Refined structure (6E3Y) of Gs - calcitonin receptor-like receptor

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 188 from structure (47.7%), 206 from model (52.3%)
Residue sidechains - 175 from structure (44.4%), 219 from model (55.6%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 L G.HN.10 AF2 AF2
G.HN 5 G G.HN.11 AF2 AF2
G.HN 6 N G.HN.22 AF2 AF2
G.HN 7 S G.HN.23 AF2 AF2
G.HN 8 K G.HN.24 AF2 AF2
G.HN 9 T G.HN.26 AF2 AF2
G.HN 10 E G.HN.27 AF2 AF2
G.HN 11 D G.HN.28 AF2 AF2
G.HN 12 Q G.HN.29 AF2 AF2
G.HN 13 R G.HN.30 AF2 AF2
G.HN 14 N G.HN.31 AF2 AF2
G.HN 15 E G.HN.32 Structure Structure
G.HN 16 E G.HN.33 Structure Structure
G.HN 17 K G.HN.34 Structure Structure
G.HN 18 A G.HN.35 Structure Structure
G.HN 19 Q G.HN.36 Structure Structure
G.HN 20 R G.HN.37 Structure Structure
G.HN 21 E G.HN.38 Structure Structure
G.HN 22 A G.HN.39 Structure Structure
G.HN 23 N G.HN.40 Structure Structure
G.HN 24 K G.HN.41 Structure Structure
G.HN 25 K G.HN.42 Structure Structure
G.HN 26 I G.HN.43 Structure Structure
G.HN 27 E G.HN.44 Structure Structure
G.HN 28 K G.HN.45 Structure Structure
G.HN 29 Q G.HN.46 Structure Structure
G.HN 30 L G.HN.47 Structure Structure
G.HN 31 Q G.HN.48 Structure Structure
G.HN 32 K G.HN.49 Structure Structure
G.HN 33 D G.HN.50 Structure Structure
G.HN 34 K G.HN.51 Structure Structure
G.HN 35 Q G.HN.52 Structure Structure
G.HN 36 V G.HN.53 Structure Structure
G.hns1 37 Y G.hns1.01 Structure Structure
G.hns1 38 R G.hns1.02 Structure Structure
G.hns1 39 A G.hns1.03 Structure Structure
G.S1 40 T G.S1.01 Structure Structure
G.S1 41 H G.S1.02 Structure Structure
G.S1 42 R G.S1.03 Structure Structure
G.S1 43 L G.S1.04 Structure Structure
G.S1 44 L G.S1.05 Structure Structure
G.S1 45 L G.S1.06 Structure Structure
G.S1 46 L G.S1.07 Structure Structure
G.s1h1 47 G G.s1h1.01 Structure Structure
G.s1h1 48 A G.s1h1.02 AF2 AF2
G.s1h1 49 G G.s1h1.03 AF2 AF2
G.s1h1 50 E G.s1h1.04 AF2 AF2
G.s1h1 51 S G.s1h1.05 AF2 AF2
G.s1h1 52 G G.s1h1.06 AF2 AF2
G.H1 53 K G.H1.01 AF2 AF2
G.H1 54 S G.H1.02 AF2 AF2
G.H1 55 T G.H1.03 AF2 AF2
G.H1 56 I G.H1.04 AF2 AF2
G.H1 57 V G.H1.05 AF2 AF2
G.H1 58 K G.H1.06 AF2 AF2
G.H1 59 Q G.H1.07 AF2 AF2
G.H1 60 M G.H1.08 AF2 AF2
G.H1 61 R G.H1.09 AF2 AF2
G.H1 62 I G.H1.10 AF2 AF2
G.H1 63 L G.H1.11 AF2 AF2
G.H1 64 H G.H1.12 AF2 AF2
G.h1ha 65 V G.h1ha.01 AF2 AF2
G.h1ha 66 N G.h1ha.02 AF2 AF2
G.h1ha 67 G G.h1ha.03 AF2 AF2
G.h1ha 68 F G.h1ha.04 AF2 AF2
G.h1ha 69 N G.h1ha.05 AF2 AF2
G.h1ha 70 G G.h1ha.06 AF2 AF2
G.h1ha 71 E G.h1ha.07 AF2 AF2
G.h1ha 72 G G.h1ha.08 AF2 AF2
G.h1ha 73 G G.h1ha.09 AF2 AF2
G.h1ha 74 E G.h1ha.10 AF2 AF2
G.h1ha 75 E G.h1ha.11 AF2 AF2
G.h1ha 76 D G.h1ha.12 AF2 AF2
G.h1ha 77 P G.h1ha.13 AF2 AF2
G.h1ha 78 Q G.h1ha.14 AF2 AF2
G.h1ha 79 A G.h1ha.15 AF2 AF2
G.h1ha 80 A G.h1ha.16 AF2 AF2
G.h1ha 81 R G.h1ha.17 AF2 AF2
G.h1ha 82 S G.h1ha.18 AF2 AF2
G.h1ha 83 N G.h1ha.19 AF2 AF2
G.h1ha 84 S G.h1ha.20 AF2 AF2
H.HA 85 D H.HA.01 AF2 AF2
H.HA 86 G H.HA.02 AF2 AF2
H.HA 87 E H.HA.03 AF2 AF2
H.HA 88 K H.HA.04 AF2 AF2
H.HA 89 A H.HA.05 AF2 AF2
H.HA 90 T H.HA.06 AF2 AF2
H.HA 91 K H.HA.07 AF2 AF2
H.HA 92 V H.HA.08 AF2 AF2
H.HA 93 Q H.HA.09 AF2 AF2
H.HA 94 D H.HA.10 AF2 AF2
H.HA 95 I H.HA.11 AF2 AF2
H.HA 96 K H.HA.12 AF2 AF2
H.HA 97 N H.HA.13 AF2 AF2
H.HA 98 N H.HA.14 AF2 AF2
H.HA 99 L H.HA.15 AF2 AF2
H.HA 100 K H.HA.16 AF2 AF2
H.HA 101 E H.HA.17 AF2 AF2
H.HA 102 A H.HA.18 AF2 AF2
H.HA 103 I H.HA.19 AF2 AF2
H.HA 104 E H.HA.20 AF2 AF2
H.HA 105 T H.HA.21 AF2 AF2
H.HA 106 I H.HA.22 AF2 AF2
H.HA 107 V H.HA.23 AF2 AF2
H.HA 108 A H.HA.24 AF2 AF2
H.HA 109 A H.HA.25 AF2 AF2
H.HA 110 M H.HA.26 AF2 AF2
H.HA 111 S H.HA.27 AF2 AF2
H.HA 112 N H.HA.28 AF2 AF2
H.HA 113 L H.HA.29 AF2 AF2
H.hahb 114 V H.hahb.01 AF2 AF2
H.hahb 115 P H.hahb.02 AF2 AF2
H.hahb 116 P H.hahb.03 AF2 AF2
H.hahb 117 V H.hahb.04 AF2 AF2
H.hahb 118 E H.hahb.05 AF2 AF2
H.hahb 119 L H.hahb.06 AF2 AF2
H.hahb 120 A H.hahb.07 AF2 AF2
H.hahb 121 N H.hahb.08 AF2 AF2
H.hahb 122 P H.hahb.09 AF2 AF2
H.HB 123 E H.HB.01 AF2 AF2
H.HB 124 N H.HB.02 AF2 AF2
H.HB 125 Q H.HB.03 AF2 AF2
H.HB 126 F H.HB.04 AF2 AF2
H.HB 127 R H.HB.05 AF2 AF2
H.HB 128 V H.HB.06 AF2 AF2
H.HB 129 D H.HB.07 AF2 AF2
H.HB 130 Y H.HB.08 AF2 AF2
H.HB 131 I H.HB.09 AF2 AF2
H.HB 132 L H.HB.10 AF2 AF2
H.HB 133 S H.HB.11 AF2 AF2
H.HB 134 V H.HB.12 AF2 AF2
H.HB 135 M H.HB.13 AF2 AF2
H.HB 136 N H.HB.14 AF2 AF2
H.hbhc 137 V H.hbhc.01 AF2 AF2
H.hbhc 138 P H.hbhc.02 AF2 AF2
H.hbhc 139 D H.hbhc.03 AF2 AF2
H.hbhc 140 F H.hbhc.04 AF2 AF2
H.hbhc 141 D H.hbhc.13 AF2 AF2
H.hbhc 142 F H.hbhc.14 AF2 AF2
H.hbhc 143 P H.hbhc.15 AF2 AF2
H.HC 144 P H.HC.01 AF2 AF2
H.HC 145 E H.HC.02 AF2 AF2
H.HC 146 F H.HC.03 AF2 AF2
H.HC 147 Y H.HC.04 AF2 AF2
H.HC 148 E H.HC.05 AF2 AF2
H.HC 149 H H.HC.06 AF2 AF2
H.HC 150 A H.HC.07 AF2 AF2
H.HC 151 K H.HC.08 AF2 AF2
H.HC 152 A H.HC.09 AF2 AF2
H.HC 153 L H.HC.10 AF2 AF2
H.HC 154 W H.HC.11 AF2 AF2
H.HC 155 E H.HC.12 AF2 AF2
H.hchd 156 D H.hchd.01 AF2 AF2
H.HD 157 E H.HD.01 AF2 AF2
H.HD 158 G H.HD.02 AF2 AF2
H.HD 159 V H.HD.03 AF2 AF2
H.HD 160 R H.HD.04 AF2 AF2
H.HD 161 A H.HD.05 AF2 AF2
H.HD 162 C H.HD.06 AF2 AF2
H.HD 163 Y H.HD.07 AF2 AF2
H.HD 164 E H.HD.08 AF2 AF2
H.HD 165 R H.HD.09 AF2 AF2
H.HD 166 S H.HD.10 AF2 AF2
H.HD 167 N H.HD.11 AF2 AF2
H.HD 168 E H.HD.12 AF2 AF2
H.hdhe 169 Y H.hdhe.01 AF2 AF2
H.hdhe 170 Q H.hdhe.02 AF2 AF2
H.hdhe 171 L H.hdhe.03 AF2 AF2
H.hdhe 172 I H.hdhe.04 AF2 AF2
H.hdhe 173 D H.hdhe.05 AF2 AF2
H.HE 174 C H.HE.01 AF2 AF2
H.HE 175 A H.HE.02 AF2 AF2
H.HE 176 Q H.HE.03 AF2 AF2
H.HE 177 Y H.HE.04 AF2 AF2
H.HE 178 F H.HE.05 AF2 AF2
H.HE 179 L H.HE.06 AF2 AF2
H.HE 180 D H.HE.07 AF2 AF2
H.HE 181 K H.HE.08 AF2 AF2
H.HE 182 I H.HE.09 AF2 AF2
H.HE 183 D H.HE.10 AF2 AF2
H.HE 184 V H.HE.11 AF2 AF2
H.HE 185 I H.HE.12 AF2 AF2
H.HE 186 K H.HE.13 AF2 AF2
H.hehf 187 Q H.hehf.01 AF2 AF2
H.hehf 188 A H.hehf.02 AF2 AF2
H.hehf 189 D H.hehf.03 AF2 AF2
H.hehf 190 Y H.hehf.04 AF2 AF2
H.hehf 191 V H.hehf.05 AF2 AF2
H.hehf 192 P H.hehf.06 AF2 AF2
H.hehf 193 S H.hehf.07 AF2 AF2
H.HF 194 D H.HF.01 AF2 AF2
H.HF 195 Q H.HF.02 AF2 AF2
H.HF 196 D H.HF.03 AF2 AF2
H.HF 197 L H.HF.04 AF2 AF2
H.HF 198 L H.HF.05 AF2 AF2
H.HF 199 R H.HF.06 AF2 AF2
G.hfs2 200 C G.hfs2.01 AF2 AF2
G.hfs2 201 R G.hfs2.02 AF2 AF2
G.hfs2 202 V G.hfs2.03 AF2 AF2
G.hfs2 203 L G.hfs2.04 AF2 AF2
G.hfs2 204 T G.hfs2.05 AF2 AF2
G.hfs2 205 S G.hfs2.06 Structure Structure
G.hfs2 206 G G.hfs2.07 Structure Structure
G.S2 207 I G.S2.01 Structure Structure
G.S2 208 F G.S2.02 Structure Structure
G.S2 209 E G.S2.03 Structure Structure
G.S2 210 T G.S2.04 Structure Structure
G.S2 211 K G.S2.05 Structure Structure
G.S2 212 F G.S2.06 Structure Structure
G.S2 213 Q G.S2.07 Structure Structure
G.S2 214 V G.S2.08 Structure Structure
G.s2s3 215 D G.s2s3.01 Structure Structure
G.s2s3 216 K G.s2s3.02 Structure Structure
G.S3 217 V G.S3.01 Structure Structure
G.S3 218 N G.S3.02 Structure Structure
G.S3 219 F G.S3.03 Structure Structure
G.S3 220 H G.S3.04 Structure Structure
G.S3 221 M G.S3.05 Structure Structure
G.S3 222 F G.S3.06 Structure Structure
G.S3 223 D G.S3.07 Structure Structure
G.S3 224 V G.S3.08 Structure Structure
G.s3h2 225 G G.s3h2.01 Structure Structure
G.s3h2 226 G G.s3h2.02 Structure AF2
G.s3h2 227 Q G.s3h2.03 Structure Structure
G.H2 228 R G.H2.01 Structure Structure
G.H2 229 D G.H2.02 Structure Structure
G.H2 230 E G.H2.03 Structure Structure
G.H2 231 R G.H2.04 Structure Structure
G.H2 232 R G.H2.05 Structure Structure
G.H2 233 K G.H2.06 Structure Structure
G.H2 234 W G.H2.07 Structure Structure
G.H2 235 I G.H2.08 Structure Structure
G.H2 236 Q G.H2.09 Structure Structure
G.H2 237 C G.H2.10 Structure Structure
G.h2s4 238 F G.h2s4.01 Structure Structure
G.h2s4 239 N G.h2s4.02 Structure Structure
G.h2s4 240 D G.h2s4.03 Structure Structure
G.h2s4 241 V G.h2s4.04 Structure Structure
G.h2s4 242 T G.h2s4.05 Structure Structure
G.S4 243 A G.S4.01 Structure Structure
G.S4 244 I G.S4.02 Structure Structure
G.S4 245 I G.S4.03 Structure Structure
G.S4 246 F G.S4.04 Structure Structure
G.S4 247 V G.S4.05 Structure Structure
G.S4 248 V G.S4.06 Structure Structure
G.S4 249 A G.S4.07 Structure Structure
G.s4h3 250 S G.s4h3.01 Structure Structure
G.s4h3 251 S G.s4h3.02 Structure Structure
G.s4h3 252 S G.s4h3.03 AF2 AF2
G.s4h3 253 Y G.s4h3.04 AF2 AF2
G.s4h3 254 N G.s4h3.05 AF2 AF2
G.s4h3 255 M G.s4h3.06 AF2 AF2
G.s4h3 256 V G.s4h3.07 AF2 AF2
G.s4h3 257 I G.s4h3.08 AF2 AF2
G.s4h3 258 R G.s4h3.09 AF2 AF2
G.s4h3 259 E G.s4h3.10 AF2 AF2
G.s4h3 260 D G.s4h3.11 AF2 AF2
G.s4h3 261 N G.s4h3.12 AF2 AF2
G.s4h3 262 Q G.s4h3.13 Structure Structure
G.s4h3 263 T G.s4h3.14 Structure Structure
G.s4h3 264 N G.s4h3.15 Structure Structure
G.H3 265 R G.H3.01 Structure Structure
G.H3 266 L G.H3.02 Structure Structure
G.H3 267 Q G.H3.03 Structure Structure
G.H3 268 E G.H3.04 Structure AF2
G.H3 269 A G.H3.05 Structure Structure
G.H3 270 L G.H3.06 Structure Structure
G.H3 271 N G.H3.07 Structure AF2
G.H3 272 L G.H3.08 Structure Structure
G.H3 273 F G.H3.09 Structure Structure
G.H3 274 K G.H3.10 Structure AF2
G.H3 275 S G.H3.11 Structure Structure
G.H3 276 I G.H3.12 Structure Structure
G.H3 277 W G.H3.13 Structure Structure
G.H3 278 N G.H3.14 Structure Structure
G.H3 279 N G.H3.15 Structure Structure
G.H3 280 R G.H3.16 Structure AF2
G.H3 281 W G.H3.17 Structure Structure
G.H3 282 L G.H3.18 Structure Structure
G.h3s5 283 R G.h3s5.01 Structure Structure
G.h3s5 284 T G.h3s5.02 Structure AF2
G.h3s5 285 I G.h3s5.03 Structure AF2
G.S5 286 S G.S5.01 Structure Structure
G.S5 287 V G.S5.02 Structure Structure
G.S5 288 I G.S5.03 Structure Structure
G.S5 289 L G.S5.04 Structure Structure
G.S5 290 F G.S5.05 Structure Structure
G.S5 291 L G.S5.06 Structure Structure
G.S5 292 N G.S5.07 Structure Structure
G.s5hg 293 K G.s5hg.01 AF2 AF2
G.HG 294 Q G.HG.01 AF2 AF2
G.HG 295 D G.HG.02 AF2 AF2
G.HG 296 L G.HG.03 AF2 AF2
G.HG 297 L G.HG.04 AF2 AF2
G.HG 298 A G.HG.05 AF2 AF2
G.HG 299 E G.HG.06 AF2 AF2
G.HG 300 K G.HG.07 AF2 AF2
G.HG 301 V G.HG.08 AF2 AF2
G.HG 302 L G.HG.09 AF2 AF2
G.HG 303 A G.HG.10 AF2 AF2
G.HG 304 G G.HG.11 AF2 AF2
G.HG 305 K G.HG.12 AF2 AF2
G.HG 306 S G.HG.13 AF2 AF2
G.HG 307 K G.HG.14 AF2 AF2
G.HG 308 I G.HG.15 Structure Structure
G.HG 309 E G.HG.16 Structure Structure
G.HG 310 D G.HG.17 Structure Structure
G.hgh4 311 Y G.hgh4.01 Structure Structure
G.hgh4 312 F G.hgh4.02 Structure Structure
G.hgh4 313 P G.hgh4.03 Structure Structure
G.hgh4 314 E G.hgh4.04 Structure Structure
G.hgh4 315 F G.hgh4.05 Structure Structure
G.hgh4 316 A G.hgh4.06 Structure Structure
G.hgh4 317 R G.hgh4.07 Structure Structure
G.hgh4 318 Y G.hgh4.08 Structure Structure
G.hgh4 319 T G.hgh4.09 Structure Structure
G.hgh4 320 T G.hgh4.10 Structure Structure
G.hgh4 321 P G.hgh4.11 Structure Structure
G.hgh4 322 E G.hgh4.12 Structure AF2
G.hgh4 323 D G.hgh4.13 Structure AF2
G.hgh4 324 A G.hgh4.14 Structure Structure
G.hgh4 325 T G.hgh4.15 Structure AF2
G.hgh4 326 P G.hgh4.16 Structure Structure
G.hgh4 327 E G.hgh4.17 Structure AF2
G.hgh4 328 P G.hgh4.18 Structure Structure
G.hgh4 329 G G.hgh4.19 Structure Structure
G.hgh4 330 E G.hgh4.20 Structure AF2
G.hgh4 331 D G.hgh4.21 Structure AF2
G.H4 332 P G.H4.01 Structure Structure
G.H4 333 R G.H4.02 Structure Structure
G.H4 334 V G.H4.03 Structure Structure
G.H4 335 T G.H4.04 Structure Structure
G.H4 336 R G.H4.05 Structure Structure
G.H4 337 A G.H4.06 Structure Structure
G.H4 338 K G.H4.07 Structure Structure
G.H4 339 Y G.H4.08 Structure Structure
G.H4 340 F G.H4.10 Structure Structure
G.H4 341 I G.H4.11 Structure Structure
G.H4 342 R G.H4.12 Structure Structure
G.H4 343 D G.H4.13 Structure Structure
G.H4 344 E G.H4.14 Structure Structure
G.H4 345 F G.H4.15 Structure Structure
G.H4 346 L G.H4.16 Structure Structure
G.H4 347 R G.H4.17 Structure Structure
G.h4s6 348 I G.h4s6.01 Structure Structure
G.h4s6 349 S G.h4s6.02 Structure Structure
G.h4s6 350 T G.h4s6.03 Structure Structure
G.h4s6 351 A G.h4s6.04 Structure Structure
G.h4s6 352 S G.h4s6.08 Structure Structure
G.h4s6 353 G G.h4s6.09 AF2 AF2
G.h4s6 354 D G.h4s6.10 AF2 AF2
G.h4s6 355 G G.h4s6.11 AF2 AF2
G.h4s6 356 R G.h4s6.12 Structure Structure
G.h4s6 357 H G.h4s6.13 Structure Structure
G.h4s6 358 Y G.h4s6.20 Structure Structure
G.S6 359 C G.S6.01 Structure Structure
G.S6 360 Y G.S6.02 Structure Structure
G.S6 361 P G.S6.03 Structure Structure
G.S6 362 H G.S6.04 Structure Structure
G.S6 363 F G.S6.05 Structure Structure
G.s6h5 364 T G.s6h5.01 AF2 AF2
G.s6h5 365 C G.s6h5.02 AF2 AF2
G.s6h5 366 A G.s6h5.03 AF2 AF2
G.s6h5 367 V G.s6h5.04 AF2 AF2
G.s6h5 368 D G.s6h5.05 AF2 AF2
G.H5 369 T G.H5.01 AF2 AF2
G.H5 370 E G.H5.02 AF2 AF2
G.H5 371 N G.H5.03 Structure Structure
G.H5 372 I G.H5.04 Structure Structure
G.H5 373 R G.H5.05 Structure Structure
G.H5 374 R G.H5.06 Structure Structure
G.H5 375 V G.H5.07 Structure Structure
G.H5 376 F G.H5.08 Structure Structure
G.H5 377 N G.H5.09 Structure Structure
G.H5 378 D G.H5.10 Structure Structure
G.H5 379 C G.H5.11 Structure Structure
G.H5 380 R G.H5.12 Structure Structure
G.H5 381 D G.H5.13 Structure Structure
G.H5 382 I G.H5.14 Structure Structure
G.H5 383 I G.H5.15 Structure Structure
G.H5 384 Q G.H5.16 Structure Structure
G.H5 385 R G.H5.17 Structure Structure
G.H5 386 M G.H5.18 Structure Structure
G.H5 387 H G.H5.19 Structure Structure
G.H5 388 L G.H5.20 Structure Structure
G.H5 389 R G.H5.21 Structure Structure
G.H5 390 Q G.H5.22 Structure Structure
G.H5 391 Y G.H5.23 Structure Structure
G.H5 392 E G.H5.24 Structure Structure
G.H5 393 L G.H5.25 Structure Structure
G.H5 394 L G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 346 from structure (81.8%), 77 from model (18.2%)
Residue sidechains - 342 from structure (80.9%), 81 from model (19.1%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 E - AF2 AF2
N-term 3 K - AF2 AF2
N-term 4 K - AF2 AF2
N-term 5 C - AF2 AF2
N-term 6 T - AF2 AF2
N-term 7 L - AF2 AF2
N-term 8 Y - AF2 AF2
N-term 9 F - AF2 AF2
N-term 10 L - AF2 AF2
N-term 11 V - AF2 AF2
N-term 12 L - AF2 AF2
N-term 13 L - AF2 AF2
N-term 14 P - AF2 AF2
N-term 15 F - AF2 AF2
N-term 16 F - AF2 AF2
N-term 17 M - AF2 AF2
N-term 18 I - AF2 AF2
N-term 19 L - AF2 AF2
N-term 20 V - AF2 AF2
N-term 21 T - AF2 AF2
N-term 22 A - AF2 AF2
N-term 23 E - AF2 AF2
N-term 24 L - AF2 AF2
N-term 25 E - AF2 AF2
N-term 26 E - AF2 AF2
N-term 27 S - AF2 AF2
N-term 28 P - AF2 AF2
N-term 29 E - AF2 AF2
N-term 30 D - AF2 AF2
N-term 31 S - AF2 AF2
N-term 32 I - AF2 AF2
N-term 33 Q - Structure Structure
N-term 34 L - Structure Structure
N-term 35 G - Structure Structure
N-term 36 V - Structure Structure
N-term 37 T - Structure Structure
N-term 38 R - Structure Structure
N-term 39 N - Structure Structure
N-term 40 K - Structure Structure
N-term 41 I - Structure Structure
N-term 42 M - Structure Structure
N-term 43 T - Structure Structure
N-term 44 A - Structure Structure
N-term 45 Q - Structure Structure
N-term 46 Y - Structure Structure
N-term 47 E - Structure Structure
N-term 48 C - Structure Structure
N-term 49 Y - Structure Structure
N-term 50 Q - Structure Structure
N-term 51 K - Structure Structure
N-term 52 I - Structure Structure
N-term 53 M - Structure Structure
N-term 54 Q - Structure Structure
N-term 55 D - AF2 AF2
N-term 56 P - AF2 AF2
N-term 57 I - AF2 AF2
N-term 58 Q - AF2 AF2
N-term 59 Q - AF2 AF2
N-term 60 A - AF2 AF2
N-term 61 E - AF2 AF2
N-term 62 G - AF2 AF2
N-term 63 V - AF2 AF2
N-term 64 Y - Structure Structure
N-term 65 C - Structure Structure
N-term 66 N - Structure Structure
N-term 67 R - Structure Structure
N-term 68 T - Structure Structure
N-term 69 W - Structure Structure
N-term 70 D - Structure Structure
N-term 71 G - Structure Structure
N-term 72 W - Structure Structure
N-term 73 L - Structure Structure
N-term 74 C - Structure Structure
N-term 75 W - Structure Structure
N-term 76 N - Structure Structure
N-term 77 D - Structure Structure
N-term 78 V - Structure Structure
N-term 79 A - Structure Structure
N-term 80 A - Structure Structure
N-term 81 G - Structure Structure
N-term 82 T - Structure Structure
N-term 83 E - Structure Structure
N-term 84 S - Structure Structure
N-term 85 M - Structure Structure
N-term 86 Q - Structure Structure
N-term 87 L - Structure Structure
N-term 88 C - Structure Structure
N-term 89 P - Structure Structure
N-term 90 D - Structure Structure
N-term 91 Y - Structure Structure
N-term 92 F - Structure Structure
N-term 93 Q - Structure Structure
N-term 94 D - Structure Structure
N-term 95 F - Structure Structure
N-term 96 D - Structure Structure
N-term 97 P - Structure Structure
N-term 98 S - Structure Structure
N-term 99 E - Structure Structure
N-term 100 K - Structure Structure
N-term 101 V - Structure Structure
N-term 102 T - Structure Structure
N-term 103 K - Structure Structure
N-term 104 I - Structure Structure
N-term 105 C - Structure Structure
N-term 106 D - Structure Structure
N-term 107 Q - AF2 AF2
N-term 108 D - AF2 AF2
N-term 109 G - AF2 AF2
N-term 110 N - Structure Structure
N-term 111 W - Structure Structure
N-term 112 F - Structure Structure
N-term 113 R - Structure Structure
N-term 114 H - Structure Structure
N-term 115 P - Structure Structure
N-term 116 A - Structure Structure
N-term 117 S - Structure Structure
N-term 118 N - Structure Structure
N-term 119 R - Structure Structure
N-term 120 T - Structure Structure
N-term 121 W - Structure Structure
N-term 122 T - Structure Structure
N-term 123 N - Structure Structure
N-term 124 Y - Structure Structure
N-term 125 T - Structure Structure
N-term 126 Q - Structure Structure
N-term 127 C - Structure Structure
N-term 128 N - Structure Structure
N-term 129 V - Structure Structure
TM1 130 N 1.28x28 Structure Structure
TM1 131 T 1.29x29 Structure Structure
TM1 132 H 1.30x30 Structure Structure
TM1 133 E 1.31x31 Structure Structure
TM1 134 K 1.32x32 Structure Structure
TM1 135 V 1.33x33 Structure Structure
TM1 136 K 1.34x34 Structure Structure
TM1 137 T 1.35x35 Structure Structure
TM1 138 A 1.36x36 Structure Structure
TM1 139 L 1.37x37 Structure Structure
TM1 140 N 1.38x38 Structure Structure
TM1 141 L 1.39x39 Structure Structure
TM1 142 F 1.40x40 Structure Structure
TM1 143 Y 1.41x41 Structure Structure
TM1 144 L 1.42x42 Structure Structure
TM1 145 T 1.43x43 Structure Structure
TM1 146 I 1.44x44 Structure Structure
TM1 147 I 1.45x45 Structure Structure
TM1 148 G 1.46x46 Structure Structure
TM1 149 H 1.47x47 Structure Structure
TM1 150 G 1.48x48 Structure Structure
TM1 151 L 1.49x49 Structure Structure
TM1 152 S 1.50x50 Structure Structure
TM1 153 I 1.51x51 Structure Structure
TM1 154 A 1.52x52 Structure Structure
TM1 155 S 1.53x53 Structure Structure
TM1 156 L 1.54x54 Structure Structure
TM1 157 L 1.55x55 Structure Structure
TM1 158 I 1.56x56 Structure Structure
TM1 159 S 1.57x57 Structure Structure
TM1 160 L 1.58x58 Structure Structure
TM1 161 G 1.59x59 Structure Structure
TM1 162 I 1.60x60 Structure Structure
TM1 163 F 1.61x61 Structure Structure
TM1 164 F 1.62x62 Structure Structure
TM1 165 Y 1.63x63 Structure Structure
TM1 166 F 1.64x64 Structure Structure
ICL1 167 K 12.48x48 Structure AF2
ICL1 168 S 12.49x49 Structure Structure
ICL1 169 L 12.50x50 Structure Structure
ICL1 170 S 12.51x51 Structure Structure
TM2 171 C 2.44x44 Structure Structure
TM2 172 Q 2.45x45 Structure Structure
TM2 173 R 2.46x46 Structure Structure
TM2 174 I 2.47x47 Structure Structure
TM2 175 T 2.48x48 Structure Structure
TM2 176 L 2.49x49 Structure Structure
TM2 177 H 2.50x50 Structure Structure
TM2 178 K 2.51x51 Structure Structure
TM2 179 N 2.52x52 Structure Structure
TM2 180 L 2.53x53 Structure Structure
TM2 181 F 2.54x54 Structure Structure
TM2 182 F 2.55x55 Structure Structure
TM2 183 S 2.56x56 Structure Structure
TM2 184 F 2.57x57 Structure Structure
TM2 185 V 2.58x58 Structure Structure
TM2 186 C 2.59x59 Structure Structure
TM2 187 N 2.60x60 Structure Structure
TM2 188 S 2.61x61 Structure Structure
TM2 189 V 2.62x62 Structure Structure
TM2 190 V 2.63x63 Structure Structure
TM2 191 T 2.64x64 Structure Structure
TM2 192 I 2.65x65 Structure Structure
TM2 193 I 2.66x66 Structure Structure
TM2 194 H 2.67x67 Structure Structure
TM2 195 L 2.68x68 Structure Structure
TM2 196 T 2.69x69 Structure Structure
TM2 197 A 2.70x70 Structure Structure
TM2 198 V 2.71x71 Structure Structure
ECL1 199 A - Structure Structure
ECL1 200 N - Structure Structure
ECL1 201 N - Structure Structure
ECL1 202 Q - Structure Structure
ECL1 203 A - Structure Structure
ECL1 204 L - Structure Structure
ECL1 205 V - Structure Structure
ECL1 206 A - Structure Structure
ECL1 207 T - Structure Structure
ECL1 208 N - Structure Structure
ECL1 209 P - Structure Structure
TM3 210 V 3.27x27 Structure Structure
TM3 211 S 3.28x28 Structure Structure
TM3 212 C 3.29x29 Structure Structure
TM3 213 K 3.30x30 Structure Structure
TM3 214 V 3.31x31 Structure Structure
TM3 215 S 3.32x32 Structure Structure
TM3 216 Q 3.33x33 Structure Structure
TM3 217 F 3.34x34 Structure Structure
TM3 218 I 3.35x35 Structure Structure
TM3 219 H 3.36x36 Structure Structure
TM3 220 L 3.37x37 Structure Structure
TM3 221 Y 3.38x38 Structure Structure
TM3 222 L 3.39x39 Structure Structure
TM3 223 M 3.40x40 Structure Structure
TM3 224 G 3.41x41 Structure Structure
TM3 225 C 3.42x42 Structure Structure
TM3 226 N 3.43x43 Structure Structure
TM3 227 Y 3.44x44 Structure Structure
TM3 228 F 3.45x45 Structure Structure
TM3 229 W 3.46x46 Structure Structure
TM3 230 M 3.47x47 Structure Structure
TM3 231 L 3.48x48 Structure Structure
TM3 232 C 3.49x49 Structure Structure
TM3 233 E 3.50x50 Structure Structure
TM3 234 G 3.51x51 Structure Structure
TM3 235 I 3.52x52 Structure Structure
TM3 236 Y 3.53x53 Structure Structure
TM3 237 L 3.54x54 Structure Structure
TM3 238 H 3.55x55 Structure Structure
TM3 239 T 3.56x56 Structure Structure
TM3 240 L 3.57x57 Structure Structure
TM3 241 I 3.58x58 Structure Structure
TM3 242 V 3.59x59 Structure Structure
TM3 243 V 3.60x60 Structure Structure
ICL2 244 A - Structure Structure
ICL2 245 V - Structure Structure
ICL2 246 F - Structure Structure
ICL2 247 A - Structure Structure
ICL2 248 E - Structure AF2
ICL2 249 K - Structure AF2
ICL2 250 Q - Structure AF2
TM4 251 H 4.41x42 Structure Structure
TM4 252 L 4.42x43 Structure Structure
TM4 253 M 4.43x44 Structure Structure
TM4 254 W 4.44x45 Structure Structure
TM4 255 Y 4.45x46 Structure Structure
TM4 256 Y 4.46x47 Structure Structure
TM4 257 F 4.47x48 Structure Structure
TM4 258 L 4.48x49 Structure Structure
TM4 259 G 4.49x491 Structure Structure
TM4 260 W 4.50x50 Structure Structure
TM4 261 G 4.51x51 Structure Structure
TM4 262 F 4.52x52 Structure Structure
TM4 263 P 4.53x53 Structure Structure
TM4 264 L 4.54x54 Structure Structure
TM4 265 I 4.55x55 Structure Structure
TM4 266 P 4.56x56 Structure Structure
TM4 267 A 4.57x57 Structure Structure
TM4 268 C 4.58x58 Structure Structure
TM4 269 I 4.59x59 Structure Structure
TM4 270 H 4.60x60 Structure Structure
TM4 271 A 4.61x61 Structure Structure
TM4 272 I 4.62x62 Structure Structure
TM4 273 A 4.63x63 Structure Structure
TM4 274 R 4.64x64 Structure Structure
TM4 275 S 4.65x65 Structure Structure
TM4 276 L 4.66x66 Structure Structure
TM4 277 Y 4.67x67 Structure Structure
TM4 278 Y 4.68x68 Structure Structure
ECL2 279 N - Structure Structure
ECL2 280 D - Structure Structure
ECL2 281 N - Structure Structure
ECL2 282 C 45.50x50 Structure Structure
ECL2 283 W 45.51x51 Structure Structure
ECL2 284 I 45.52x52 Structure Structure
ECL2 285 S - Structure Structure
ECL2 286 S - Structure Structure
ECL2 287 D - Structure Structure
TM5 288 T 5.33x34 Structure Structure
TM5 289 H 5.34x35 Structure Structure
TM5 290 L 5.35x36 Structure Structure
TM5 291 L 5.36x37 Structure Structure
TM5 292 Y 5.37x38 Structure Structure
TM5 293 I 5.38x381 Structure Structure
TM5 294 I 5.39x39 Structure Structure
TM5 295 H 5.40x40 Structure Structure
TM5 296 G 5.41x41 Structure Structure
TM5 297 P 5.42x42 Structure Structure
TM5 298 I 5.43x43 Structure Structure
TM5 299 C 5.44x44 Structure Structure
TM5 300 A 5.45x45 Structure Structure
TM5 301 A 5.46x46 Structure Structure
TM5 302 L 5.47x47 Structure Structure
TM5 303 L 5.48x48 Structure Structure
TM5 304 V 5.49x49 Structure Structure
TM5 305 N 5.50x50 Structure Structure
TM5 306 L 5.51x51 Structure Structure
TM5 307 F 5.52x52 Structure Structure
TM5 308 F 5.53x53 Structure Structure
TM5 309 L 5.54x54 Structure Structure
TM5 310 L 5.55x55 Structure Structure
TM5 311 N 5.56x56 Structure Structure
TM5 312 I 5.57x57 Structure Structure
TM5 313 V 5.58x58 Structure Structure
TM5 314 R 5.59x59 Structure Structure
TM5 315 V 5.60x60 Structure Structure
TM5 316 L 5.61x61 Structure Structure
TM5 317 I 5.62x62 Structure Structure
TM5 318 T 5.63x63 Structure Structure
TM5 319 K 5.64x64 Structure Structure
TM5 320 L 5.65x65 Structure Structure
TM5 321 K 5.66x66 Structure Structure
ICL3 322 V - Structure Structure
ICL3 323 T - Structure Structure
ICL3 324 H - AF2 AF2
ICL3 325 Q - AF2 AF2
ICL3 326 A - AF2 AF2
ICL3 327 E - AF2 AF2
ICL3 328 S - AF2 AF2
ICL3 329 N - Structure Structure
ICL3 330 L - Structure Structure
TM6 331 Y 6.35x35 Structure Structure
TM6 332 M 6.36x36 Structure Structure
TM6 333 K 6.37x37 Structure Structure
TM6 334 A 6.38x38 Structure Structure
TM6 335 V 6.39x39 Structure Structure
TM6 336 R 6.40x40 Structure Structure
TM6 337 A 6.41x41 Structure Structure
TM6 338 T 6.42x42 Structure Structure
TM6 339 L 6.43x43 Structure Structure
TM6 340 I 6.44x44 Structure Structure
TM6 341 L 6.45x45 Structure Structure
TM6 342 V 6.46x46 Structure Structure
TM6 343 P 6.47x47 Structure Structure
TM6 344 L 6.48x48 Structure Structure
TM6 345 L 6.49x49 Structure Structure
TM6 346 G 6.50x50 Structure Structure
TM6 347 I 6.51x51 Structure Structure
TM6 348 E 6.52x52 Structure Structure
TM6 349 F 6.53x53 Structure Structure
TM6 350 V 6.54x54 Structure Structure
TM6 351 L 6.55x55 Structure Structure
TM6 352 I 6.56x56 Structure Structure
TM6 353 P 6.57x57 Structure Structure
TM6 354 W 6.58x58 Structure Structure
ECL3 355 R - Structure Structure
ECL3 356 P - AF2 AF2
ECL3 357 E - AF2 AF2
ECL3 358 G - AF2 AF2
TM7 359 K 7.32x31 AF2 AF2
TM7 360 I 7.33x32 AF2 AF2
TM7 361 A 7.34x33 AF2 AF2
TM7 362 E 7.35x34 AF2 AF2
TM7 363 E 7.36x35 Structure Structure
TM7 364 V 7.37x36 Structure Structure
TM7 365 Y 7.38x37 Structure Structure
TM7 366 D 7.39x38 Structure Structure
TM7 367 Y 7.40x39 Structure Structure
TM7 368 I 7.41x40 Structure Structure
TM7 369 M 7.42x41 Structure Structure
TM7 370 H 7.43x42 Structure Structure
TM7 371 I 7.44x43 Structure Structure
TM7 372 L 7.45x44 Structure Structure
TM7 373 M 7.46x45 Structure Structure
TM7 374 H 7.47x46 Structure Structure
TM7 375 F 7.48x47 Structure Structure
TM7 376 Q 7.49x49 Structure Structure
TM7 377 G 7.50x50 Structure Structure
TM7 378 L 7.51x51 Structure Structure
TM7 379 L 7.52x52 Structure Structure
TM7 380 V 7.53x53 Structure Structure
TM7 381 S 7.54x54 Structure Structure
TM7 382 T 7.55x55 Structure Structure
TM7 383 I 7.56x56 Structure Structure
TM7 384 F 7.57x57 Structure Structure
TM7 385 C 7.58x58 Structure Structure
TM7 386 F 7.59x59 Structure Structure
TM7 387 F 7.60x60 Structure Structure
H8 388 N 8.47x47 Structure Structure
H8 389 G 8.48x48 Structure Structure
H8 390 E 8.49x49 Structure Structure
H8 391 V 8.50x50 Structure Structure
H8 392 Q 8.51x51 Structure Structure
H8 393 A 8.52x52 Structure Structure
H8 394 I 8.53x53 Structure Structure
H8 395 L 8.54x54 Structure Structure
H8 396 R 8.55x55 Structure Structure
H8 397 R 8.56x56 Structure Structure
H8 398 N 8.57x57 Structure Structure
H8 399 W 8.58x58 Structure Structure
H8 400 N 8.59x59 Structure Structure
H8 401 Q 8.60x60 Structure Structure
H8 402 Y 8.61x61 Structure Structure
H8 403 K 8.62x62 AF2 AF2
H8 404 I 8.63x63 AF2 AF2
H8 405 Q 8.64x64 AF2 AF2
H8 406 F 8.65x65 AF2 AF2
H8 407 G 8.66x66 AF2 AF2
H8 408 N 8.67x67 AF2 AF2
H8 409 S 8.68x68 AF2 AF2
H8 410 F 8.69x69 AF2 AF2
H8 411 S 8.70x70 AF2 AF2
H8 412 N 8.71x71 AF2 AF2
H8 413 S 8.72x72 AF2 AF2
C-term 414 E - AF2 AF2
C-term 415 A - AF2 AF2
C-term 416 L - AF2 AF2
C-term 417 R - AF2 AF2
C-term 418 S - AF2 AF2
C-term 419 A - AF2 AF2
C-term 420 S - AF2 AF2
C-term 421 Y - AF2 AF2
C-term 422 T - AF2 AF2
C-term 423 V - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Aromatic TM2 R 173 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 173 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 173 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM3 Y 236 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 V 245 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 V 245 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 F 246 - G.S3 F 219 G.S3.03
Polar ICL2 E 248 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 E 248 - G.HN Q 35 G.HN.52
Polar TM3 L 240 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 240 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 240 3x57 G.H5 H 387 G.H5.19
Hydrophobic ICL2 K 249 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 K 249 - G.HN Q 35 G.HN.52
Polar ICL2 E 248 - G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 E 248 - G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 E 248 - G.hns1 A 39 G.hns1.03
Polar TM5 K 319 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 319 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 319 5x64 G.H5 Q 384 G.H5.16
Van-der-waals H8 E 390 8x49 G.H5 E 392 G.H5.24
Polar ICL3 Q 325 - G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL3 V 322 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 V 322 - G.H5 R 385 G.H5.17
Hydrophobic ICL2 E 248 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 E 248 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 K 249 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 K 249 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 F 246 - G.S3 V 217 G.S3.01
Hydrophobic TM6 A 337 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM5 K 319 5x64 G.H5 L 388 G.H5.20
Hydrophobic TM5 L 316 5x61 G.H5 L 388 G.H5.20
Van-der-waals TM5 L 316 5x61 G.H5 L 388 G.H5.20
Polar TM6 R 336 6x40 G.H5 E 392 G.H5.24
Van-der-waals TM6 R 336 6x40 G.H5 E 392 G.H5.24
Hydrophobic TM5 L 316 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 L 316 5x61 G.H5 L 393 G.H5.25
Aromatic ICL2 F 246 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 246 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 246 - G.S1 H 41 G.S1.02
Aromatic ICL2 F 246 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 246 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 246 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 V 245 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 V 245 - G.H5 Q 384 G.H5.16
Hydrophobic TM7 F 384 7x57 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 320 5x65 G.H5 L 394 G.H5.26
Hydrophobic TM3 L 237 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 237 3x54 G.H5 Y 391 G.H5.23
Polar H8 G 389 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 G 389 8x48 G.H5 E 392 G.H5.24
Ionic H8 E 390 8x49 G.h4s6 R 356 G.h4s6.12
Hydrophobic TM2 H 177 2x50 G.H5 Y 391 G.H5.23
Polar TM5 K 319 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 319 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 K 319 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM3 L 240 3x57 G.H5 Y 391 G.H5.23
Hydrophobic TM3 I 241 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 241 3x58 G.H5 L 388 G.H5.20
Hydrophobic ICL2 V 245 - G.H5 I 383 G.H5.15
Hydrophobic TM3 I 241 3x58 G.H5 H 387 G.H5.19
Ionic TM5 K 319 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 319 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 319 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 319 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM6 L 341 6x45 G.H5 L 393 G.H5.25
Polar H8 N 388 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM5 I 312 5x57 G.H5 L 393 G.H5.25
Polar TM3 V 242 3x59 G.H5 R 380 G.H5.12
Van-der-waals TM3 V 242 3x59 G.H5 R 380 G.H5.12
Hydrophobic ICL2 F 246 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 246 - G.H5 R 380 G.H5.12
Polar TM3 I 241 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 241 3x58 G.H5 Q 384 G.H5.16
Polar ICL2 V 245 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 V 245 - G.H5 H 387 G.H5.19
Polar TM2 R 173 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 173 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM5 L 316 5x61 G.H5 L 394 G.H5.26
Hydrophobic TM6 I 340 6x44 G.H5 L 393 G.H5.25