TAS2R4 - Ggust

GPCR CLASS (FAMILY)

Class T2 (Taste 2)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.3 Å

REFERENCE

PUBLICATION DATE

July 15, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

Apo (no ligand) -

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic TM3 L 105 3x49 G.H5 C 351 G.H5.23
Hydrophobic H8 P 285 8x48 G.H5 L 353 G.H5.25
Van-der-waals H8 P 285 8x48 G.H5 L 353 G.H5.25
Hydrophobic H8 H 284 8x47 G.H5 L 353 G.H5.25
Van-der-waals H8 H 284 8x47 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 110 3x54 G.H5 L 348 G.H5.20
Polar TM2 S 44 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 S 44 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM6 A 224 6x30 G.H5 L 353 G.H5.25
Hydrophobic TM6 Q 221 6x27 G.H5 I 344 G.H5.16
Hydrophobic H8 P 285 8x48 G.H5 F 354 G.H5.26
Polar TM3 K 109 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 K 109 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 K 109 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 Y 106 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 Y 106 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 K 109 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 K 109 3x53 G.H5 C 351 G.H5.23
Polar TM2 S 42 2x37 G.H5 C 351 G.H5.23
Hydrophobic TM2 S 42 2x37 G.H5 C 351 G.H5.23
Van-der-waals TM2 S 42 2x37 G.H5 C 351 G.H5.23
Hydrophobic H8 K 286 8x49 G.H5 F 354 G.H5.26
Van-der-waals H8 K 286 8x49 G.H5 F 354 G.H5.26
Polar TM2 S 42 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 S 42 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 S 42 2x37 G.H5 D 350 G.H5.22