M1 receptor - G11

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

Oct. 29, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

iperoxo - Agonist pubchem gtoplig chembl_ligand ,

Nanobody Nb1B4 - Allosteric agonist

PHYSIOLOGICAL LIGANDS

acetylcholine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic ICL2 L 131 34x51 G.H5 V 344 G.H5.11
Hydrophobic ICL2 L 131 34x51 G.H5 K 345 G.H5.12
Van-der-waals ICL2 L 131 34x51 G.H5 K 345 G.H5.12
Hydrophobic TM6 A 323 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 A 323 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM3 V 127 3x54 G.H5 L 349 G.H5.16
Van-der-waals TM3 V 127 3x54 G.H5 L 349 G.H5.16
Polar TM6 K 322 6x32 G.H5 V 359 G.H5.26
Hydrophobic TM6 K 322 6x32 G.H5 V 359 G.H5.26
Van-der-waals TM6 K 322 6x32 G.H5 V 359 G.H5.26
Hydrophobic ICL2 R 134 34x54 G.H5 N 352 G.H5.19
Hydrophobic ICL2 L 131 34x51 G.H5 F 341 G.H5.08
Hydrophobic TM3 R 123 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 123 3x50 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 L 131 34x51 G.H5 I 348 G.H5.15
Van-der-waals ICL2 L 131 34x51 G.H5 I 348 G.H5.15
Polar TM2 N 60 2x39 G.H5 E 355 G.H5.22
Van-der-waals TM2 N 60 2x39 G.H5 E 355 G.H5.22
Polar TM3 S 126 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 S 126 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 S 126 3x53 G.H5 N 352 G.H5.19
Ionic ICL2 R 134 34x54 G.H5 E 355 G.H5.22
Polar ICL2 R 134 34x54 G.H5 E 355 G.H5.22
Van-der-waals ICL2 R 134 34x54 G.H5 E 355 G.H5.22
Polar ICL2 R 134 34x54 G.H5 Y 356 G.H5.23
Van-der-waals ICL2 R 134 34x54 G.H5 Y 356 G.H5.23
Hydrophobic TM6 L 327 6x37 G.H5 L 358 G.H5.25
Van-der-waals TM6 L 327 6x37 G.H5 L 358 G.H5.25
Hydrophobic TM6 T 326 6x36 G.H5 L 358 G.H5.25
Hydrophobic ICL2 P 130 34x50 G.H5 I 348 G.H5.15
Hydrophobic ICL2 P 130 34x50 G.H5 K 345 G.H5.12
Van-der-waals ICL2 P 130 34x50 G.H5 K 345 G.H5.12
Polar TM3 D 122 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 D 122 3x49 G.H5 Y 356 G.H5.23
Polar ICL4 C 381 - G.H5 N 357 G.H5.24
Hydrophobic ICL4 C 381 - G.H5 N 357 G.H5.24
Van-der-waals ICL4 C 381 - G.H5 N 357 G.H5.24
Hydrophobic TM2 N 60 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 N 60 2x39 G.H5 Y 356 G.H5.23
Polar ICL4 N 382 - G.H5 E 355 G.H5.22
Polar TM3 S 126 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM3 S 126 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 S 126 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 123 3x50 G.H5 L 358 G.H5.25
Hydrophobic TM3 V 127 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 V 127 3x54 G.H5 L 353 G.H5.20
Hydrophobic ICL2 P 130 34x50 G.H5 L 349 G.H5.16