SST2 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

E

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.3 Å

REFERENCE

PUBLICATION DATE

Oct. 19, 2022

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

Octreotide - Agonist pubchem

PHYSIOLOGICAL LIGANDS

cortistatin-14, SRIF-14, CST-17, SRIF-28



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL2 I 148 - G.H5 K 232 G.H5.12
Van-der-waals ICL2 I 148 - G.H5 K 232 G.H5.12
Polar TM2 T 78 2x39 G.H5 Y 243 G.H5.23
Van-der-waals TM2 T 78 2x39 G.H5 Y 243 G.H5.23
Hydrophobic TM3 R 140 3x50 G.H5 Y 243 G.H5.23
Van-der-waals TM3 R 140 3x50 G.H5 Y 243 G.H5.23
Van-der-waals H8 D 317 8x48 G.H5 N 244 G.H5.24
Hydrophobic ICL2 P 147 - G.H5 L 236 G.H5.16
Hydrophobic ICL2 I 148 - G.H5 I 235 G.H5.15
Hydrophobic TM5 K 234 5x64 G.H5 L 236 G.H5.16
Hydrophobic ICL2 P 147 - G.H5 I 235 G.H5.15
Polar H8 N 318 8x49 G.H5 E 242 G.H5.22
Hydrophobic ICL2 I 148 - G.S3 V 79 G.S3.01
Polar TM3 D 139 3x49 G.H5 Y 243 G.H5.23
Hydrophobic TM6 S 250 6x29 G.H5 V 246 G.H5.26
Van-der-waals TM6 S 250 6x29 G.H5 V 246 G.H5.26
Hydrophobic TM3 A 143 3x53 G.H5 Y 243 G.H5.23
Hydrophobic ICL4 S 316 - G.H5 N 244 G.H5.24
Van-der-waals ICL4 S 316 - G.H5 N 244 G.H5.24
Polar ICL4 L 315 - G.H5 N 244 G.H5.24
Hydrophobic ICL2 I 148 - G.H5 F 228 G.H5.08
Polar ICL3 S 238 - G.H5 D 233 G.H5.13
Polar TM3 A 143 3x53 G.H5 N 239 G.H5.19
Hydrophobic TM3 A 143 3x53 G.H5 N 239 G.H5.19
Van-der-waals TM3 A 143 3x53 G.H5 N 239 G.H5.19
Hydrophobic TM5 V 235 5x65 G.H5 L 240 G.H5.20