M 3.46x46 AF2 AF2
TM3 153 S 3.47x47 AF2 AF2
TM3 154 V 3.48x48 AF2 AF2
TM3 155 D 3.49x49 AF2 AF2
TM3 156 R 3.50x50 AF2 AF2
TM3 157 Y 3.51x51 AF2 AF2
TM3 158 I 3.52x52 AF2 AF2
TM3 159 A 3.53x53 Structure Structure
TM3 160 V 3.54x54 Structure AF2
TM3 161 C 3.55x55 Structure AF2
TM3 162 H 3.56x56 Structure AF2
ICL2 163 P 34.50x50 Structure AF2
ICL2 164 V 34.51x51 Structure AF2
ICL2 165 K 34.52x52 Structure AF2
ICL2 166 A 34.53x53 Structure Structure
ICL2 167 L 34.54x54 Structure AF2
ICL2 168 D 34.55x55 Structure AF2
ICL2 169 F 34.56x56 Structure AF2
ICL2 170 R 34.57x57 Structure AF2
TM4 171 T 4.38x38 Structure AF2
TM4 172 P 4.39x39 Structure AF2
TM4 173 L 4.40x40 Structure AF2
TM4 174 K 4.41x41 Structure AF2
TM4 175 A 4.42x42 Structure AF2
TM4 176 K 4.43x43 Structure AF2
TM4 177 I 4.44x44 Structure AF2
TM4 178 I 4.45x45 Structure AF2
TM4 179 N 4.46x46 Structure Structure
TM4 180 I 4.47x47 Structure AF2
TM4 181 C 4.48x48 Structure AF2
TM4 182 I 4.49x49 Structure AF2
TM4 183 W 4.50x50 Structure AF2
TM4 184 L 4.51x51 Structure AF2
TM4 185 L 4.52x52 Structure AF2
TM4 186 S 4.53x53 Structure AF2
TM4 187 S 4.54x54 Structure AF2
TM4 188 S 4.55x55 Structure AF2
TM4 189 V 4.56x56 Structure AF2
TM4 190 G 4.57x57 Structure AF2
TM4 191 I 4.58x58 Structure AF2
TM4 192 S 4.59x59 Structure AF2
TM4 193 A 4.60x60 Structure AF2
TM4 194 I 4.61x61 Structure AF2
TM4 195 V 4.62x62 Structure AF2
TM4 196 L 4.63x63 Structure AF2
TM4 197 G 4.64x64 Structure AF2
ECL2 198 G - Structure AF2
ECL2 199 T - Structure AF2
ECL2 200 K - Structure AF2
ECL2 201 V - Structure AF2
ECL2 202 R - Structure AF2
ECL2 203 E - Structure AF2
ECL2 204 D - Structure AF2
ECL2 205 V - Structure AF2
ECL2 206 D - Structure AF2
ECL2 207 V - Structure AF2
ECL2 208 I - Structure AF2
ECL2 209 E - Structure AF2
ECL2 210 C 45.50x50 Structure AF2
ECL2 211 S 45.51x51 Structure AF2
ECL2 212 L 45.52x52 Structure AF2
ECL2 213 Q - Structure AF2
ECL2 214 F - Structure AF2
ECL2 215 P - Structure Structure
ECL2 216 D - Structure AF2
ECL2 217 D - Structure AF2
TM5 218 D 5.30x31 Structure AF2
TM5 219 Y 5.31x32 Structure AF2
TM5 220 S 5.32x33 Structure AF2
TM5 221 W 5.33x34 Structure AF2
TM5 222 W 5.34x35 Structure AF2
TM5 223 D 5.35x36 Structure AF2
TM5 224 L 5.36x37 Structure AF2
TM5 225 F 5.37x38 Structure AF2
TM5 226 M 5.38x39 Structure AF2
TM5 227 K 5.39x40 Structure AF2
TM5 228 I 5.40x41 Structure AF2
TM5 229 C 5.41x42 Structure AF2
TM5 230 V 5.42x43 Structure AF2
TM5 231 F 5.43x44 Structure AF2
TM5 232 I 5.44x45 Structure AF2
TM5 233 F 5.45x46 Structure AF2
TM5 234 A 5.46x461 Structure AF2
TM5 235 F 5.47x47 Structure AF2
TM5 236 V 5.48x48 Structure Structure
TM5 237 I 5.49x49 Structure AF2
TM5 238 P 5.50x50 Structure AF2
TM5 239 V 5.51x51 Structure AF2
TM5 240 L 5.52x52 Structure AF2
TM5 241 I 5.53x53 Structure AF2
TM5 242 I 5.54x54 Structure AF2
TM5 243 I 5.55x55 Structure AF2
TM5 244 V 5.56x56 Structure AF2
TM5 245 C 5.57x57 Structure AF2
TM5 246 Y 5.58x58 Structure AF2
TM5 247 T 5.59x59 Structure AF2
TM5 248 L 5.60x60 Structure AF2
TM5 249 M 5.61x61 Structure AF2
TM5 250 I 5.62x62 Structure AF2
TM5 251 L 5.63x63 Structure Structure
TM5 252 R 5.64x64 Structure AF2
TM5 253 L 5.65x65 Structure AF2
TM5 254 K 5.66x66 Structure AF2
TM5 255 S 5.67x67 Structure Structure
TM5 256 V 5.68x68 Structure Structure
ICL3 257 R - Structure AF2
ICL3 258 L - Structure AF2
ICL3 259 L - Structure AF2
ICL3 260 S - Structure AF2
ICL3 261 G - Structure AF2
TM6 262 S 6.23x23 Structure AF2
TM6 263 R 6.24x24 Structure AF2
TM6 264 E 6.25x25 Structure AF2
TM6 265 K 6.26x26 Structure AF2
TM6 266 D 6.27x27 Structure AF2
TM6 267 R 6.28x28 Structure AF2
TM6 268 N 6.29x29 Structure AF2
TM6 269 L 6.30x30 Structure Structure
TM6 270 R 6.31x31 Structure AF2
TM6 271 R 6.32x32 Structure AF2
TM6 272 I 6.33x33 Structure AF2
TM6 273 T 6.34x34 Structure Structure
TM6 274 R 6.35x35 Structure AF2
TM6 275 L 6.36x36 Structure Structure
TM6 276 V 6.37x37 Structure AF2
TM6 277 L 6.38x38 Structure AF2
TM6 278 V 6.39x39 Structure AF2
TM6 279 V 6.40x40 Structure AF2
TM6 280 V 6.41x41 Structure AF2
TM6 281 A 6.42x42 Structure AF2
TM6 282 V 6.43x43 Structure AF2
TM6 283 F 6.44x44 Structure AF2
TM6 284 V 6.45x45 Structure AF2
TM6 285 V 6.46x46 Structure AF2
TM6 286 C 6.47x47 Structure AF2
TM6 287 W 6.48x48 Structure AF2
TM6 288 T 6.49x49 Structure AF2
TM6 289 P 6.50x50 Structure AF2
TM6 290 I 6.51x51 Structure AF2
TM6 291 H 6.52x52 Structure AF2
TM6 292 I 6.53x53 Structure AF2
TM6 293 F 6.54x54 Structure AF2
TM6 294 I 6.55x55 Structure AF2
TM6 295 L 6.56x56 Structure AF2
TM6 296 V 6.57x57 Structure AF2
TM6 297 E 6.58x58 Structure AF2
TM6 298 A 6.59x59 Structure AF2
TM6 299 L 6.60x60 Structure AF2
TM6 300 G 6.61x61 Structure Structure
ECL3 301 S - Structure AF2
ECL3 302 T - Structure AF2
ECL3 303 S - Structure AF2
ECL3 304 H - Structure AF2
TM7 305 S 7.28x27 Structure AF2
TM7 306 T 7.29x28 Structure AF2
TM7 307 A 7.30x29 Structure AF2
TM7 308 A 7.31x30 Structure AF2
TM7 309 L 7.32x31 Structure AF2
TM7 310 S 7.33x32 Structure AF2
TM7 311 S 7.34x33 Structure AF2
TM7 312 Y 7.35x34 Structure AF2
TM7 313 Y 7.36x35 Structure AF2
TM7 314 F 7.37x36 Structure AF2
TM7 315 C 7.38x37 Structure AF2
TM7 316 I 7.39x38 Structure AF2
TM7 317 A 7.40x39 Structure AF2
TM7 318 L 7.41x40 Structure AF2
TM7 319 G 7.42x41 Structure AF2
TM7 320 Y 7.43x42 Structure AF2
TM7 321 T 7.44x43 Structure AF2
TM7 322 N 7.45x45 Structure AF2
TM7 323 S 7.46x46 Structure AF2
TM7 324 S 7.47x47 Structure AF2
TM7 325 L 7.48x48 Structure AF2
TM7 326 N 7.49x49 Structure AF2
TM7 327 P 7.50x50 Structure AF2
TM7 328 I 7.51x51 Structure AF2
TM7 329 L 7.52x52 Structure AF2
TM7 330 Y 7.53x53 Structure AF2
TM7 331 A 7.54x54 Structure AF2
TM7 332 F 7.55x55 Structure AF2
TM7 333 L 7.56x56 Structure AF2
H8 334 D 8.47x47 Structure AF2
H8 335 E 8.48x48 Structure AF2
H8 336 N 8.49x49 Structure AF2
H8 337 F 8.50x50 Structure Structure
H8 338 K 8.51x51 Structure AF2
H8 339 R 8.52x52 Structure AF2
H8 340 C 8.53x53 Structure AF2
H8 341 F 8.54x54 Structure AF2
H8 342 R 8.55x55 Structure AF2
H8 343 D 8.56x56 Structure AF2
H8 344 F 8.57x57 Structure AF2
H8 345 C 8.58x58 Structure AF2
H8 346 F 8.59x59 Structure AF2
C-term 347 P - Structure AF2
C-term 348 L - Structure AF2
C-term 349 K - Structure AF2
C-term 350 M - Structure AF2
C-term 351 R - Structure AF2
C-term 352 M - Structure AF2
C-term 353 E - Structure AF2
C-term 354 R - Structure Structure
C-term 355 Q - Structure AF2
C-term 356 S - Structure AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic TM6 K 265 6x26 G.H5 D 341 G.H5.13
Polar TM6 K 265 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM6 S 262 6x23 G.H5 I 344 G.H5.16
Hydrophobic ICL3 L 258 - G.H5 C 351 G.H5.23
Van-der-waals ICL3 L 258 - G.H5 C 351 G.H5.23
Hydrophobic TM6 K 265 6x26 G.H5 I 344 G.H5.16
Van-der-waals TM6 K 265 6x26 G.H5 I 344 G.H5.16
Hydrophobic TM6 L 269 6x30 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 D 266 6x27 G.S3 L 194 G.S3.01
Hydrophobic ICL3 G 261 - G.H5 L 348 G.H5.20
Van-der-waals ICL3 G 261 - G.H5 L 348 G.H5.20
Hydrophobic C-term Q 355 - G.H5 K 349 G.H5.21
Van-der-waals C-term Q 355 - G.H5 K 349 G.H5.21
Hydrophobic TM6 N 268 6x29 G.H5 L 348 G.H5.20
Van-der-waals TM6 N 268 6x29 G.H5 L 348 G.H5.20
Van-der-waals TM6 D 266 6x27 G.s2s3 K 192 G.s2s3.01
Polar ICL3 R 257 - G.H5 C 351 G.H5.23
Hydrophobic ICL3 R 257 - G.H5 C 351 G.H5.23
Van-der-waals ICL3 R 257 - G.H5 C 351 G.H5.23
Hydrophobic TM6 I 272 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM6 K 265 6x26 G.H5 T 340 G.H5.12
Van-der-waals TM6 K 265 6x26 G.H5 T 340 G.H5.12
Hydrophobic ICL3 L 258 - G.H5 G 352 G.H5.24
Van-der-waals ICL3 L 258 - G.H5 G 352 G.H5.24
Hydrophobic TM6 K 265 6x26 G.H5 L 348 G.H5.20
Van-der-waals TM6 K 265 6x26 G.H5 L 348 G.H5.20
Polar TM4 L 196 4x63 G.H5 D 350 G.H5.22
Hydrophobic TM4 L 196 4x63 G.H5 D 350 G.H5.22
Van-der-waals TM4 L 196 4x63 G.H5 D 350 G.H5.22
Hydrophobic TM6 K 265 6x26 G.H5 I 343 G.H5.15
Hydrophobic TM4 L 196 4x63 G.H5 C 351 G.H5.23
Van-der-waals TM4 L 196 4x63 G.H5 C 351 G.H5.23
Hydrophobic TM6 D 266 6x27 G.H5 F 336 G.H5.08
Van-der-waals TM6 D 266 6x27 G.H5 F 336 G.H5.08