mGlu5 receptor - Gi1

GPCR CLASS (FAMILY)

Class C (Glutamate)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

X

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9WQK

RESOLUTION

3.7 Å

REFERENCE

10.1126/SCIADV.AEE0044

PUBLICATION DATE

May 27, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

77 interactions (Click to see)

LIGANDS

L-glutamic acid - Agonist pubchem gtoplig chembl_ligand drugbank drug_central chembl_ligand pubchem pubchem drugbank ,

CDPPB - PAM pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

L-glutamic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Aromatic C-term F 837 - G.H5 F 354 G.H5.26
Hydrophobic C-term F 837 - G.H5 F 354 G.H5.26
Van-der-waals C-term F 837 - G.H5 F 354 G.H5.26
Polar TM3 R 668 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 668 3x53 G.H5 C 351 G.H5.23
Van-der-waals ICL1 K 611 12x51 G.H5 G 352 G.H5.24
Polar H8 R 834 8x51 G.H5 K 345 G.H5.17
Hydrophobic H8 R 834 8x51 G.H5 K 345 G.H5.17
Van-der-waals H8 R 834 8x51 G.H5 K 345 G.H5.17
Hydrophobic TM3 I 672 3x57 G.H5 L 353 G.H5.25
Van-der-waals TM3 I 672 3x57 G.H5 L 353 G.H5.25
Polar ICL1 S 612 12x52 G.H5 L 353 G.H5.25
Hydrophobic ICL1 S 612 12x52 G.H5 L 353 G.H5.25
Van-der-waals ICL1 S 612 12x52 G.H5 L 353 G.H5.25
Hydrophobic H8 R 834 8x51 G.h4s6 T 316 G.h4s6.10
Van-der-waals H8 R 834 8x51 G.h4s6 T 316 G.h4s6.10
Hydrophobic H8 R 834 8x51 G.H5 F 354 G.H5.26
Van-der-waals H8 R 834 8x51 G.H5 F 354 G.H5.26
Hydrophobic ICL2 T 682 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 T 682 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 I 680 - G.H5 F 336 G.H5.08
Hydrophobic ICL1 K 611 12x51 G.H5 L 353 G.H5.25
Van-der-waals ICL1 K 611 12x51 G.H5 L 353 G.H5.25
Hydrophobic C-term F 837 - G.H5 K 345 G.H5.17
Hydrophobic ICL2 K 683 - G.hns1 R 32 G.hns1.03
Polar ICL2 T 682 - G.hns1 A 31 G.hns1.02
Hydrophobic TM2 S 614 2x35 G.H5 L 353 G.H5.25
Van-der-waals TM2 S 614 2x35 G.H5 L 353 G.H5.25
Hydrophobic ICL2 I 680 - G.H5 T 340 G.H5.12
Hydrophobic TM3 I 672 3x57 G.H5 C 351 G.H5.23
Van-der-waals TM3 I 672 3x57 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 672 3x57 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 672 3x57 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 669 3x54 G.H5 L 353 G.H5.25
Polar ICL2 M 688 - G.H5 C 351 G.H5.23
Hydrophobic ICL2 M 688 - G.H5 C 351 G.H5.23
Van-der-waals ICL2 M 688 - G.H5 C 351 G.H5.23
Polar H8 R 834 8x51 G.h4s6 D 315 G.h4s6.09
Hydrophobic H8 R 834 8x51 G.h4s6 D 315 G.h4s6.09
Van-der-waals H8 R 834 8x51 G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL2 T 682 - G.H5 I 343 G.H5.15
Polar ICL1 K 611 12x51 G.H5 F 354 G.H5.26
Hydrophobic ICL1 K 611 12x51 G.H5 F 354 G.H5.26
Van-der-waals ICL1 K 611 12x51 G.H5 F 354 G.H5.26
Hydrophobic TM3 L 673 3x58 G.H5 I 344 G.H5.16
Hydrophobic ICL3 F 768 - G.H5 L 348 G.H5.20
Van-der-waals ICL3 F 768 - G.H5 L 348 G.H5.20
Hydrophobic H8 S 835 8x52 G.h4s6 E 318 G.h4s6.12
Van-der-waals H8 S 835 8x52 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 R 668 3x53 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 668 3x53 G.H5 L 353 G.H5.25