TAS2R4 - Ggust

GPCR CLASS (FAMILY)

Class T2 (Taste 2)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

June 24, 2026

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

L-Trp-Trp-Trp - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic H8 P 285 8x48 G.H5 L 353 G.H5.25
Hydrophobic H8 H 284 8x47 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 110 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 110 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 H 225 6x31 G.H5 I 344 G.H5.16
Van-der-waals TM6 H 225 6x31 G.H5 I 344 G.H5.16
Aromatic ICL3 W 218 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 W 218 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 W 218 - G.S6 Y 320 G.S6.02
Polar ICL3 F 217 - G.H4 K 304 G.H4.12
Hydrophobic ICL3 F 217 - G.H4 K 304 G.H4.12
Van-der-waals ICL3 F 217 - G.H4 K 304 G.H4.12
Hydrophobic TM6 A 224 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 224 6x30 G.H5 F 354 G.H5.26
Hydrophobic TM5 M 210 5x72 G.H5 D 341 G.H5.13
Hydrophobic H8 P 285 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM7 T 283 7x56 G.H5 L 353 G.H5.25
Hydrophobic TM5 H 206 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM3 K 109 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 K 109 3x53 G.H5 N 347 G.H5.19
Polar TM5 N 213 5x75 G.H5 D 337 G.H5.09
Van-der-waals TM5 N 213 5x75 G.H5 D 337 G.H5.09
Hydrophobic TM3 Y 106 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL3 F 217 - G.S6 H 322 G.S6.04
Hydrophobic TM3 K 109 3x53 G.H5 C 351 G.H5.23
Ionic TM5 H 206 5x68 G.H5 D 341 G.H5.13
Polar TM5 H 206 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 H 206 5x68 G.H5 D 341 G.H5.13
Polar ICL2 Q 114 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 Q 114 - G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 Q 114 - G.s2s3 D 193 G.s2s3.02
Hydrophobic H8 P 285 8x48 G.H5 G 352 G.H5.24
Polar TM4 N 124 4x37 G.HN R 24 G.HN.48
Polar ICL3 W 218 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 F 217 - G.S6 M 323 G.S6.05
Van-der-waals ICL3 F 217 - G.S6 M 323 G.S6.05
Aromatic ICL3 W 218 - G.H5 F 334 G.H5.06
Hydrophobic ICL3 W 218 - G.H5 F 334 G.H5.06
Polar TM3 I 110 3x54 G.H5 N 347 G.H5.19