PDB
9LLH
Resolution
2.7 Å
Released
March 4, 2026
Receptor
D1
Class
A
Species
Homo sapiens
Ligands
dopamine
Agonist-positive allosteric GEM targeting TM5/6/7
Function
Agonist
Ago-PAM
Reference
—
dopamine Agonist-positive allosteric GEM targeting TM5/6/7

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Ligand Amino Acid Generic Number Segment Interaction Type
dopamine D103 3.32x32 TM3 polar (charge-assisted hydrogen bond)
dopamine I104 3.33x33 TM3 Van der Waals
dopamine I104 3.33x33 TM3 hydrophobic
dopamine S107 3.36x36 TM3 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 I196 5.40x41 TM5 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 I196 5.40x41 TM5 Van der Waals
dopamine S198 5.42x43 TM5 polar (hydrogen bond)
dopamine S198 5.42x43 TM5 polar (hydrogen bond with backbone)
dopamine S198 5.42x43 TM5 Van der Waals
dopamine S202 5.46x461 TM5 polar (hydrogen bond)
dopamine S202 5.46x461 TM5 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 Y204 5.48x48 TM5 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 Y204 5.48x48 TM5 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 I211 5.55x55 TM5 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 I211 5.55x55 TM5 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 F264 6.27x27 TM6 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 F264 6.27x27 TM6 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 T268 6.31x31 TM6 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 L271 6.34x34 TM6 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 L271 6.34x34 TM6 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 K272 6.35x35 TM6 polar (charge-assisted hydrogen bond)
Agonist-positive allosteric GEM targeting TM5/6/7 T273 6.36x36 TM6 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 S275 6.38x38 TM6 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 V276 6.39x39 TM6 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 V276 6.39x39 TM6 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 M278 6.41x41 TM6 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 M278 6.41x41 TM6 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 G279 6.42x42 TM6 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 V280 6.43x43 TM6 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 V280 6.43x43 TM6 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 V282 6.45x45 TM6 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 V282 6.45x45 TM6 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 C283 6.46x46 TM6 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 C283 6.46x46 TM6 polar (hydrogen bond with backbone)
Agonist-positive allosteric GEM targeting TM5/6/7 L286 6.49x49 TM6 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 L286 6.49x49 TM6 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 P287 6.50x50 TM6 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 P287 6.50x50 TM6 Van der Waals
dopamine F288 6.51x51 TM6 aromatic (edge-to-face)
dopamine F288 6.51x51 TM6 Van der Waals
dopamine F289 6.52x52 TM6 Van der Waals
dopamine F289 6.52x52 TM6 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 I290 6.53x53 TM6 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 I290 6.53x53 TM6 Van der Waals
dopamine N292 6.55x55 TM6 polar (hydrogen bond)
dopamine N292 6.55x55 TM6 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 C293 6.56x56 TM6 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 C293 6.56x56 TM6 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 I294 6.57x57 TM6 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 I294 6.57x57 TM6 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 F297 6.60x60 TM6 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 F297 6.60x60 TM6 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 C298 6.61x61 TM6 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 C307 ECL3 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 C307 ECL3 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 I308 ECL3 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 I308 ECL3 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 F316 7.38x37 TM7 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 F316 7.38x37 TM7 aromatic (edge-to-face)
Agonist-positive allosteric GEM targeting TM5/6/7 F319 7.41x40 TM7 aromatic (face-to-edge)
Agonist-positive allosteric GEM targeting TM5/6/7 F319 7.41x40 TM7 Van der Waals
dopamine W321 7.43x42 TM7 polar (hydrogen bond)
Agonist-positive allosteric GEM targeting TM5/6/7 I329 7.51x51 TM7 polar (hydrogen bond with backbone)
Agonist-positive allosteric GEM targeting TM5/6/7 I329 7.51x51 TM7 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 I330 7.52x52 TM7 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 F333 7.55x55 TM7 polar (hydrogen bond with backbone)
Agonist-positive allosteric GEM targeting TM5/6/7 F333 7.55x55 TM7 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 N334 8.47x47 H8 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 R338 8.51x51 H8 polar (charge-assisted hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 R H L R S ICL1ECL1 F W P F ECL1ICL2 P F R Y E R K M ICL2ECL2 W H K A K P T S P S D G N A T S L A E T I D N C D S S L ECL2ICL3 T T T G N G K P V E C S Q P E S S F ICL3ECL3 G S G E T Q P F C I ECL3N-term M R T L N T S A M D G T G L V V E R D F N-termC-term C Y R L C P A T N N A I E T V S I N N N G A A M F S S H H E P R G S I S K E C N L V Y L I P H A V G S S E D L K K E E A A G I A R P L E K L S P A L S V I L D Y D T D V S L E K I Q P I T Q N G Q H P T C-term S V R I L T A C F L S L L I L S T L L G N T L V C A A V I R F K V T N F F V I S L A V S D L L V A V L V M P W K A V A E I A G G S F C N I W V A F D I M C S T A S I L N L C V I S V D R Y W A I S S T P K A A F I L I S V A W T L S V L I S F I P V Q L S S R T Y A I S S S V I S F Y I P V A I M I V T Y T R I Y R I A Q K Q I R R I A A L E R A A V H A K N C Q K M S F K R E T K V L K T L S V I M G V F V C C W L P F F I L N C I L P F C D S N T F D V F V W F G W A N S S L N P I I Y A F N A D F S T F R K A L L G
Helix box plot — Download: PNG | SVG T N G L L T S L I L L S L F C A T L I R 1 I S L A V S D L L V A L V V M P W K A V A 2 V C L N L I S A T S C M I D F A V W I N 3 A F I L I S V A W T L S V L I S F I P V 4 Y T V I M I A V P I Y F S I V S S S I A Y 5 S V I M G V F V C C W L P F F I L N C I 6 I P N L S S N A W G F W V F V D F T N 7

GPCRdb(A)
GPCRdb(A)
D1 receptor
TM3
3x32 3.32x32 D103
3x33 3.33x33 I104
3x36 3.36x36 S107
TM5
5x41 5.40x41 I196
5x43 5.42x43 S198
5x461 5.46x461 S202
5x48 5.48x48 Y204
5x55 5.55x55 I211
TM6
6x27 6.27x27 F264
6x31 6.31x31 T268
6x34 6.34x34 L271
6x35 6.35x35 K272
6x36 6.36x36 T273
6x38 6.38x38 S275
6x39 6.39x39 V276
6x41 6.41x41 M278
6x42 6.42x42 G279
6x43 6.43x43 V280
6x45 6.45x45 V282
6x46 6.46x46 C283
6x49 6.49x49 L286
6x50 6.50x50 P287
6x51 6.51x51 F288
6x52 6.52x52 F289
6x53 6.53x53 I290
6x55 6.55x55 N292
6x56 6.56x56 C293
6x57 6.57x57 I294
6x60 6.60x60 F297
6x61 6.61x61 C298
TM7
7x37 7.38x37 F316
7x40 7.41x40 F319
7x42 7.43x42 W321
7x51 7.51x51 I329
7x52 7.52x52 I330
7x55 7.55x55 F333
H8
8x47 8.47x47 N334
8x51 8.51x51 R338