D1 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9LLH

RESOLUTION

2.7 Å

REFERENCE

PUBLICATION DATE

March 4, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

124 interactions (Click to see)

LIGANDS

dopamine - Agonist pubchem gtoplig chembl_ligand drugbank drug_central pubchem ,

Agonist-positive allosteric GEM targeting TM5/6/7 - Ago-PAM

PHYSIOLOGICAL LIGANDS

5-hydroxytryptamine, noradrenaline, dopamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 A 124 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 124 3x53 G.H5 Y 391 G.H5.23
Aromatic ICL2 F 129 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 129 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 129 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 Y 131 34x53 G.H5 H 387 G.H5.19
Polar ICL2 R 133 34x55 G.s2s3 K 216 G.s2s3.02
Hydrophobic ICL2 R 133 34x55 G.s2s3 K 216 G.s2s3.02
Hydrophobic ICL2 F 129 34x51 G.H5 I 383 G.H5.15
Polar TM5 Q 224 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 A 234 5x78 G.H4 L 346 G.H4.16
Hydrophobic ICL2 E 132 34x54 G.hns1 A 39 G.hns1.03
Aromatic TM3 R 121 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 121 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 121 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 128 34x50 G.H5 Q 384 G.H5.16
Hydrophobic TM5 A 238 5x82 G.H4 D 343 G.H4.13
Van-der-waals TM5 A 238 5x82 G.H4 D 343 G.H4.13
Hydrophobic TM6 V 270 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 V 270 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM5 L 231 5x75 G.H4 R 342 G.H4.12
Van-der-waals TM5 L 231 5x75 G.H4 R 342 G.H4.12
Ionic ICL2 E 132 34x54 G.hns1 R 38 G.hns1.02
Polar ICL2 E 132 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 E 132 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 E 132 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic TM3 I 125 3x54 G.H5 L 393 G.H5.25
Polar TM3 D 120 3x49 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 128 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 128 34x50 G.H5 I 383 G.H5.15
Polar ICL2 M 135 34x57 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 M 135 34x57 G.hns1 R 38 G.hns1.02
Hydrophobic TM5 A 235 5x79 G.H4 R 347 G.H4.17
Hydrophobic TM6 L 274 6x37 G.H5 L 393 G.H5.25
Ionic H8 R 338 8x51 G.H5 E 392 G.H5.24
Polar H8 R 338 8x51 G.H5 E 392 G.H5.24
Van-der-waals ICL2 R 133 34x55 G.S3 V 217 G.S3.01
Polar TM3 I 125 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 125 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 125 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM5 A 234 5x78 G.H4 D 343 G.H4.13
Hydrophobic TM4 T 136 4x38 G.hns1 R 38 G.hns1.02
Van-der-waals TM4 T 136 4x38 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 F 129 34x51 G.H5 C 379 G.H5.11
Polar TM5 H 237 5x81 G.hgh4 T 319 G.hgh4.09
Van-der-waals TM5 H 237 5x81 G.hgh4 T 319 G.hgh4.09
Polar TM5 C 241 5x85 G.hgh4 T 319 G.hgh4.09
Hydrophobic TM6 T 273 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM5 I 225 5x69 G.H5 L 394 G.H5.26
Hydrophobic TM5 I 228 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 228 5x72 G.H5 R 385 G.H5.17
Aromatic ICL2 F 129 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 129 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 129 34x51 G.H5 F 376 G.H5.08
Polar TM5 C 241 5x85 G.hgh4 R 317 G.hgh4.07
Hydrophobic TM5 C 241 5x85 G.hgh4 R 317 G.hgh4.07
Van-der-waals TM5 C 241 5x85 G.hgh4 R 317 G.hgh4.07
Hydrophobic TM5 Q 224 5x68 G.H5 L 388 G.H5.20
Polar ICL2 R 133 34x55 G.HN Q 35 G.HN.52
Hydrophobic TM5 I 228 5x72 G.S6 Y 360 G.S6.02
Van-der-waals TM5 I 228 5x72 G.S6 Y 360 G.S6.02
Hydrophobic TM5 A 238 5x82 G.H4 R 347 G.H4.17
Hydrophobic TM5 H 237 5x81 G.hgh4 Y 318 G.hgh4.08
Polar TM5 Q 242 5x86 G.hgh4 R 317 G.hgh4.07
Hydrophobic TM5 Q 242 5x86 G.hgh4 R 317 G.hgh4.07
Van-der-waals TM5 Q 242 5x86 G.hgh4 R 317 G.hgh4.07
Hydrophobic ICL2 F 129 34x51 G.S3 F 219 G.S3.03
Hydrophobic TM5 I 228 5x72 G.H5 L 394 G.H5.26
Hydrophobic TM4 T 136 4x38 G.HN Q 35 G.HN.52
Hydrophobic ICL2 F 129 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 129 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM3 I 125 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 125 3x54 G.H5 L 388 G.H5.20
Polar TM6 K 269 6x32 G.H5 L 394 G.H5.26
Hydrophobic ICL2 F 129 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 129 34x51 G.S3 V 217 G.S3.01
Polar TM5 Q 224 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 Q 224 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 Q 224 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 A 238 5x82 G.hgh4 Y 318 G.hgh4.08
Polar ICL2 R 133 34x55 G.hns1 R 38 G.hns1.02
Polar TM5 H 237 5x81 G.hgh4 P 321 G.hgh4.11
Hydrophobic TM5 H 237 5x81 G.hgh4 P 321 G.hgh4.11
Ionic ICL2 E 132 34x54 G.H5 H 387 G.H5.19
Hydrophobic TM3 I 125 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM5 A 235 5x79 G.H4 L 346 G.H4.16
Polar TM5 Q 224 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 Q 224 5x68 G.H5 Q 384 G.H5.16
Polar TM3 A 124 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 124 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 124 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 128 34x50 G.H5 R 380 G.H5.12
Hydrophobic TM5 L 231 5x75 G.H4 L 346 G.H4.16
Van-der-waals TM5 L 231 5x75 G.H4 L 346 G.H4.16
Hydrophobic TM5 I 220 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 I 220 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 C 241 5x85 G.hgh4 Y 318 G.hgh4.08
Hydrophobic TM5 Q 242 5x86 G.hgh4 E 314 G.hgh4.04
Van-der-waals TM5 Q 242 5x86 G.hgh4 E 314 G.hgh4.04
Ionic TM5 R 233 5x77 G.hgh4 D 323 G.hgh4.13
Polar TM5 R 233 5x77 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM5 R 233 5x77 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM5 I 217 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 I 217 5x61 G.H5 L 393 G.H5.25
Polar TM6 T 273 6x36 G.H5 E 392 G.H5.24
Polar TM3 S 126 3x55 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 P 128 34x50 G.H5 H 387 G.H5.19
Hydrophobic TM5 A 221 5x65 G.H5 L 388 G.H5.20
Ionic TM5 R 227 5x71 G.H5 D 381 G.H5.13
Polar TM5 R 227 5x71 G.H5 D 381 G.H5.13
Van-der-waals TM5 R 227 5x71 G.H5 D 381 G.H5.13
Polar TM3 S 126 3x55 G.H5 R 380 G.H5.12
Van-der-waals TM3 S 126 3x55 G.H5 R 380 G.H5.12
Hydrophobic TM3 I 125 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 I 125 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 R 133 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic TM5 A 235 5x79 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM5 A 235 5x79 G.h4s6 T 350 G.h4s6.03