PDB
8XIR
Resolution
2.5 Å
Released
July 3, 2024
Receptor
SST3
Class
A
Species
Homo sapiens
Ligand
Function
pasireotide
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
pasireotide F93 2.53x53 TM2 Van der Waals
pasireotide G96 2.56x56 TM2 Van der Waals
pasireotide F99 2.59x59 TM2 hydrophobic
pasireotide L100 2.60x60 TM2 hydrophobic
pasireotide Q103 2.63x63 TM2 Van der Waals
pasireotide N104 2.64x64 TM2 Van der Waals
pasireotide W109 23.50x50 ECL1 hydrophobic
pasireotide V119 3.28x28 TM3 hydrophobic
pasireotide M120 3.29x29 TM3 hydrophobic
pasireotide D123 3.32x32 TM3 hydrophobic
pasireotide D123 3.32x32 TM3 polar (hydrogen bond)
pasireotide D123 3.32x32 TM3 polar (charge-charge)
pasireotide Q127 3.36x36 TM3 polar (hydrogen bond)
pasireotide C191 45.50x50 ECL2 Van der Waals
pasireotide H192 45.51x51 ECL2 Van der Waals
pasireotide M193 45.52x52 ECL2 hydrophobic
pasireotide W195 ECL2 hydrophobic
pasireotide W195 ECL2 aromatic (edge-to-face)
pasireotide R203 5.35x36 TM5 Van der Waals
pasireotide T210 5.42x43 TM5 hydrophobic
pasireotide F273 6.51x51 TM6 hydrophobic
pasireotide F273 6.51x51 TM6 aromatic (edge-to-face)
pasireotide Y274 6.52x52 TM6 Van der Waals
pasireotide N277 6.55x55 TM6 Van der Waals
pasireotide L285 ECL3 Van der Waals
pasireotide E287 ECL3 Van der Waals
pasireotide F291 7.31x30 TM7 hydrophobic
pasireotide F292 7.32x31 TM7 hydrophobic
pasireotide Y295 7.35x34 TM7 hydrophobic
pasireotide V299 7.39x38 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 T A S P ICL1ECL1 Y W P F ECL1ICL2 P T R S A R W R ICL2ECL2 G V P R G M S T C H M Q W P E ECL2ICL3 W A P S C Q R ICL3ECL3 P L P E ECL3N-term M D M L H P S S V S T T S E P E N A S S A W P P D A T L G N V S A G P S P A G L A N-termC-term R P S R R V R S Q E P T V G P P E K T E E E D E E E E D G E E S R E G G K G K E M N G R V S Q I T Q P G T S G Q E R P P S R V A S K E Q Q L L P Q E A S T G E K S S T M R I S Y L C-term V S G V L I P L V Y L V V C V V G L L G N S L V I Y V V L R H S V T N V Y I L N L A L A D E L F M L G L P F L A A Q N A L S G S L M C R L V M A V D G I N Q F T S I F C L T V M S V D R Y L A V V H T A P V A R T V S A A V W V A S A V V V L P V V V F S P A A A W R A G F I I Y T A A L G F F G P L L V I C L C Y L L I V V K V R S A G R R V R R R S E R R V T R M V V A V V A L F V L C W M P F Y V L N I V N V V C E P A F F G L Y F L V V A L P Y A N S C A N P I L Y G F L S Y R F R R F K Q G V L L
Helix box plot — Download: PNG | SVG S N G L L G V V C V V L Y V L P I L V G 1 L N L A L A D E L F M L G L P F L A A Q 2 V T L C F I S T F Q N I G D V A M V L R 3 A R T V S A A V W V A S A V V V L P V 4 Y C L C I V L L P G F F G L A A T Y I I F 5 V A V V A L F V L C W M P F Y V L N I V 6 I P N A C S N A Y P L A V V L F Y L G 7

GPCRdb(A)
GPCRdb(A)
SST3 receptor
TM2
2x53 2.53x53 F93
2x56 2.56x56 G96
2x59 2.59x59 F99
2x60 2.60x60 L100
2x63 2.63x63 Q103
2x64 2.64x64 N104
ECL1
23x50 23.50x50 W109
TM3
3x28 3.28x28 V119
3x29 3.29x29 M120
3x32 3.32x32 D123
3x36 3.36x36 Q127
ECL2
45x50 45.50x50 C191
45x51 45.51x51 H192
45x52 45.52x52 M193
TM5
5x36 5.35x36 R203
5x43 5.42x43 T210
TM6
6x51 6.51x51 F273
6x52 6.52x52 Y274
6x55 6.55x55 N277
TM7
7x30 7.31x30 F291
7x31 7.32x31 F292
7x34 7.35x34 Y295
7x38 7.39x38 V299