PDB
7VFX
Resolution
2.8 Å
Released
Sept. 21, 2022
Receptor
FPR1
Class
A
Species
Homo sapiens
Ligand
fMIFL
Function
Agonist
Reference
10.1038/S41467-022-32822-Y

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Ligand Amino Acid Generic Number Segment Interaction Type
fMIFL F102 3.29x29 TM3 hydrophobic
fMIFL D106 3.33x33 TM3 polar (charge-assisted hydrogen bond)
fMIFL L109 3.36x36 TM3 Van der Waals
fMIFL L109 3.36x36 TM3 hydrophobic
fMIFL F110 3.37x37 TM3 Van der Waals
fMIFL F110 3.37x37 TM3 hydrophobic
fMIFL T177 45.51x51 ECL2 Van der Waals
fMIFL F178 45.52x52 ECL2 hydrophobic
fMIFL F178 45.52x52 ECL2 Van der Waals
fMIFL R201 5.38x39 TM5 polar (charge-assisted hydrogen bond)
fMIFL R205 5.42x43 TM5 polar (charge-assisted hydrogen bond)
fMIFL Y257 6.51x51 TM6 polar (hydrogen bond)
fMIFL Y257 6.51x51 TM6 polar (hydrogen bond)
fMIFL V283 7.35x34 TM7 Van der Waals
fMIFL V283 7.35x34 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 T H ICL1ECL1 G H W P F ECL1ICL2 P V W T Q N H R ICL2ECL2 T T V P G K T G T V A C T F N F S P W T N ECL2ICL3 L I K S ICL3ECL3 I R E L L Q G M ECL3N-term M E T N S S L P T N I S G G T P A V N-termC-term P A S L E R A L T E D S T Q T S D T A T N S T L P S A E V E L Q A K C-term S A G Y L F L D I I T Y L V F A V T F V L G V L G N G L V I W V A G F R M T V T T I S Y L N L A V A D F C F T S T L P F F M V R K A M G G W F L C K F V F T I V D I N L F G S V F L I A L I A L D R C V C V L H T V S L A K K V I I G P W V M A L L L T L P V I I R V D P K E R I N V A V A M L T V R G I I R F I I G F S A P M S I V A V S Y G L I A T K I H K Q G S R P L R V L S F V A A A F F L C W S P Y Q V V A L I A T V R Y K E I G I A V D V T S A L A F F N S C L N P M L Y V F M G Q D L I H F R E R A L
Helix box plot — Download: PNG | SVG G N G L V G L V F T V A F V L Y T I I D 1 L N L A V A D F C F T S T L P F F M V R 2 L A I L F V S G F L N I D V I T F V F K 3 A K K V I I G P W V M A L L L T L P V 4 Y S V A V I S M P A S F G I I F R I I G R 5 S F V A A A F F L C W S P Y Q V V A L I 6 M P N L C S N F F A L A S T V D V A I 7

GPCRdb(A)
GPCRdb(A)
FPR1
TM3
3x29 3.29x29 F102
3x33 3.33x33 D106
3x36 3.36x36 L109
3x37 3.37x37 F110
ECL2
45x51 45.51x51 T177
45x52 45.52x52 F178
TM5
5x39 5.38x39 R201
5x43 5.42x43 R205
TM6
6x51 6.51x51 Y257
TM7
7x34 7.35x34 V283