TAS2R4 (ta2r4_human)
FAMILY
Class T2 (Taste 2) Sensory receptors Taste 2 receptors TAS2R4
GENE
TAS2R4
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Taste receptor type 2 member 4, T2R4
SOURCE
SWISSPROT
SEQUENCE
N-term | TM1 | ||||||||
M
|
L
|
R
|
L
|
F
|
Y
|
F
|
S
|
A
|
I
|
10 |
I
|
A
|
S
|
V
|
I
|
L
|
N
|
F
|
V
|
G
|
20 |
I
|
I
|
M
|
N
|
L
|
F
|
I
|
T
|
V
|
V
|
30 |
N
|
C
|
K
|
T
|
W
|
V
|
K
|
S
|
H
|
R
|
40 |
ICL1 | TM2 | ||||||||
I
|
S
|
S
|
S
|
D
|
R
|
I
|
L
|
F
|
S
|
50 |
L
|
G
|
I
|
T
|
R
|
F
|
L
|
M
|
L
|
G
|
60 |
L
|
F
|
L
|
V
|
N
|
T
|
I
|
Y
|
F
|
V
|
70 |
ECL1 | TM3 | ||||||||
S
|
S
|
N
|
T
|
E
|
R
|
S
|
V
|
Y
|
L
|
80 |
S
|
A
|
F
|
F
|
V
|
L
|
C
|
F
|
M
|
F
|
90 |
L
|
D
|
S
|
S
|
S
|
V
|
W
|
F
|
V
|
T
|
100 |
L
|
L
|
N
|
I
|
L
|
Y
|
C
|
V
|
K
|
I
|
110 |
ICL2 | |||||||||
T
|
N
|
F
|
Q
|
H
|
S
|
V
|
F
|
L
|
L
|
120 |
TM4 | |||||||||
L
|
K
|
R
|
N
|
I
|
S
|
P
|
K
|
I
|
P
|
130 |
R
|
L
|
L
|
L
|
A
|
C
|
V
|
L
|
I
|
S
|
140 |
A
|
F
|
T
|
T
|
C
|
L
|
Y
|
I
|
T
|
L
|
150 |
ECL2 | |||||||||
S
|
Q
|
A
|
S
|
P
|
F
|
P
|
E
|
L
|
V
|
160 |
T
|
T
|
R
|
N
|
N
|
T
|
S
|
F
|
N
|
I
|
170 |
TM5 | |||||||||
S
|
E
|
G
|
I
|
L
|
S
|
L
|
V
|
V
|
S
|
180 |
L
|
V
|
L
|
S
|
S
|
S
|
L
|
Q
|
F
|
I
|
190 |
I
|
N
|
V
|
T
|
S
|
A
|
S
|
L
|
L
|
I
|
200 |
H
|
S
|
L
|
R
|
R
|
H
|
I
|
Q
|
K
|
M
|
210 |
ICL3 | |||||||||
Q
|
K
|
N
|
A
|
T
|
G
|
F
|
W
|
N
|
P
|
220 |
TM6 | |||||||||
Q
|
T
|
E
|
A
|
H
|
V
|
G
|
A
|
M
|
K
|
230 |
L
|
M
|
V
|
Y
|
F
|
L
|
I
|
L
|
Y
|
I
|
240 |
P
|
Y
|
S
|
V
|
A
|
T
|
L
|
V
|
Q
|
Y
|
250 |
ECL3 | |||||||||
L
|
P
|
F
|
Y
|
A
|
G
|
M
|
D
|
M
|
G
|
260 |
TM7 | |||||||||
T
|
K
|
S
|
I
|
C
|
L
|
I
|
F
|
A
|
T
|
270 |
L
|
Y
|
S
|
P
|
G
|
H
|
S
|
V
|
L
|
I
|
280 |
H8 | |||||||||
I
|
I
|
T
|
H
|
P
|
K
|
L
|
K
|
T
|
T
|
290 |
A
|
K
|
K
|
I
|
L
|
C
|
F
|
K
|
K
|
DIAGRAMS
7TM
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
No physiological ligands available
STRUCTURE MODELS
STRUCTURES
No structures available