FPR1 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7VFX

RESOLUTION

2.8 Å

REFERENCE

10.1038/S41467-022-32822-Y

PUBLICATION DATE

Sept. 21, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

40 interactions (Click to see)

LIGANDS

Peptide agonist fMet-Ile-Phe-Leu - Agonist pubchem

PHYSIOLOGICAL LIGANDS

annexin I, fMet-Leu-Phe, cathepsin G, spinorphin



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 R 238 6x32 G.H5 L 353 G.H5.25
Hydrophobic ICL3 L 233 - G.H5 K 345 G.H5.17
Polar ICL2 Q 134 34x54 G.S1 E 33 G.S1.01
Hydrophobic ICL2 Q 134 34x54 G.S3 L 194 G.S3.01
Hydrophobic ICL2 Q 134 34x54 G.H5 I 343 G.H5.15
Hydrophobic ICL2 P 130 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM6 V 242 6x36 G.H5 L 353 G.H5.25
Polar TM2 T 60 2x39 G.H5 D 350 G.H5.22
Polar ICL2 N 135 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 N 135 34x55 G.s2s3 D 193 G.s2s3.02
Polar TM2 Y 64 2x43 G.H5 C 351 G.H5.23
Polar TM6 R 238 6x32 G.H5 G 352 G.H5.24
Hydrophobic ICL3 I 234 - G.H5 F 354 G.H5.26
Hydrophobic ICL2 Q 134 34x54 G.S1 V 34 G.S1.02
Polar ICL2 Q 134 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 134 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 K 227 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM5 I 228 5x65 G.H5 L 348 G.H5.20
Polar TM6 P 239 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 P 239 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 P 239 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 V 131 34x51 G.H5 T 340 G.H5.12
Hydrophobic TM4 T 138 4x38 G.HN E 28 G.HN.52
Polar ICL2 T 133 34x53 G.H5 N 347 G.H5.19
Polar TM3 C 126 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 C 126 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 V 131 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM3 R 123 3x50 G.H5 L 353 G.H5.25
Polar ICL2 Q 134 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL3 L 233 - G.H5 L 348 G.H5.20
Van-der-waals ICL3 L 233 - G.H5 L 348 G.H5.20
Hydrophobic TM6 L 243 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 243 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL3 L 233 - G.H5 F 354 G.H5.26
Polar TM3 R 123 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 123 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 127 3x54 G.H5 L 348 G.H5.20
Polar TM4 S 140 4x40 G.HN E 28 G.HN.52
Hydrophobic TM4 S 140 4x40 G.HN E 28 G.HN.52
Polar ICL3 K 235 - G.H5 F 354 G.H5.26
Aromatic ICL3 K 235 - G.H5 F 354 G.H5.26
Hydrophobic ICL3 K 235 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 K 235 - G.H5 F 354 G.H5.26
Hydrophobic ICL2 P 130 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 130 34x50 G.H5 I 343 G.H5.15