SST3 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8XIR

RESOLUTION

2.5 Å

REFERENCE

PUBLICATION DATE

July 3, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

59 interactions (Click to see)

LIGANDS

004-DTR-LYS-TY5-PHE-A1D5E - Agonist

PHYSIOLOGICAL LIGANDS

cortistatin-14, SRIF-14, CST-17, SRIF-28



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 148 34x50 G.H5 I 350 G.H5.15
Hydrophobic TM3 R 141 3x50 G.H5 C 358 G.H5.23
Hydrophobic TM5 I 229 5x61 G.H5 L 360 G.H5.25
Polar ICL4 R 319 - G.H5 D 357 G.H5.22
Van-der-waals ICL4 R 319 - G.H5 D 357 G.H5.22
Hydrophobic ICL2 P 148 34x50 G.H5 N 354 G.H5.19
Van-der-waals ICL2 P 148 34x50 G.H5 N 354 G.H5.19
Hydrophobic TM5 V 240 5x72 G.H5 N 344 G.H5.09
Van-der-waals TM5 V 240 5x72 G.H5 N 344 G.H5.09
Hydrophobic TM6 V 255 6x33 G.H5 L 360 G.H5.25
Van-der-waals TM6 V 255 6x33 G.H5 L 360 G.H5.25
Polar ICL4 Y 318 - G.H5 G 359 G.H5.24
Hydrophobic ICL4 Y 318 - G.H5 G 359 G.H5.24
Hydrophobic TM5 K 232 5x64 G.H5 I 351 G.H5.16
Hydrophobic TM5 V 240 5x72 G.S6 Y 327 G.S6.02
Van-der-waals TM5 V 240 5x72 G.S6 Y 327 G.S6.02
Hydrophobic ICL3 W 241 - G.S6 C 326 G.S6.01
Van-der-waals ICL3 W 241 - G.S6 C 326 G.S6.01
Hydrophobic TM2 T 79 2x39 G.H5 C 358 G.H5.23
Van-der-waals TM2 T 79 2x39 G.H5 C 358 G.H5.23
Hydrophobic ICL3 W 241 - G.H4 L 313 G.H4.16
Van-der-waals ICL3 W 241 - G.H4 L 313 G.H4.16
Van-der-waals ICL2 R 153 34x55 G.hns1 R 31 G.hns1.02
Hydrophobic TM3 R 141 3x50 G.H5 L 360 G.H5.25
Hydrophobic TM5 A 236 5x68 G.H5 I 351 G.H5.16
Van-der-waals ICL3 Q 246 - G.H5 K 352 G.H5.17
Polar TM3 A 144 3x53 G.H5 N 354 G.H5.19
Hydrophobic TM3 A 144 3x53 G.H5 N 354 G.H5.19
Van-der-waals TM3 A 144 3x53 G.H5 N 354 G.H5.19
Polar TM2 T 79 2x39 G.H5 D 357 G.H5.22
Hydrophobic TM5 I 229 5x61 G.H5 L 355 G.H5.20
Hydrophobic TM5 V 240 5x72 G.H5 D 348 G.H5.13
Hydrophobic TM3 V 145 3x54 G.H5 I 351 G.H5.16
Van-der-waals TM3 V 145 3x54 G.H5 I 351 G.H5.16
Hydrophobic TM6 V 255 6x33 G.H5 F 361 G.H5.26
Hydrophobic TM3 A 144 3x53 G.H5 C 358 G.H5.23
Hydrophobic TM6 V 259 6x37 G.H5 L 360 G.H5.25
Van-der-waals TM6 V 259 6x37 G.H5 L 360 G.H5.25
Hydrophobic TM6 S 251 6x29 G.H5 F 361 G.H5.26
Van-der-waals TM6 S 251 6x29 G.H5 F 361 G.H5.26
Hydrophobic TM5 R 239 5x71 G.H5 N 344 G.H5.09
Hydrophobic ICL4 Y 318 - G.H5 F 361 G.H5.26
Van-der-waals ICL4 Y 318 - G.H5 F 361 G.H5.26
Hydrophobic TM5 V 233 5x65 G.H5 L 355 G.H5.20
Van-der-waals TM5 V 233 5x65 G.H5 L 355 G.H5.20
Polar ICL4 S 317 - G.H5 G 359 G.H5.24
Hydrophobic TM5 V 240 5x72 G.H5 D 345 G.H5.10
Van-der-waals TM5 V 240 5x72 G.H5 D 345 G.H5.10
Hydrophobic TM5 V 233 5x65 G.H5 I 351 G.H5.16
Hydrophobic TM3 V 145 3x54 G.H5 L 355 G.H5.20
Van-der-waals TM3 V 145 3x54 G.H5 L 355 G.H5.20
Polar ICL2 A 152 34x54 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 A 152 34x54 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 A 152 34x54 G.hns1 R 31 G.hns1.02
Hydrophobic ICL3 W 241 - G.S6 P 328 G.S6.03
Van-der-waals ICL3 W 241 - G.S6 P 328 G.S6.03
Hydrophobic TM3 V 145 3x54 G.H5 N 354 G.H5.19
Hydrophobic TM5 Y 226 5x58 G.H5 L 360 G.H5.25
Van-der-waals TM5 Y 226 5x58 G.H5 L 360 G.H5.25